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A simple and sensitive TLC method for determination of clopidogrel and its impurity SR 26334 in pharmaceutical products

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Authors
Antić, Dušan
Filipić, Slavica
Agbaba, Danica
Article (Published version)
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Abstract
A simple, conventional TLC method has been established for separation of clopidogrel and its hydrolytic product SR 26334, the main impurity in clopidogrel. Use of aluminium. foil-backed silica gel 60F(254) plates with n-heptane-tetrahydrofuran, 1:1 (v/v), as mobile phase, enabled successful separation of clopidogrel in high excess from the impurity. The separated compounds were detected at 230 nm. Regession coefficients (r >= 0.999), recovery (94.5-107.1%), and limit of quantification (0.047 mg mL(-1)) were evaluated and found to be satisfactory. The method is convenient for quantitative analysis and purity control of clopidogrel both in raw material and in dosage forms.
Source:
Acta Chromatographica, 2007, 18, 199-206
Publisher:
  • Univ Silesia, Inst Chemistry, Katowice

ISSN: 1233-2356

WoS: 000249705200017

Scopus: 2-s2.0-34548263684
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29
20
Handle
https://hdl.handle.net/21.15107/rcub_farfar_970
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/970
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Antić, Dušan
AU  - Filipić, Slavica
AU  - Agbaba, Danica
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/970
AB  - A simple, conventional TLC method has been established for separation of clopidogrel and its hydrolytic product SR 26334, the main impurity in clopidogrel. Use of aluminium. foil-backed silica gel 60F(254) plates with n-heptane-tetrahydrofuran, 1:1 (v/v), as mobile phase, enabled successful separation of clopidogrel in high excess from the impurity. The separated compounds were detected at 230 nm. Regession coefficients (r >= 0.999), recovery (94.5-107.1%), and limit of quantification (0.047 mg mL(-1)) were evaluated and found to be satisfactory. The method is convenient for quantitative analysis and purity control of clopidogrel both in raw material and in dosage forms.
PB  - Univ Silesia, Inst Chemistry, Katowice
T2  - Acta Chromatographica
T1  - A simple and sensitive TLC method for determination of clopidogrel and its impurity SR 26334 in pharmaceutical products
VL  - 18
SP  - 199
EP  - 206
UR  - https://hdl.handle.net/21.15107/rcub_farfar_970
ER  - 
@article{
author = "Antić, Dušan and Filipić, Slavica and Agbaba, Danica",
year = "2007",
abstract = "A simple, conventional TLC method has been established for separation of clopidogrel and its hydrolytic product SR 26334, the main impurity in clopidogrel. Use of aluminium. foil-backed silica gel 60F(254) plates with n-heptane-tetrahydrofuran, 1:1 (v/v), as mobile phase, enabled successful separation of clopidogrel in high excess from the impurity. The separated compounds were detected at 230 nm. Regession coefficients (r >= 0.999), recovery (94.5-107.1%), and limit of quantification (0.047 mg mL(-1)) were evaluated and found to be satisfactory. The method is convenient for quantitative analysis and purity control of clopidogrel both in raw material and in dosage forms.",
publisher = "Univ Silesia, Inst Chemistry, Katowice",
journal = "Acta Chromatographica",
title = "A simple and sensitive TLC method for determination of clopidogrel and its impurity SR 26334 in pharmaceutical products",
volume = "18",
pages = "199-206",
url = "https://hdl.handle.net/21.15107/rcub_farfar_970"
}
Antić, D., Filipić, S.,& Agbaba, D.. (2007). A simple and sensitive TLC method for determination of clopidogrel and its impurity SR 26334 in pharmaceutical products. in Acta Chromatographica
Univ Silesia, Inst Chemistry, Katowice., 18, 199-206.
https://hdl.handle.net/21.15107/rcub_farfar_970
Antić D, Filipić S, Agbaba D. A simple and sensitive TLC method for determination of clopidogrel and its impurity SR 26334 in pharmaceutical products. in Acta Chromatographica. 2007;18:199-206.
https://hdl.handle.net/21.15107/rcub_farfar_970 .
Antić, Dušan, Filipić, Slavica, Agbaba, Danica, "A simple and sensitive TLC method for determination of clopidogrel and its impurity SR 26334 in pharmaceutical products" in Acta Chromatographica, 18 (2007):199-206,
https://hdl.handle.net/21.15107/rcub_farfar_970 .

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