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A chemometrical approach to optimization and validation of an HPLC assay for rizatriptan and its impurities in tablets

Authorized Users Only
2007
Authors
Jocić, B.
Zečević, Mira
Živanović, Lj.
Licanski, A.
Article (Published version)
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Abstract
An isocratic reversed-phase high-performance liquid chromatographic method was developed and validated for the analysis of a novel antimigraine drug, rizatriptan benzoate, in a dosage form along with its two impurities, L-749.019 and L-783.540. The method used a C-18 XTerra (TM) ( 150 x 3.9 mm), 5 mm column. The mobile phase consisted of a mixture of methanol, TEA (1%) and 10 mM KH2PO4 ( 5: 9.5: 85.5 v/v) at a flow rate of 1.2 ml min(-1) ( pH of the water phase was adjusted to 5.5 with 85% orthophosphoric acid). Column temperature was 20 degrees C and the detection was performed at 225 nm. The central composite design technique and the response surface method were used in the robustness test considerations. The method was applied satisfactorily to the analysis of commercial rizatriptan formulation.
Keywords:
rizatriptan benzoate / impurities / dosage form / RP HPLC / method validation
Source:
Analytical Letters, 2007, 40, 12, 2301-2316
Publisher:
  • Taylor & Francis Inc, Philadelphia
Projects:
  • Sinteza, kvantitativni odnosi između strukture/osobina i aktivnosti, fizičko-hemijska karakterizacija i analiza farmakološki aktivnih supstanci (RS-142071)

DOI: 10.1080/00032710701575959

ISSN: 0003-2719

WoS: 000250481100004

Scopus: 2-s2.0-35648972204
[ Google Scholar ]
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/982
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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