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The involvement of peripheral alpha(2)-adrenoceptors in the antihyperalgesic effect of oxcarbazepine in a rat model of inflammatory pain
dc.creator | Tomić, Maja | |
dc.creator | Vučković, Sonja M. | |
dc.creator | Stepanović-Petrović, Radica | |
dc.creator | Ugrešić, Nenad | |
dc.creator | Paranos, Sonja | |
dc.creator | Prostran, Milica | |
dc.creator | Bošković, Bogdan | |
dc.date.accessioned | 2019-09-02T11:11:09Z | |
dc.date.available | 2019-09-02T11:11:09Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0003-2999 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/983 | |
dc.description.abstract | We studied whether peripheral alpha(2)-adrenergic receptors are involved in the antihyperalgesic effects of oxcarbazepine by examining the effects of yohimbine (selective alpha(2)-adrenoceptor antagonist), BRL 44408 (selective alpha(2A)- adrenoceptor antagonist), MK-912 (selective alpha(2C)-adrenoceptor antagonist), and clonidine (alpha(2)-adrenoceptor agonist) on the antihyperalgesic effect of oxcarbazepine in the rat model of inflammatory pain. METHODS: Rats were intraplantarly (i.pl.) injected with the proinflammatory compound concanavalin A (Con A). A paw-pressure test was used to determine: 1) the development of hyperalgesia induced by Con A; 2) the effects of oxcarbazepine (i.pl.) on Con A-induced hyperalgesia; and 3) the effects of i.pl. yohimbine, BRL 44408, MK-912 and clonidine on the oxcarbazepine antihyperalgesia. RESULTS: Both oxcarbazepine (1000-3000 nmol/paw; i.pl.) and clonidine (1.9-7.5 nmol/paw; i.pl.) produced a significant dose-dependent reduction of the paw inflammatory hyperalgesia induced by Con A. Yohimbine (260 and 520 nmol/paw; i.. pl.), BRL44408 (100 and 200 nmol/paw,-i.pl.),and MK-912 (10and 20 nmol/paw;i.pl.) significantly depressed the antihyperalgesic effects of oxcarbazepine (2000 nmol/pav\T,I i.pl.) in a close-dependent mariner. The effects of antagonists were due to local effects since they were not observed after admirdstration into the contralateral hindpaw. Oxcarbazepine and clonidine administered jointly in fixed-dose fractions of the ED50 (1/4, 1/2, and 3/4) caused significant and dose-dependent reduction of hyperalgesia induced by Con A. lsobolographic analysis revealed an additive antihyperalgesic effect. CONCLUSIONS: Our results indicate that the peripheral a,A and a,c adrenoceptors could be involved in the antihyperalgesic effects of oxcarbazepine in a rat model of inflammatory hyperalgesia. (Anesth Analg 2007;105:1474-81) | en |
dc.publisher | Lippincott Williams & Wilkins, Philadelphia | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145001/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145030/RS// | |
dc.rights | restrictedAccess | |
dc.source | Anesthesia and Analgesia | |
dc.title | The involvement of peripheral alpha(2)-adrenoceptors in the antihyperalgesic effect of oxcarbazepine in a rat model of inflammatory pain | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Вучковић, Соња М.; Бошковић, Богдан; Паранос, Соња; Угрешић, Ненад; Степановић-Петровић, Радица; Томић, Маја; Простран, Милица; | |
dc.citation.volume | 105 | |
dc.citation.issue | 5 | |
dc.citation.spage | 1474 | |
dc.citation.epage | 1481 | |
dc.citation.other | 105(5): 1474-1481 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000250317500049 | |
dc.identifier.doi | 10.1213/01.ane.0000287270.35176.3e | |
dc.identifier.pmid | 17959985 | |
dc.identifier.scopus | 2-s2.0-37349011809 | |
dc.type.version | publishedVersion |