Effect of magnesium pretreatment on reduced glutathione levels in tissues of mice exposed to acute and subacute cadmium intoxication: a time course study
Само за регистроване кориснике
2007
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The study was designed to investigate the role of magnesium (Mg) pretreatment on reduced glutathione (GSH) levels in kidney, liver and testis of mice intoxicated with cadmium (Cd). Animals were divided into four groups: I - controls, 11 - Cd group: mice intoxicated with Cd, III - Mg+Cd group: mice given Mg 1 h before Cd, and IV - Mg group: mice given only Mg. In acute time - response studies, the single oral dose of Cd was 20 mg Cd/kg b.w. and 40 mg Mg/kg b.w. GSH levels were determined after 4, 6, 12, 24, and 48 h. In subacute experiments, mice were given 10 mg Cd/kg b.w. orally every day and 20 mg Mg/kg b.w., and GSH content was determined in investigated organs after 1 and 2 weeks. Acute cadmium intoxication significantly decreased the GSH content in liver 4, 6 and 12 h after Cd administration and increased GSH in kidney after 12, 24 and 48 h, but did not cause significant GSH alterations in testis. Mg pretreatment reduced the observed changes of GSH content in kidney and liver. Sub...acute Cd intoxication induced diminished renal GSH levels compared with the controls while the increased GSH levels were observed in liver and testes after 2 weeks Cd treatment. Mg pretreatment was efficient in restoring renal and testis GSH levels towards the control group, but had no effect on hepatic GSH.
Кључне речи:
cd intoxication / Mg pretreatment / Cd-Mg interactions / reduced glutathione / miceИзвор:
Magnesium Research, 2007, 20, 3, 177-186Издавач:
- John Libbey Eurotext Ltd, Montrouge
Институција/група
PharmacyTY - JOUR AU - Đukić-Ćosić, Danijela AU - Ninković, Milica AU - Maličević, Živorad AU - Matović, Vesna AU - Soldatović, Danilo PY - 2007 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/988 AB - The study was designed to investigate the role of magnesium (Mg) pretreatment on reduced glutathione (GSH) levels in kidney, liver and testis of mice intoxicated with cadmium (Cd). Animals were divided into four groups: I - controls, 11 - Cd group: mice intoxicated with Cd, III - Mg+Cd group: mice given Mg 1 h before Cd, and IV - Mg group: mice given only Mg. In acute time - response studies, the single oral dose of Cd was 20 mg Cd/kg b.w. and 40 mg Mg/kg b.w. GSH levels were determined after 4, 6, 12, 24, and 48 h. In subacute experiments, mice were given 10 mg Cd/kg b.w. orally every day and 20 mg Mg/kg b.w., and GSH content was determined in investigated organs after 1 and 2 weeks. Acute cadmium intoxication significantly decreased the GSH content in liver 4, 6 and 12 h after Cd administration and increased GSH in kidney after 12, 24 and 48 h, but did not cause significant GSH alterations in testis. Mg pretreatment reduced the observed changes of GSH content in kidney and liver. Subacute Cd intoxication induced diminished renal GSH levels compared with the controls while the increased GSH levels were observed in liver and testes after 2 weeks Cd treatment. Mg pretreatment was efficient in restoring renal and testis GSH levels towards the control group, but had no effect on hepatic GSH. PB - John Libbey Eurotext Ltd, Montrouge T2 - Magnesium Research T1 - Effect of magnesium pretreatment on reduced glutathione levels in tissues of mice exposed to acute and subacute cadmium intoxication: a time course study VL - 20 IS - 3 SP - 177 EP - 186 UR - https://hdl.handle.net/21.15107/rcub_farfar_988 ER -
@article{ author = "Đukić-Ćosić, Danijela and Ninković, Milica and Maličević, Živorad and Matović, Vesna and Soldatović, Danilo", year = "2007", abstract = "The study was designed to investigate the role of magnesium (Mg) pretreatment on reduced glutathione (GSH) levels in kidney, liver and testis of mice intoxicated with cadmium (Cd). Animals were divided into four groups: I - controls, 11 - Cd group: mice intoxicated with Cd, III - Mg+Cd group: mice given Mg 1 h before Cd, and IV - Mg group: mice given only Mg. In acute time - response studies, the single oral dose of Cd was 20 mg Cd/kg b.w. and 40 mg Mg/kg b.w. GSH levels were determined after 4, 6, 12, 24, and 48 h. In subacute experiments, mice were given 10 mg Cd/kg b.w. orally every day and 20 mg Mg/kg b.w., and GSH content was determined in investigated organs after 1 and 2 weeks. Acute cadmium intoxication significantly decreased the GSH content in liver 4, 6 and 12 h after Cd administration and increased GSH in kidney after 12, 24 and 48 h, but did not cause significant GSH alterations in testis. Mg pretreatment reduced the observed changes of GSH content in kidney and liver. Subacute Cd intoxication induced diminished renal GSH levels compared with the controls while the increased GSH levels were observed in liver and testes after 2 weeks Cd treatment. Mg pretreatment was efficient in restoring renal and testis GSH levels towards the control group, but had no effect on hepatic GSH.", publisher = "John Libbey Eurotext Ltd, Montrouge", journal = "Magnesium Research", title = "Effect of magnesium pretreatment on reduced glutathione levels in tissues of mice exposed to acute and subacute cadmium intoxication: a time course study", volume = "20", number = "3", pages = "177-186", url = "https://hdl.handle.net/21.15107/rcub_farfar_988" }
Đukić-Ćosić, D., Ninković, M., Maličević, Ž., Matović, V.,& Soldatović, D.. (2007). Effect of magnesium pretreatment on reduced glutathione levels in tissues of mice exposed to acute and subacute cadmium intoxication: a time course study. in Magnesium Research John Libbey Eurotext Ltd, Montrouge., 20(3), 177-186. https://hdl.handle.net/21.15107/rcub_farfar_988
Đukić-Ćosić D, Ninković M, Maličević Ž, Matović V, Soldatović D. Effect of magnesium pretreatment on reduced glutathione levels in tissues of mice exposed to acute and subacute cadmium intoxication: a time course study. in Magnesium Research. 2007;20(3):177-186. https://hdl.handle.net/21.15107/rcub_farfar_988 .
Đukić-Ćosić, Danijela, Ninković, Milica, Maličević, Živorad, Matović, Vesna, Soldatović, Danilo, "Effect of magnesium pretreatment on reduced glutathione levels in tissues of mice exposed to acute and subacute cadmium intoxication: a time course study" in Magnesium Research, 20, no. 3 (2007):177-186, https://hdl.handle.net/21.15107/rcub_farfar_988 .