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dc.creatorĐukić-Ćosić, Danijela
dc.creatorNinković, Milica
dc.creatorMaličević, Živorad
dc.creatorMatović, Vesna
dc.creatorSoldatović, Danilo
dc.date.accessioned2019-09-02T11:11:18Z
dc.date.available2019-09-02T11:11:18Z
dc.date.issued2007
dc.identifier.issn0953-1424
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/988
dc.description.abstractThe study was designed to investigate the role of magnesium (Mg) pretreatment on reduced glutathione (GSH) levels in kidney, liver and testis of mice intoxicated with cadmium (Cd). Animals were divided into four groups: I - controls, 11 - Cd group: mice intoxicated with Cd, III - Mg+Cd group: mice given Mg 1 h before Cd, and IV - Mg group: mice given only Mg. In acute time - response studies, the single oral dose of Cd was 20 mg Cd/kg b.w. and 40 mg Mg/kg b.w. GSH levels were determined after 4, 6, 12, 24, and 48 h. In subacute experiments, mice were given 10 mg Cd/kg b.w. orally every day and 20 mg Mg/kg b.w., and GSH content was determined in investigated organs after 1 and 2 weeks. Acute cadmium intoxication significantly decreased the GSH content in liver 4, 6 and 12 h after Cd administration and increased GSH in kidney after 12, 24 and 48 h, but did not cause significant GSH alterations in testis. Mg pretreatment reduced the observed changes of GSH content in kidney and liver. Subacute Cd intoxication induced diminished renal GSH levels compared with the controls while the increased GSH levels were observed in liver and testes after 2 weeks Cd treatment. Mg pretreatment was efficient in restoring renal and testis GSH levels towards the control group, but had no effect on hepatic GSH.en
dc.publisherJohn Libbey Eurotext Ltd, Montrouge
dc.rightsrestrictedAccess
dc.sourceMagnesium Research
dc.subjectcd intoxicationen
dc.subjectMg pretreatmenten
dc.subjectCd-Mg interactionsen
dc.subjectreduced glutathioneen
dc.subjectmiceen
dc.titleEffect of magnesium pretreatment on reduced glutathione levels in tissues of mice exposed to acute and subacute cadmium intoxication: a time course studyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНинковић, Милица; Матовић, Весна; Солдатовић, Данило; Маличевић, Живорад; Ђукић-Ћосић, Данијела;
dc.citation.volume20
dc.citation.issue3
dc.citation.spage177
dc.citation.epage186
dc.citation.other20(3): 177-186
dc.citation.rankM23
dc.identifier.wos000250149300003
dc.identifier.pmid17972460
dc.identifier.scopus2-s2.0-35248896262
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_farfar_988
dc.type.versionpublishedVersion


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Приказ основних података о документу