Show simple item record

dc.creatorPeruničić-Peković, Gordana
dc.creatorRasić, Zorica
dc.creatorPlješa, Steva
dc.creatorŠobajić, Slađana
dc.creatorĐuričić, Ivana
dc.creatorMaletić, Radojka
dc.creatorRistić-Medić, Danijela K.
dc.date.accessioned2019-09-02T11:11:20Z
dc.date.available2019-09-02T11:11:20Z
dc.date.issued2007
dc.identifier.issn1320-5358
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/990
dc.description.abstractAims: Nutrition as an aetiological factor participates a great deal in premature atherosclerosis in haemodialysis (HD) patients. The basic mechanisms of end-stage renal disease and premature atherosclerosis are connected with changes in cell functions at the membrane level. We investigated the red cell membrane fatty acids and the effects of fish oil supplements on nutritional status and inflammatory markers in HD patients. Methods: We examined 42 HD patients (mean age 55 +/- 8 years). The control group consisted of 16 healthy subjects of similar age and sex to the tested group. HD patients were administered supplements with 2.4 g of n-3 polyunsaturated fatty acids per day for 2 months. Before and after supplementation, we examined plasma lipids, cell membrane erythrocyte phospholipids content, serum albumin, haemoglobin, interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-alpha). Results: Baseline values in the tested group confirmed the presence of essential fatty acids deficiency. A statistically significant negative correlation between TNF-alpha and eicosapentaenoic acid (EPA) (r=-0.497; P lt 0.05) and IL-6 and EPA (r=-468; P=0.03) was found in HD patients before supplementation. There was a significant increase in docosahexaenoic acids, high density lipoprotein cholesterol, plasma albumin, haemoglobin levels in HD patients after supplementation (P=0.0001). There was a significant increase in EPA (P=0.01) after treatment, and there was a significant decrease in inflammatory markers (IL-6 and TNF-alpha, P=0.0001) after supplementation in the tested group. Conclusion: A dietary regime with fish oil could be used in dialysis patients to slow down the development of atherosclerosis and improve nutritional parameters.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145071/RS//
dc.rightsrestrictedAccess
dc.sourceNephrology
dc.subjectESRDen
dc.subjectinflammationen
dc.subjectmalnutritionen
dc.subjectphospholipiden
dc.subjectPUFAen
dc.subjectred cellen
dc.titleEffect of n-3 fatty acids on nutritional status and inflammatory markers in haemodialysis patientsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЂуричић, Ивана; Пљеша, Стева; Перуничић-Пековић, Гордана; Расић, Зорица; Ристић-Медић, Данијела К.; Малетић, Радојка; Шобајић, Слађана;
dc.citation.volume12
dc.citation.issue4
dc.citation.spage331
dc.citation.epage336
dc.citation.other12(4): 331-336
dc.citation.rankM23
dc.identifier.wos000248372800003
dc.identifier.doi10.1111/j.1440-1797.2007.00777.x
dc.identifier.pmid17635746
dc.identifier.scopus2-s2.0-34447545528
dc.identifier.rcubconv_1877
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record