This work investigates the anti- inflammatory activity of methanol extracts of four endemic Stachys ( Labiatae) taxa from the Balkans: S. beckeana Dorfler & Hayek, S. anisochila Vis. et Pancic, S. plumosa Griseb., and S. alpina L. subsp. dinarica Murb. As a model of acute inflammation, carrageenan- induced paw edema in rats was used. Extracts, applied at doses of 50, 100, and 200 mg/ kg p. o., exhibited dose- dependent activity. S. beckeana and S. anisochila extracts were the most active ones ( ED50 154.52 and 162.24 mg/ kg, respectively), with the activity comparable with indomethacin at doses of 2 and 4 mg/ kg. S. plumosa extract has shown less- pronounced anti- inflammatory effect ( ED50 220.81 mg= kg). Extract of S. alpina subsp. dinarica had the lowest efficiency, attenuating inflammation less than 50%.
Keywords:
anti-inflammatory activity / dinarica / S. alpina subsp. / S. beckeana / S. plumosa / Stachys anisochila
TY - JOUR
AU - Kukić, Jelena
AU - Dobrić, Silva
AU - Petrović, Silvana
PY - 2007
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/991
AB - This work investigates the anti- inflammatory activity of methanol extracts of four endemic Stachys ( Labiatae) taxa from the Balkans: S. beckeana Dorfler & Hayek, S. anisochila Vis. et Pancic, S. plumosa Griseb., and S. alpina L. subsp. dinarica Murb. As a model of acute inflammation, carrageenan- induced paw edema in rats was used. Extracts, applied at doses of 50, 100, and 200 mg/ kg p. o., exhibited dose- dependent activity. S. beckeana and S. anisochila extracts were the most active ones ( ED50 154.52 and 162.24 mg/ kg, respectively), with the activity comparable with indomethacin at doses of 2 and 4 mg/ kg. S. plumosa extract has shown less- pronounced anti- inflammatory effect ( ED50 220.81 mg= kg). Extract of S. alpina subsp. dinarica had the lowest efficiency, attenuating inflammation less than 50%.
PB - Taylor & Francis Ltd, Abingdon
T2 - Pharmaceutical Biology
T1 - Influence of some Stachys taxa on carrageenan-induced paw edema in rats
VL - 45
IS - 7
SP - 560
EP - 563
DO - 10.1080/13880200701498937
ER -
@article{
author = "Kukić, Jelena and Dobrić, Silva and Petrović, Silvana",
year = "2007",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/991",
abstract = "This work investigates the anti- inflammatory activity of methanol extracts of four endemic Stachys ( Labiatae) taxa from the Balkans: S. beckeana Dorfler & Hayek, S. anisochila Vis. et Pancic, S. plumosa Griseb., and S. alpina L. subsp. dinarica Murb. As a model of acute inflammation, carrageenan- induced paw edema in rats was used. Extracts, applied at doses of 50, 100, and 200 mg/ kg p. o., exhibited dose- dependent activity. S. beckeana and S. anisochila extracts were the most active ones ( ED50 154.52 and 162.24 mg/ kg, respectively), with the activity comparable with indomethacin at doses of 2 and 4 mg/ kg. S. plumosa extract has shown less- pronounced anti- inflammatory effect ( ED50 220.81 mg= kg). Extract of S. alpina subsp. dinarica had the lowest efficiency, attenuating inflammation less than 50%.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Pharmaceutical Biology",
title = "Influence of some Stachys taxa on carrageenan-induced paw edema in rats",
volume = "45",
number = "7",
pages = "560-563",
doi = "10.1080/13880200701498937"
}
Kukić J, Dobrić S, Petrović S. Influence of some Stachys taxa on carrageenan-induced paw edema in rats. Pharmaceutical Biology. 2007;45(7):560-563
Kukić, J., Dobrić, S.,& Petrović, S. (2007). Influence of some Stachys taxa on carrageenan-induced paw edema in rats.
Pharmaceutical BiologyTaylor & Francis Ltd, Abingdon., 45(7), 560-563.
https://doi.org/10.1080/13880200701498937
Kukić Jelena, Dobrić Silva, Petrović Silvana, "Influence of some Stachys taxa on carrageenan-induced paw edema in rats" 45, no. 7 (2007):560-563,
https://doi.org/10.1080/13880200701498937 .
