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dc.creatorTubić, Biljana
dc.creatorIvković, Branka
dc.creatorZečević, Mira
dc.creatorVladimirov, S.
dc.date.accessioned2019-09-02T11:11:23Z
dc.date.available2019-09-02T11:11:23Z
dc.date.issued2007
dc.identifier.issn1318-0207
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/992
dc.description.abstractA simple, rapid and reproducible reversed-phase high-performance liquid chromatography method for the analysis of nimesulide and its impurities both in the bulk drug and pharmaceutical formulations is reported. The method is suitable for monitoring the stability of nimesulide. The presence of nimesulide impurities C (2- phenoxyaniline) and D (2- phenoxy4- nitroaniline) was observed. The best separation was achieved using an Agilent Zorbax Extend C-18 column ( 150 x 4.6 mm, particle size 5 mu m) at 40 C and flow rate of 1.0 mLmin(-1). The analytes were monitored at 230 nm. The mobile phase consisted of acetonitrile - triethylamine (TEA) - water (45:0.5:54.5 v/v/v), adjusted to pH 5.2 with formic acid. Under these conditions the retention times were of 7.11, 7.98 and 8.66 min for nimesulide, D and C, respectively. The resolution of nimesulide and impurity D was 3.20 and that of impurity D and impurity C 2.40, indicating that the compounds were well separated. Evaluation of linearity, accuracy, precision, selectivity, sensitivity and robustness of the method produced satisfactory results. The developed method was successfully applied to assay nimesulide in different solid pharmaceutical formulations.en
dc.publisherSlovensko Kemijsko Drustvo, Ljubljana
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142072/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceActa Chimica Slovenica
dc.subjectnimesulideen
dc.subjectimpuritiesen
dc.subjectdegradation productsen
dc.subjectRP-HPLCen
dc.titleSimulataneous determination of nimesulide and its impurities in pharmaceutical formulations by reversed-phase high-performance liquid chromatographyen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractИвковић, Бранка; Зечевић, Мира; Владимиров, С.; Тубић, Биљана;
dc.citation.volume54
dc.citation.issue3
dc.citation.spage583
dc.citation.epage590
dc.citation.other54(3): 583-590
dc.citation.rankM22
dc.identifier.wos000249793300021
dc.identifier.scopus2-s2.0-35548959506
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs/bitstream/id/7445/Simulataneous_determination_of_pub_2007.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_farfar_992
dc.type.versionpublishedVersion


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