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Monitoring of the photochemical stability of carvedilol and its degradation products by the RP-HPLC method
Praćenje fotohemijske stabilnosti karvedilola i njegovih degradacionih proizvoda RP-HPLC metodom
dc.creator | Stojanović, Jelena | |
dc.creator | Vladimirov, Sote | |
dc.creator | Marinković, Valentina | |
dc.creator | Veličković, Dragan | |
dc.creator | Sibinović, Predrag | |
dc.date.accessioned | 2019-09-02T11:11:36Z | |
dc.date.available | 2019-09-02T11:11:36Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0352-5139 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/999 | |
dc.description.abstract | A sensitive, selective, precise and stability-indicating, new high-performance liquid chromatographic method for the analysis of carvedilol both as a bulk drug and in formulations was developed and validated. As the method could effectively separate the drug from its degradation products, it can be employed as a stability-indicating one. The method was validated for linearity, selectivity, precision, robustness, LOD, LOQ and accuracy. The chromatographic separation was achieved on a Chromolit RP8e, 100x4.6 mm, analytical column. The mobile phase consisted of a mixture of acetonitrile and water (45:55, V/V) (pH 2.5), pH adjusted with formic acid. The absorbance was monitored with a UV detector at 280 nm and the temperature of the analyses was 40°C. The flow rate was 0.5 mL/min. The linearity (r≥ 0.999), reproducibility (0.68-1.27 %) and recovery (99.71-101.58) were found to be satisfactory. This method enables the simultaneous determination of carvedilol and its degradation products, as well as stability. | en |
dc.description.abstract | Karvedilol je neselektivni beta blokator sa vazodilatatornim i antioksidativnim svojstvima. Primenjuje se u terapiji hipertenzije, angine pektoris i kongestivne srčane insuficijencije. Razvijena je i validirana nova HPLC metoda za istovremenu kvalitativnu i kvantitativnu analizu karvedilola i njegovih nečistoća kao i za praćenje fotohemijske stabilnosti ovog jedinjenja. Metoda je validirana na linearnost, selektivnost, preciznost, robustnost, LOD, LOQ i tačnost. Optimalni uslovi postignuti su korišćenjem hromatografske kolone Chromolit RP 8e, 100x4,6 mm. Mobilnu fazu predstavlja smeša acetonitrila i vode u odnosu 45:55 pri pH 2,5. Analiza se odvija na temperaturi od 40°C pri protoku 0,5 ml/min a talasna dužina UV detektora iznosi 280 nm. Linearnost (r≥0,999), reproduktivnost (0,68-1,27%), i rikaveri (99,71-101,58) pokazuju zadovoljavajuće vrednosti. Hromatografska analiza je pokazala da se kao glavni proizvod degradacije karvedilola javlja 4-hidroksikarbazol, dok nečistoća C nije prisutna pod ovim uslovima. Predložena RP-HPLC metoda je brza, precizna, tačna, osetljiva, pouzdana i primenljiva za kvalitativnu i kvantitativnu analizu KarvileksR tablete, kao i za praćenje stabilnosti ovog leka. | sr |
dc.publisher | Srpsko hemijsko društvo, Beograd | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Journal of the Serbian Chemical Society | |
dc.subject | carvedilol | en |
dc.subject | 4-hydroxycarbazole | en |
dc.subject | RP-HPLC | en |
dc.subject | stability | en |
dc.title | Monitoring of the photochemical stability of carvedilol and its degradation products by the RP-HPLC method | en |
dc.title | Praćenje fotohemijske stabilnosti karvedilola i njegovih degradacionih proizvoda RP-HPLC metodom | sr |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Сибиновић, Предраг; Величковић, Драган; Маринковић, Валентина; Стојановић, Јелена; Владимиров, Соте; Праћење фотохемијске стабилности карведилола и његових деградационих производа РП-ХПЛЦ методом; Праћење фотохемијске стабилности карведилола и његових деградационих производа РП-ХПЛЦ методом; | |
dc.citation.volume | 72 | |
dc.citation.issue | 1 | |
dc.citation.spage | 37 | |
dc.citation.epage | 44 | |
dc.citation.other | 72(1): 37-44 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000244433700005 | |
dc.identifier.doi | 10.2298/JSC0701037S | |
dc.identifier.scopus | 2-s2.0-33846967127 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/2320/997.pdf | |
dc.type.version | publishedVersion |