The mechanism of histamine-induced relaxation in the isolated rat common carotid artery was analysed. Histamine (3 × 10-7 -10-4 mol/1) caused a concentration-dependent relaxation of the artery. In-domethacin, a cyclo-oxygenase inhibitor, and diethylcarbamazine, a lipoxygenase inhibitor, did not affect the relaxant response of the artery to histamine. After removal of the vascular endothelium the histamine-induced relaxation was strongly reduced. Moreover, hemoglobin and methylene blue, inhibitors of endothelium-derived relaxing factor (EDRF), prevented or reversed the relaxant effect of histamine. These findings confirm that the histamine-induced relaxation is to a greater extent endothelium dependent. It is concluded that the endothelium-dependent component in the relaxant response of the rat common carotid artery to histamine results from the release of EDRF.
Source:
Archives of Physiology and Biochemistry, 1992, 100, 1, 101-103
TY - JOUR
AU - Krstić, M.K
AU - Stepanović-Petrović, Radica
AU - Vučković, Sonja M.
AU - Krstić, S.K
PY - 1992
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/99
AB - The mechanism of histamine-induced relaxation in the isolated rat common carotid artery was analysed. Histamine (3 × 10-7 -10-4 mol/1) caused a concentration-dependent relaxation of the artery. In-domethacin, a cyclo-oxygenase inhibitor, and diethylcarbamazine, a lipoxygenase inhibitor, did not affect the relaxant response of the artery to histamine. After removal of the vascular endothelium the histamine-induced relaxation was strongly reduced. Moreover, hemoglobin and methylene blue, inhibitors of endothelium-derived relaxing factor (EDRF), prevented or reversed the relaxant effect of histamine. These findings confirm that the histamine-induced relaxation is to a greater extent endothelium dependent. It is concluded that the endothelium-dependent component in the relaxant response of the rat common carotid artery to histamine results from the release of EDRF.
PB - Informa Healthcare
T2 - Archives of Physiology and Biochemistry
T1 - Evidence that endothelium-dependent relaxation to histamine in the rat common carotid artery is mediated by EDRF
VL - 100
IS - 1
SP - 101
EP - 103
DO - 10.3109/13813459209035267
ER -
@article{
author = "Krstić, M.K and Stepanović-Petrović, Radica and Vučković, Sonja M. and Krstić, S.K",
year = "1992",
abstract = "The mechanism of histamine-induced relaxation in the isolated rat common carotid artery was analysed. Histamine (3 × 10-7 -10-4 mol/1) caused a concentration-dependent relaxation of the artery. In-domethacin, a cyclo-oxygenase inhibitor, and diethylcarbamazine, a lipoxygenase inhibitor, did not affect the relaxant response of the artery to histamine. After removal of the vascular endothelium the histamine-induced relaxation was strongly reduced. Moreover, hemoglobin and methylene blue, inhibitors of endothelium-derived relaxing factor (EDRF), prevented or reversed the relaxant effect of histamine. These findings confirm that the histamine-induced relaxation is to a greater extent endothelium dependent. It is concluded that the endothelium-dependent component in the relaxant response of the rat common carotid artery to histamine results from the release of EDRF.",
publisher = "Informa Healthcare",
journal = "Archives of Physiology and Biochemistry",
title = "Evidence that endothelium-dependent relaxation to histamine in the rat common carotid artery is mediated by EDRF",
volume = "100",
number = "1",
pages = "101-103",
doi = "10.3109/13813459209035267"
}
Krstić, M.K, Stepanović-Petrović, R., Vučković, S. M.,& Krstić, S.K. (1992). Evidence that endothelium-dependent relaxation to histamine in the rat common carotid artery is mediated by EDRF. in Archives of Physiology and Biochemistry
Informa Healthcare., 100(1), 101-103.
https://doi.org/10.3109/13813459209035267
Krstić M, Stepanović-Petrović R, Vučković SM, Krstić S. Evidence that endothelium-dependent relaxation to histamine in the rat common carotid artery is mediated by EDRF. in Archives of Physiology and Biochemistry. 1992;100(1):101-103.
doi:10.3109/13813459209035267 .
Krstić, M.K, Stepanović-Petrović, Radica, Vučković, Sonja M., Krstić, S.K, "Evidence that endothelium-dependent relaxation to histamine in the rat common carotid artery is mediated by EDRF" in Archives of Physiology and Biochemistry, 100, no. 1 (1992):101-103,
https://doi.org/10.3109/13813459209035267 . .
