Приказ основних података о документу
Evidence that endothelium-dependent relaxation to histamine in the rat common carotid artery is mediated by EDRF
dc.creator | Krstić, M.K | |
dc.creator | Stepanović-Petrović, Radica | |
dc.creator | Vučković, Sonja M. | |
dc.creator | Krstić, S.K | |
dc.date.accessioned | 2019-09-02T10:48:27Z | |
dc.date.available | 2019-09-02T10:48:27Z | |
dc.date.issued | 1992 | |
dc.identifier.issn | 1381-3455 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/99 | |
dc.description.abstract | The mechanism of histamine-induced relaxation in the isolated rat common carotid artery was analysed. Histamine (3 × 10-7 -10-4 mol/1) caused a concentration-dependent relaxation of the artery. In-domethacin, a cyclo-oxygenase inhibitor, and diethylcarbamazine, a lipoxygenase inhibitor, did not affect the relaxant response of the artery to histamine. After removal of the vascular endothelium the histamine-induced relaxation was strongly reduced. Moreover, hemoglobin and methylene blue, inhibitors of endothelium-derived relaxing factor (EDRF), prevented or reversed the relaxant effect of histamine. These findings confirm that the histamine-induced relaxation is to a greater extent endothelium dependent. It is concluded that the endothelium-dependent component in the relaxant response of the rat common carotid artery to histamine results from the release of EDRF. | en |
dc.publisher | Informa Healthcare | |
dc.rights | restrictedAccess | |
dc.source | Archives of Physiology and Biochemistry | |
dc.title | Evidence that endothelium-dependent relaxation to histamine in the rat common carotid artery is mediated by EDRF | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Крстић, М.К; Степановић-Петровић, Радица; Крстић, С.К; Вучковић, Соња М.; | |
dc.citation.volume | 100 | |
dc.citation.issue | 1 | |
dc.citation.spage | 101 | |
dc.citation.epage | 103 | |
dc.citation.other | 100(1): 101-103 | |
dc.description.other | Scientific Fund of Serbia (Grant No. 231). | |
dc.identifier.doi | 10.3109/13813459209035267 | |
dc.identifier.scopus | 2-s2.0-0026493478 | |
dc.type.version | publishedVersion |