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Determination of carvedilol and its impurities in pharmaceuticals
(Vieweg, Wiesbaden, 2005)
A reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed for separation of carvedilol and its impurities from Karvileks tablets. The best separation was achieved on a 100 mm x 4.6 mm, 5 ...
Chemometrical approach in fosinopril-sodium and its degradation product fosinoprilat analysis
(Springer Heidelberg, Heidelberg, 2004)
In this paper the experimental design has been applied to define the optimum chromatographic conditions for the separation of Fosinopril sodium and its degradation product, fosinoprilat. Fosinopril is a prodrug and after ...
Stability testing of cefuroxime in tablets by micellar liquid chromatography
(Springer Heidelberg, Heidelberg, 2004)
Cefuroxime is a broad-spectrum second-generation bactericidal cephalosporin antibiotic active against beta-lactamose-producing strains. Anti-cefuroxime, the geometric isomer of cefuroxime, might be present in cefuroxime ...
Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC
(Springer Heidelberg, Heidelberg, 2005)
A simple, precise and sensitive reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed for the quantitation of bifonazole, an imidazole antifungal, simultaneously with benzyl alcohol, ...
Chromatographic behavior of fosinopril sodium and fosinoprilat using neural networks
(Springer Heidelberg, Heidelberg, 2008)
In this paper, the chromatographic characterization of fosinopril sodium and fosinoprilat is presented. The first stept was pK(a) determination for the active substance and its degradation product using RP-LC. It was ...
Validation of an HPLC method for the determination of valdecoxib and its degradation product: a mixture of alpha- and beta-n-lactosyl sulfonamide anomers
(Vieweg, Wiesbaden, 2007)
An HPLC method has been developed for the separation of valdecoxib and a degradation product consisting of alpha and beta-N-lactosyl sulfonamide, i.e. alpha and beta anomers (SC-77852). Best results were achieved with a ...
Monitoring of Simvastatin impurities by HPLC with microemulsion eluents
(Springer Heidelberg, Heidelberg, 2006)
The use of microemulsions as eluents in HPLC has shown excellent potential. We have developed a novel approach for the analysis of Simvastatin and its six impurities, applying microemulsions as mobile phase. The method was ...
Application of Multicriteria Methodology in the Development of Improved RP-LC-DAD for Determination of Rizatriptan and Its Degradation Products
(Vieweg, Wiesbaden, 2008)
The aim of this study was to establish an improved isocratic RP-LC-DAD method for separation and determination of rizatriptan benzoate and its two degradation products, L-749.019 and L-783.540 in tablets. Since the ...
Chromatographic determination of dissociation constants of pramipexole and its impurities
(Vieweg, Wiesbaden, 2007)
The main goal in this investigation was monocratic HPLC determination of dissociation constant values (pK(a)) of pramipexole and its impurities, BI-II 546 CL, BI-II 751 xx and 2-aminobenzothiazole. The chromatographic ...