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Analysis of fluidized bed granulation process using conventional and novel modeling techniques
(Elsevier Science BV, Amsterdam, 2011)
Various modeling techniques have been applied to analyze fluidized-bed granulation process. Influence of various input parameters (product, inlet and outlet air temperature, consumption of liquid-binder, granulation ...
Coupled in silico platform: Computational fluid dynamics (CFD) and physiologically-based pharmacokinetic (PBPK) modelling
(Elsevier Science BV, Amsterdam, 2018)
One of the critical components of the respiratory drug delivery is the manner in which the inhaled aerosol is deposited in respiratory tract compartments. Depending on formulation properties, device characteristics and ...
Population exposure-response model of 131I in patients with benign thyroid disease
(Elsevier B.V., 2021)
Purpose: The study aimed to explore the relationship of different exposure measures with 131I therapy response in patients with benign thyroid disease, estimate the variability in the response, investigate possible covariates, ...
The influence of drug-drug interaction and patients' characteristics on valproic acid's clearance in adults with epilepsy using nonlinear mixed effects modeling
(Elsevier Science BV, Amsterdam, 2009)
Monitoring valproic acid (VPA) concentrations is especially challenging due to its highly variable pharmacokinetics (PK) and complex interactions with other antiepileptic drugs. We used sparse routine therapeutic drug ...
Sucrose esters as biocompatible surfactants for penetration enhancement: An insight into the mechanism of penetration enhancement studied using stratum corneum model lipids and Langmuir monolayers
(Elsevier Science BV, Amsterdam, 2017)
Up to now, the molecular mechanism of the penetration enhancing effect of sucrose esters (SEs) on stratum corneum (SC) has not been explained in details. In this study, variety of surface sensitive techniques, including ...
P43 Improvement of color stability in pork meat depending on dietary selenium supplementation
(European Journal of Pharmaceutical Sciences, 1994)
The role of therapeutic drug monitoring in optimazing pharmacotherapy of selected antiepileptics
(Elsevier Science BV, Amsterdam, 2009)
Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products
(Elsevier Science BV, Amsterdam, 2018)
In vitro dissolution testing is routinely used in the development of pharmaceutical products. Whilst the dissolution testing methods are well established and standardized for oral dosage forms, i.e. tablets and capsules, ...
In vitro prediction of gastrointestinal absorption of novel beta-hydroxy-beta-arylalkanoic acids using PAMPA technique
(Elsevier Science BV, Amsterdam, 2017)
Prediction of gastrointestinal absorption of thirteen newly synthesized beta-hydroxy-beta-arylalkanoic acids (HAA) and ibuprofen was performed using PAMPA test The highest values of PAMPA parameters (%Tand P-app) were ...
Prediction of blood-brain barrier permeation of alpha-adrenergic and imidazoline receptor ligands using PAMPA technique and quantitative-structure permeability relationship analysis
(Elsevier Science BV, Amsterdam, 2015)
Imidazoline receptor ligands are a numerous family of biologically active compounds known to produce central hypotensive effect by interaction with both alpha(2)-adrenoreceptors (alpha(2)-AR) and imidazoline receptors ...