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Regio- and Stereoselective, Intramolecular [2+2] Cycloaddition of Allenes, Promoted by Visible Light Photocatalysis
(John Wiley and Sons Inc, 2023)
Enallenylamides have been utilized for the synthesis of heterobicycle[4.2.0]octane derivatives via Ir/hν promoted [2+2] cycloaddition reaction. The reaction specifically targets the distal double bond of the allene moiety, ...
In vivo and in silico approach in revealing the influence of lead (Pb) on thyroid gland function
(Elsevier, 2023)
The purpose of this study was to examine the impact of low doses of lead (Pb) on levels of thyroid hormones (T3, T4, FT3, and FT4) and thyroid-related antibodies (anti-Tg and anti-TPO) in the rat model, as well as genes ...
The antidepressant drugs vortioxetine and duloxetine differentially and sex-dependently affect animal well-being, cognitive performance, cardiac redox status and histology in a model of osteoarthritis
(Elsevier Masson, 2023)
Osteoarthritis represents a leading cause of disability with limited treatment options. Furthermore, it is frequently accompanied by cardiovascular and cognitive disorders, which can be exacerbated by osteoarthritis or ...
Pros and Cons of Long-Chain Omega-3 Polyunsaturated Fatty Acids in Cardiovascular Health
(Annual Reviews Inc, 2023)
The long-chain omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are found in seafood, supplements, and concentrated pharmaceutical preparations. Prospective cohort studies demonstrate an ...
Results of the first survey of the EFLM Task Force Preparation of Labs for Emergencies (TF-PLE)
(De Gruyter Open Ltd, 2023)
Digital transformation towards the clinical laboratory of the future. Perspectives for the next decade
(De Gruyter Open Ltd, 2023)
The transformation of clinical laboratories towards digitalization requires processes that improve digital maturity. This requires establishing connectivity, end-to-end workflow, and advanced analytical technologies and ...
Adrenoceptors as potential target for add-on immunomodulatory therapy in multiple sclerosis
(Elsevier Inc., 2023)
This review summarizes recent findings related to the role of the sympathetic nervous system (SNS) in pathogenesis of multiple sclerosis (MS) and its commonly used experimental model – experimental autoimmune encephalomyelitis ...
Three kinds of W-potentials in nonlinear biophysics of microtubules
(Elsevier, 2023)
In the present article we investigate the nonlinear dynamics of microtubules, the basic components of the eukaryotic cytoskeleton, relying on the known general model. We introduce the W-potential energy, describing a crucial ...
Goat milk proteins enriched with Agaricus blazei Murrill ss. Heinem extracts: Electrophoretic, FTIR, DLS and microstructure characterization
(Elsevier Ltd, 2023)
This study aimed to characterize mixtures of goat milk proteins and Agaricus blazei Murrill (ABM) extracts (aqueous, AE and polysaccharides, PE). The mixtures showed stable particles with ζ-potential more negative than ...
Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study
(Academic Press Inc., 2023)
Toxic metals (cadmium (Cd), lead (Pb), mercury (Hg) and arsenic (As)) and plastificators (bis (2 – ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP)) and bisphenol A (BPA)) have been suggested to aid in colorectal ...