The antinociceptive effects of anticonvulsants in a mouse visceral pain model
Само за регистроване кориснике
2008
Аутори
Stepanović-Petrović, RadicaTomić, Maja
Vučković, Sonja M.
Paranos, Sonja
Ugrešić, Nenad
Prostran, Milica
Milovanović, Slobocian
Bošković, Bogdan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
BACKGROUND: There is evidence supporting the antinociceptive effects of carbamazepine, oxcarbazepine, gabapentin, and topiramate in various models of neuropathic pain as well as inflammatory somatic pain. Data are lacking on the antinociceptive potential of these drugs against visceral pain. In this study, we examined and compared the effects of carbamazepine, oxcarbazepine, gabapentin, and topiramate in the writhing test as a visceral pain model in the mouse. In addition, the influence of these anticonvulsants on motor performance was examined to compare the tolerability of these anticonvulsants when used against acute visceral pain. METHODS: The antinociceptive effects of these anticonvulsants were examined in the acetic acid writhing test in mice. The side effect propensity of these drugs was examined using the rotarod test. RESULTS: Carbamazepine (25-60 mg/kg; p.o.), oxcarbazepine (10-40 mg/kg; p.o.), gabapentin (10-70 mg/kg; p.o.), and topiramate (5-30 mg/kg; p.o.) caused a signif...icant dose-dependent reduction the number of writhes in the writhing test. In the rotarod test, carbamazepine (60-140 mg/kg; p.o.) and oxcarbazepine (120-450 mg/kg; p.o.) significantly reduced the time spent on the rotarod in a dose- and time-dependent manner. Gabapentin (1000-2000 mg/kg; p.o.) and topiramate (400-1500 mg/kg; p.o.) did not produce significant impairment of motor performance at the highest doses used. The therapeutic index (motor impairing dose TD50)/writhing ED50) values were topiramate (>148.5) > gabapentin (>60.2) > oxcarbazepine (15.2) > carbamazepine (2.3). CONCLUSIONS: These results indicate that oxcarbazepine, gabapentin, and topiramate are effective in the writhing model in mice, in a dose range, which is not related to motor impairment; topiramate is the most potent and the most tolerable drug.
Извор:
Anesthesia and Analgesia, 2008, 106, 6, 1897-1903Издавач:
- Lippincott Williams & Wilkins, Philadelphia
Финансирање / пројекти:
- Експериментална и клиничко-фармаколошка истраживања механизма дејства и интеракција лекова у нервном и кардиоваскуларном систему (RS-145001)
- Испитивање механизма дејства, интеракција и токсичних ефеката аналгетика као и вазоактивних супстанци (RS-145030)
DOI: 10.1213/ane.0b013618172b993
ISSN: 0003-2999
PubMed: 18499629
WoS: 000256075200045
Scopus: 2-s2.0-44649102665
Институција/група
PharmacyTY - JOUR AU - Stepanović-Petrović, Radica AU - Tomić, Maja AU - Vučković, Sonja M. AU - Paranos, Sonja AU - Ugrešić, Nenad AU - Prostran, Milica AU - Milovanović, Slobocian AU - Bošković, Bogdan PY - 2008 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1067 AB - BACKGROUND: There is evidence supporting the antinociceptive effects of carbamazepine, oxcarbazepine, gabapentin, and topiramate in various models of neuropathic pain as well as inflammatory somatic pain. Data are lacking on the antinociceptive potential of these drugs against visceral pain. In this study, we examined and compared the effects of carbamazepine, oxcarbazepine, gabapentin, and topiramate in the writhing test as a visceral pain model in the mouse. In addition, the influence of these anticonvulsants on motor performance was examined to compare the tolerability of these anticonvulsants when used against acute visceral pain. METHODS: The antinociceptive effects of these anticonvulsants were examined in the acetic acid writhing test in mice. The side effect propensity of these drugs was examined using the rotarod test. RESULTS: Carbamazepine (25-60 mg/kg; p.o.), oxcarbazepine (10-40 mg/kg; p.o.), gabapentin (10-70 mg/kg; p.o.), and topiramate (5-30 mg/kg; p.o.) caused a significant dose-dependent reduction the number of writhes in the writhing test. In the rotarod test, carbamazepine (60-140 mg/kg; p.o.) and oxcarbazepine (120-450 mg/kg; p.o.) significantly reduced the time spent on the rotarod in a dose- and time-dependent manner. Gabapentin (1000-2000 mg/kg; p.o.) and topiramate (400-1500 mg/kg; p.o.) did not produce significant impairment of motor performance at the highest doses used. The therapeutic index (motor impairing dose TD50)/writhing ED50) values were topiramate (>148.5) > gabapentin (>60.2) > oxcarbazepine (15.2) > carbamazepine (2.3). CONCLUSIONS: These results indicate that oxcarbazepine, gabapentin, and topiramate are effective in the writhing model in mice, in a dose range, which is not related to motor impairment; topiramate is the most potent and the most tolerable drug. PB - Lippincott Williams & Wilkins, Philadelphia T2 - Anesthesia and Analgesia T1 - The antinociceptive effects of anticonvulsants in a mouse visceral pain model VL - 106 IS - 6 SP - 1897 EP - 1903 DO - 10.1213/ane.0b013618172b993 ER -
@article{ author = "Stepanović-Petrović, Radica and Tomić, Maja and Vučković, Sonja M. and Paranos, Sonja and Ugrešić, Nenad and Prostran, Milica and Milovanović, Slobocian and Bošković, Bogdan", year = "2008", abstract = "BACKGROUND: There is evidence supporting the antinociceptive effects of carbamazepine, oxcarbazepine, gabapentin, and topiramate in various models of neuropathic pain as well as inflammatory somatic pain. Data are lacking on the antinociceptive potential of these drugs against visceral pain. In this study, we examined and compared the effects of carbamazepine, oxcarbazepine, gabapentin, and topiramate in the writhing test as a visceral pain model in the mouse. In addition, the influence of these anticonvulsants on motor performance was examined to compare the tolerability of these anticonvulsants when used against acute visceral pain. METHODS: The antinociceptive effects of these anticonvulsants were examined in the acetic acid writhing test in mice. The side effect propensity of these drugs was examined using the rotarod test. RESULTS: Carbamazepine (25-60 mg/kg; p.o.), oxcarbazepine (10-40 mg/kg; p.o.), gabapentin (10-70 mg/kg; p.o.), and topiramate (5-30 mg/kg; p.o.) caused a significant dose-dependent reduction the number of writhes in the writhing test. In the rotarod test, carbamazepine (60-140 mg/kg; p.o.) and oxcarbazepine (120-450 mg/kg; p.o.) significantly reduced the time spent on the rotarod in a dose- and time-dependent manner. Gabapentin (1000-2000 mg/kg; p.o.) and topiramate (400-1500 mg/kg; p.o.) did not produce significant impairment of motor performance at the highest doses used. The therapeutic index (motor impairing dose TD50)/writhing ED50) values were topiramate (>148.5) > gabapentin (>60.2) > oxcarbazepine (15.2) > carbamazepine (2.3). CONCLUSIONS: These results indicate that oxcarbazepine, gabapentin, and topiramate are effective in the writhing model in mice, in a dose range, which is not related to motor impairment; topiramate is the most potent and the most tolerable drug.", publisher = "Lippincott Williams & Wilkins, Philadelphia", journal = "Anesthesia and Analgesia", title = "The antinociceptive effects of anticonvulsants in a mouse visceral pain model", volume = "106", number = "6", pages = "1897-1903", doi = "10.1213/ane.0b013618172b993" }
Stepanović-Petrović, R., Tomić, M., Vučković, S. M., Paranos, S., Ugrešić, N., Prostran, M., Milovanović, S.,& Bošković, B.. (2008). The antinociceptive effects of anticonvulsants in a mouse visceral pain model. in Anesthesia and Analgesia Lippincott Williams & Wilkins, Philadelphia., 106(6), 1897-1903. https://doi.org/10.1213/ane.0b013618172b993
Stepanović-Petrović R, Tomić M, Vučković SM, Paranos S, Ugrešić N, Prostran M, Milovanović S, Bošković B. The antinociceptive effects of anticonvulsants in a mouse visceral pain model. in Anesthesia and Analgesia. 2008;106(6):1897-1903. doi:10.1213/ane.0b013618172b993 .
Stepanović-Petrović, Radica, Tomić, Maja, Vučković, Sonja M., Paranos, Sonja, Ugrešić, Nenad, Prostran, Milica, Milovanović, Slobocian, Bošković, Bogdan, "The antinociceptive effects of anticonvulsants in a mouse visceral pain model" in Anesthesia and Analgesia, 106, no. 6 (2008):1897-1903, https://doi.org/10.1213/ane.0b013618172b993 . .