Relationships between monoaminergic and cholinergic innervation of the rat thymus during aging
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1994
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The present study has been undertaken in order to investigate whether aging is accompanied by alterations in the thymic autonomic innervation. The results showed that in aged rats compared to young adult rats the density of monoaminergic histofluorescent nerve profiles decreased remarkably, while their pattern of intrathymic distribution remained unchanged. The thymic concentrations of noradrenaline (NA) and dopamine (DA) also significantly decreased between the age of 12 and 18 months. However, the density of thymic autofluorescent cells (afc) markedly increased over the same period, as well as the concentration of 5-hydroxytryptamine (5-HT). The aged rat thymus seemed to be able to maintain its cholinergic innervation in terms of density and pattern of distribution, while the density of cells with intracytoplasmic acetylcholinesterase (AChE) staining even increased. The neurochemical measurement showed an increase in the activity of AChE between the age of 9 to 18 months. The results... indicate an altered relation between the components of thymic autonomic innervation of aged rats that might be related to the reduced immunocompetence of their T cells.
Ključne reči:
Acetylcholinesterase activity / Aging / Monoamine concentration / Rat thymusIzvor:
Journal of Neuroimmunology, 1994, 49, 1-2, 205-212Institucija/grupa
PharmacyTY - JOUR AU - Mićić, M AU - Leposavić, Gordana AU - Ugrešić, Nenad PY - 1994 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/109 AB - The present study has been undertaken in order to investigate whether aging is accompanied by alterations in the thymic autonomic innervation. The results showed that in aged rats compared to young adult rats the density of monoaminergic histofluorescent nerve profiles decreased remarkably, while their pattern of intrathymic distribution remained unchanged. The thymic concentrations of noradrenaline (NA) and dopamine (DA) also significantly decreased between the age of 12 and 18 months. However, the density of thymic autofluorescent cells (afc) markedly increased over the same period, as well as the concentration of 5-hydroxytryptamine (5-HT). The aged rat thymus seemed to be able to maintain its cholinergic innervation in terms of density and pattern of distribution, while the density of cells with intracytoplasmic acetylcholinesterase (AChE) staining even increased. The neurochemical measurement showed an increase in the activity of AChE between the age of 9 to 18 months. The results indicate an altered relation between the components of thymic autonomic innervation of aged rats that might be related to the reduced immunocompetence of their T cells. T2 - Journal of Neuroimmunology T1 - Relationships between monoaminergic and cholinergic innervation of the rat thymus during aging VL - 49 IS - 1-2 SP - 205 EP - 212 DO - 10.1016/0165-5728(94)90197-X ER -
@article{ author = "Mićić, M and Leposavić, Gordana and Ugrešić, Nenad", year = "1994", abstract = "The present study has been undertaken in order to investigate whether aging is accompanied by alterations in the thymic autonomic innervation. The results showed that in aged rats compared to young adult rats the density of monoaminergic histofluorescent nerve profiles decreased remarkably, while their pattern of intrathymic distribution remained unchanged. The thymic concentrations of noradrenaline (NA) and dopamine (DA) also significantly decreased between the age of 12 and 18 months. However, the density of thymic autofluorescent cells (afc) markedly increased over the same period, as well as the concentration of 5-hydroxytryptamine (5-HT). The aged rat thymus seemed to be able to maintain its cholinergic innervation in terms of density and pattern of distribution, while the density of cells with intracytoplasmic acetylcholinesterase (AChE) staining even increased. The neurochemical measurement showed an increase in the activity of AChE between the age of 9 to 18 months. The results indicate an altered relation between the components of thymic autonomic innervation of aged rats that might be related to the reduced immunocompetence of their T cells.", journal = "Journal of Neuroimmunology", title = "Relationships between monoaminergic and cholinergic innervation of the rat thymus during aging", volume = "49", number = "1-2", pages = "205-212", doi = "10.1016/0165-5728(94)90197-X" }
Mićić, M., Leposavić, G.,& Ugrešić, N.. (1994). Relationships between monoaminergic and cholinergic innervation of the rat thymus during aging. in Journal of Neuroimmunology, 49(1-2), 205-212. https://doi.org/10.1016/0165-5728(94)90197-X
Mićić M, Leposavić G, Ugrešić N. Relationships between monoaminergic and cholinergic innervation of the rat thymus during aging. in Journal of Neuroimmunology. 1994;49(1-2):205-212. doi:10.1016/0165-5728(94)90197-X .
Mićić, M, Leposavić, Gordana, Ugrešić, Nenad, "Relationships between monoaminergic and cholinergic innervation of the rat thymus during aging" in Journal of Neuroimmunology, 49, no. 1-2 (1994):205-212, https://doi.org/10.1016/0165-5728(94)90197-X . .