The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems
Abstract
The objective of this study was to develop artificial neural network (ANN) model suitable to predict successfully the borders of the microemulsion region in the quaternary system PEG-8 caprylic/capric glycerides (Labrasol (R)/cosurfactant/isopropyl myristate/water, in order to minimise experimental effort. In our preliminary investigations of phase behaviour, two cosurfactants were used, PEG-40 hydrogenated castor oil (Cremophor (R) RH 40) and polyglyceryl-6 isostearate (Plurol Isostearique (R)). Microemulsion existance area in pseudo-ternary phase diagrams was determined using titration method at constant: (a) oil-to-water ratio (alpha = 50%, w/w); (b) surfactant-to-cosurfactant ratio (Km) 4:6;
Keywords:
artificial neural networks / phase behaviour / microemulsions / Labrasol (R) / Cremophor (R) RH 40 / Plural Isostearique (R)Source:
International Journal of Pharmaceutics, 2008, 361, 1-2, 41-46Publisher:
- Elsevier Science BV, Amsterdam
Funding / projects:
DOI: 10.1016/j.ijpharm.2008.05.002
ISSN: 0378-5173
PubMed: 18571348
WoS: 000258803600007
Scopus: 2-s2.0-48049087191
Collections
Institution/Community
PharmacyTY - JOUR AU - Đekić, Ljiljana AU - Ibrić, Svetlana AU - Primorac, Marija PY - 2008 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1112 AB - The objective of this study was to develop artificial neural network (ANN) model suitable to predict successfully the borders of the microemulsion region in the quaternary system PEG-8 caprylic/capric glycerides (Labrasol (R)/cosurfactant/isopropyl myristate/water, in order to minimise experimental effort. In our preliminary investigations of phase behaviour, two cosurfactants were used, PEG-40 hydrogenated castor oil (Cremophor (R) RH 40) and polyglyceryl-6 isostearate (Plurol Isostearique (R)). Microemulsion existance area in pseudo-ternary phase diagrams was determined using titration method at constant: (a) oil-to-water ratio (alpha = 50%, w/w); (b) surfactant-to-cosurfactant ratio (Km) 4:6; PB - Elsevier Science BV, Amsterdam T2 - International Journal of Pharmaceutics T1 - The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems VL - 361 IS - 1-2 SP - 41 EP - 46 DO - 10.1016/j.ijpharm.2008.05.002 ER -
@article{ author = "Đekić, Ljiljana and Ibrić, Svetlana and Primorac, Marija", year = "2008", abstract = "The objective of this study was to develop artificial neural network (ANN) model suitable to predict successfully the borders of the microemulsion region in the quaternary system PEG-8 caprylic/capric glycerides (Labrasol (R)/cosurfactant/isopropyl myristate/water, in order to minimise experimental effort. In our preliminary investigations of phase behaviour, two cosurfactants were used, PEG-40 hydrogenated castor oil (Cremophor (R) RH 40) and polyglyceryl-6 isostearate (Plurol Isostearique (R)). Microemulsion existance area in pseudo-ternary phase diagrams was determined using titration method at constant: (a) oil-to-water ratio (alpha = 50%, w/w); (b) surfactant-to-cosurfactant ratio (Km) 4:6;", publisher = "Elsevier Science BV, Amsterdam", journal = "International Journal of Pharmaceutics", title = "The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems", volume = "361", number = "1-2", pages = "41-46", doi = "10.1016/j.ijpharm.2008.05.002" }
Đekić, L., Ibrić, S.,& Primorac, M.. (2008). The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems. in International Journal of Pharmaceutics Elsevier Science BV, Amsterdam., 361(1-2), 41-46. https://doi.org/10.1016/j.ijpharm.2008.05.002
Đekić L, Ibrić S, Primorac M. The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems. in International Journal of Pharmaceutics. 2008;361(1-2):41-46. doi:10.1016/j.ijpharm.2008.05.002 .
Đekić, Ljiljana, Ibrić, Svetlana, Primorac, Marija, "The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems" in International Journal of Pharmaceutics, 361, no. 1-2 (2008):41-46, https://doi.org/10.1016/j.ijpharm.2008.05.002 . .