The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems
Само за регистроване кориснике
2008
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The objective of this study was to develop artificial neural network (ANN) model suitable to predict successfully the borders of the microemulsion region in the quaternary system PEG-8 caprylic/capric glycerides (Labrasol (R)/cosurfactant/isopropyl myristate/water, in order to minimise experimental effort. In our preliminary investigations of phase behaviour, two cosurfactants were used, PEG-40 hydrogenated castor oil (Cremophor (R) RH 40) and polyglyceryl-6 isostearate (Plurol Isostearique (R)). Microemulsion existance area in pseudo-ternary phase diagrams was determined using titration method at constant: (a) oil-to-water ratio (alpha = 50%, w/w); (b) surfactant-to-cosurfactant ratio (Km) 4:6;
Кључне речи:
artificial neural networks / phase behaviour / microemulsions / Labrasol (R) / Cremophor (R) RH 40 / Plural Isostearique (R)Извор:
International Journal of Pharmaceutics, 2008, 361, 1-2, 41-46Издавач:
- Elsevier Science BV, Amsterdam
Финансирање / пројекти:
- Синтеза, квантитативни односи између структуре/особина и активности, физичко-хемијска карактеризација и анализа фармаколошки активних супстанци (RS-MESTD-MPN2006-2010-142071)
DOI: 10.1016/j.ijpharm.2008.05.002
ISSN: 0378-5173
PubMed: 18571348
WoS: 000258803600007
Scopus: 2-s2.0-48049087191
Институција/група
PharmacyTY - JOUR AU - Đekić, Ljiljana AU - Ibrić, Svetlana AU - Primorac, Marija PY - 2008 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1112 AB - The objective of this study was to develop artificial neural network (ANN) model suitable to predict successfully the borders of the microemulsion region in the quaternary system PEG-8 caprylic/capric glycerides (Labrasol (R)/cosurfactant/isopropyl myristate/water, in order to minimise experimental effort. In our preliminary investigations of phase behaviour, two cosurfactants were used, PEG-40 hydrogenated castor oil (Cremophor (R) RH 40) and polyglyceryl-6 isostearate (Plurol Isostearique (R)). Microemulsion existance area in pseudo-ternary phase diagrams was determined using titration method at constant: (a) oil-to-water ratio (alpha = 50%, w/w); (b) surfactant-to-cosurfactant ratio (Km) 4:6; PB - Elsevier Science BV, Amsterdam T2 - International Journal of Pharmaceutics T1 - The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems VL - 361 IS - 1-2 SP - 41 EP - 46 DO - 10.1016/j.ijpharm.2008.05.002 ER -
@article{ author = "Đekić, Ljiljana and Ibrić, Svetlana and Primorac, Marija", year = "2008", abstract = "The objective of this study was to develop artificial neural network (ANN) model suitable to predict successfully the borders of the microemulsion region in the quaternary system PEG-8 caprylic/capric glycerides (Labrasol (R)/cosurfactant/isopropyl myristate/water, in order to minimise experimental effort. In our preliminary investigations of phase behaviour, two cosurfactants were used, PEG-40 hydrogenated castor oil (Cremophor (R) RH 40) and polyglyceryl-6 isostearate (Plurol Isostearique (R)). Microemulsion existance area in pseudo-ternary phase diagrams was determined using titration method at constant: (a) oil-to-water ratio (alpha = 50%, w/w); (b) surfactant-to-cosurfactant ratio (Km) 4:6;", publisher = "Elsevier Science BV, Amsterdam", journal = "International Journal of Pharmaceutics", title = "The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems", volume = "361", number = "1-2", pages = "41-46", doi = "10.1016/j.ijpharm.2008.05.002" }
Đekić, L., Ibrić, S.,& Primorac, M.. (2008). The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems. in International Journal of Pharmaceutics Elsevier Science BV, Amsterdam., 361(1-2), 41-46. https://doi.org/10.1016/j.ijpharm.2008.05.002
Đekić L, Ibrić S, Primorac M. The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems. in International Journal of Pharmaceutics. 2008;361(1-2):41-46. doi:10.1016/j.ijpharm.2008.05.002 .
Đekić, Ljiljana, Ibrić, Svetlana, Primorac, Marija, "The application of artificial neural networks in the prediction of microemulsion phase boundaries in PEG-8 caprylic/capric glycerides based systems" in International Journal of Pharmaceutics, 361, no. 1-2 (2008):41-46, https://doi.org/10.1016/j.ijpharm.2008.05.002 . .