Gender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjects
Samo za registrovane korisnike
2008
Autori
Topić, AleksandraSpasojević-Kalimanovska, Vesna
Zeljković, Aleksandra
Vekić, Jelena
Jelić-Ivanović, Zorana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Objectives: We determined the frequencies of apolipoprotein E (apo E) alleles and examined the effect of apo E polymorphism on lipoprotein particle sizes in Serbian healthy, middle-aged individuals. Design and methods: We performed apo E phenotype by immunobloting method in 183 men and 143 women (mean years: 56.3 +/- 10.60 and 54.9 +/- 10.31, respectively). Plasma lipid and apolipoprotein levels were measured by routine laboratory methods. LDL and HDL particle sizes were determined by nondenaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: The apo E allele frequencies were epsilon 2-4.9%, epsilon 3-86.5%, and epsilon 4-8.6%. Men with epsilon 4 allele had lower HDL-C and Apo AI concentrations than epsilon 3 men. The epsilon 2 allele men had the smallest LDL particles, highest percent of subjects with LDL phenotype B and highest TG/HDL-C ratio. Women with epsilon 2 allele had lowest concentration of apo B. The epsilon 4 allele women had smallest HDL particles and high...est percent of the subjects with small-sized HDL phenotype. Conclusions: This study showed gender-related effect of apo E polymorphism on lipoprotein particle size. In men, possession of the 62 allele is associated with small LDL particles, whereas in women, epsilon 4 allele is associated with small HDL particles. Differences in gender-related influence of apo E polymorphism on LDL and HDL particle sizes could be clinically useful in strategy for reduction of coronary disease risk in middle-aged men and women.
Ključne reči:
apo E / polymorphism / LDL particle size / HDL particle sizeIzvor:
Clinical Biochemistry, 2008, 41, 6, 361-367Izdavač:
- Pergamon-Elsevier Science Ltd, Oxford
Finansiranje / projekti:
DOI: 10.1016/j.clinbiochem.2007.11.013
ISSN: 0009-9120
PubMed: 18086568
WoS: 000254648400003
Scopus: 2-s2.0-40849135889
Institucija/grupa
PharmacyTY - JOUR AU - Topić, Aleksandra AU - Spasojević-Kalimanovska, Vesna AU - Zeljković, Aleksandra AU - Vekić, Jelena AU - Jelić-Ivanović, Zorana PY - 2008 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1120 AB - Objectives: We determined the frequencies of apolipoprotein E (apo E) alleles and examined the effect of apo E polymorphism on lipoprotein particle sizes in Serbian healthy, middle-aged individuals. Design and methods: We performed apo E phenotype by immunobloting method in 183 men and 143 women (mean years: 56.3 +/- 10.60 and 54.9 +/- 10.31, respectively). Plasma lipid and apolipoprotein levels were measured by routine laboratory methods. LDL and HDL particle sizes were determined by nondenaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: The apo E allele frequencies were epsilon 2-4.9%, epsilon 3-86.5%, and epsilon 4-8.6%. Men with epsilon 4 allele had lower HDL-C and Apo AI concentrations than epsilon 3 men. The epsilon 2 allele men had the smallest LDL particles, highest percent of subjects with LDL phenotype B and highest TG/HDL-C ratio. Women with epsilon 2 allele had lowest concentration of apo B. The epsilon 4 allele women had smallest HDL particles and highest percent of the subjects with small-sized HDL phenotype. Conclusions: This study showed gender-related effect of apo E polymorphism on lipoprotein particle size. In men, possession of the 62 allele is associated with small LDL particles, whereas in women, epsilon 4 allele is associated with small HDL particles. Differences in gender-related influence of apo E polymorphism on LDL and HDL particle sizes could be clinically useful in strategy for reduction of coronary disease risk in middle-aged men and women. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Clinical Biochemistry T1 - Gender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjects VL - 41 IS - 6 SP - 361 EP - 367 DO - 10.1016/j.clinbiochem.2007.11.013 ER -
@article{ author = "Topić, Aleksandra and Spasojević-Kalimanovska, Vesna and Zeljković, Aleksandra and Vekić, Jelena and Jelić-Ivanović, Zorana", year = "2008", abstract = "Objectives: We determined the frequencies of apolipoprotein E (apo E) alleles and examined the effect of apo E polymorphism on lipoprotein particle sizes in Serbian healthy, middle-aged individuals. Design and methods: We performed apo E phenotype by immunobloting method in 183 men and 143 women (mean years: 56.3 +/- 10.60 and 54.9 +/- 10.31, respectively). Plasma lipid and apolipoprotein levels were measured by routine laboratory methods. LDL and HDL particle sizes were determined by nondenaturing polyacrylamide gradient (3-31%) gel electrophoresis. Results: The apo E allele frequencies were epsilon 2-4.9%, epsilon 3-86.5%, and epsilon 4-8.6%. Men with epsilon 4 allele had lower HDL-C and Apo AI concentrations than epsilon 3 men. The epsilon 2 allele men had the smallest LDL particles, highest percent of subjects with LDL phenotype B and highest TG/HDL-C ratio. Women with epsilon 2 allele had lowest concentration of apo B. The epsilon 4 allele women had smallest HDL particles and highest percent of the subjects with small-sized HDL phenotype. Conclusions: This study showed gender-related effect of apo E polymorphism on lipoprotein particle size. In men, possession of the 62 allele is associated with small LDL particles, whereas in women, epsilon 4 allele is associated with small HDL particles. Differences in gender-related influence of apo E polymorphism on LDL and HDL particle sizes could be clinically useful in strategy for reduction of coronary disease risk in middle-aged men and women.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Clinical Biochemistry", title = "Gender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjects", volume = "41", number = "6", pages = "361-367", doi = "10.1016/j.clinbiochem.2007.11.013" }
Topić, A., Spasojević-Kalimanovska, V., Zeljković, A., Vekić, J.,& Jelić-Ivanović, Z.. (2008). Gender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjects. in Clinical Biochemistry Pergamon-Elsevier Science Ltd, Oxford., 41(6), 361-367. https://doi.org/10.1016/j.clinbiochem.2007.11.013
Topić A, Spasojević-Kalimanovska V, Zeljković A, Vekić J, Jelić-Ivanović Z. Gender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjects. in Clinical Biochemistry. 2008;41(6):361-367. doi:10.1016/j.clinbiochem.2007.11.013 .
Topić, Aleksandra, Spasojević-Kalimanovska, Vesna, Zeljković, Aleksandra, Vekić, Jelena, Jelić-Ivanović, Zorana, "Gender-related effect of apo E polymorphism on lipoprotein particle sizes in the middle-aged subjects" in Clinical Biochemistry, 41, no. 6 (2008):361-367, https://doi.org/10.1016/j.clinbiochem.2007.11.013 . .