Приказ основних података о документу
Penetration and permeation of corticosteroids from pharmaceutical preparations for the skin application
Penetracija i permeacija kortikosteroida iz farmaceutskih preparata za primenu na kožu
dc.creator | Savić, Snežana | |
dc.creator | Vuleta, Gordana | |
dc.date.accessioned | 2019-09-02T11:15:39Z | |
dc.date.available | 2019-09-02T11:15:39Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0004-1963 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1157 | |
dc.description.abstract | As corticosteroids (CS) represent large and significant group of dermatological drugs with a number of indications, performing of in vitro and/or in vivo penetration/permeation studies is of a paramount importance in evaluation of new and generic drugs. Choice of an effective therapeutic dose with acceptable risc/benefit ratio as well as suitable regime of drug use or an adequate vehicle formulation are just some of numerous reasons for employing these studies. One of the current intentions is to improve and standardize in vitro studies with human stratum corneum (SC) or reconstructed human epiderm to reach the comparative level with in vivo evaluation of pharmacodynamic CS response (skin blanchin assay) as well as with tape stripping technique. Skin blanching assay is FDA accepted and approved method for evaluation of bioavailability and bioequivavelence of dermatological CS, with emphasized need for an additional standardization of studies using objective chromametric measurements. Also, actual research activities are directed to further optimization and validation of tape stripping method, as surogate test for studying the bioavailability and bioequivavelence of dermatological drugs and thus locally applied CS. The aim is creating of practical regulatory test, that is a challenge for the future. | en |
dc.description.abstract | Kako kortikosteroidi (KS) predstavljaju veliku i značajnu grupu dermatoloških lekova sa brojnim indikacijama za primenu, sprovođenje in vitro i/ili in vivo studija penetracije/permeacije od velikog je značaja u proceni novih i generičkih lekova. Izbor efikasne terapijske doze sa prihvatljivim odnosom rizik/korist, pogodnog režima primene leka ili najprihvatljivije formulacije nosača su neke od brojnih primena ovih studija. Intencija je da se in vitro studije sa humanim SC-om ili rekonstruisanim humanim epidermom unaprede i standardizuju tako da budu komparativne sa in vivo procenom farmakodinamskog efekta KS (studija izbeljivanja kože) i tehnikom "tape stripping-a". Studija izbeljivanja kože je od FDA prihvaćena i odobrena metoda za procenu bioraspoloživosti i bioekvivalentnosti KS za dermatološku primenu, uz naglašenu potrebu dodatne standardizacije studija u kojima se koriste objektivna hromametrijska merenja. Takođe, trenutno angažovanje istraživača usmereno je ka daljoj optimizaciji i validaciji metode sa trakama (eng. tape stripping), kao "surogat" testu za ispitivanje bioraspoloživosti i biekvivalentnosti dermatoloških lekova, a time i lokalno primenjenih KS. Cilj je koncipiranje praktičnog regulatorno prihvaćenog testa, što je izazov za budućnost. | sr |
dc.publisher | Savez farmaceutskih udruženja Srbije, Beograd | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-sa/4.0/ | |
dc.source | Arhiv za farmaciju | |
dc.subject | corticosteroid | en |
dc.subject | penetration | en |
dc.subject | permeation | en |
dc.subject | in vitro | en |
dc.subject | in vivo | en |
dc.subject | human SC | en |
dc.subject | reconstructed human epiderm | en |
dc.subject | skin blanching assay | en |
dc.subject | tape stripping method | en |
dc.subject | kortikosteroid | sr |
dc.subject | penetracija | sr |
dc.subject | permeacija | sr |
dc.subject | in vitro | sr |
dc.subject | in vivo | sr |
dc.subject | humani SC | sr |
dc.subject | rekonstruisani humani epiderm | sr |
dc.subject | metoda izbeljivanja kože | sr |
dc.subject | metoda sa trakama | sr |
dc.title | Penetration and permeation of corticosteroids from pharmaceutical preparations for the skin application | en |
dc.title | Penetracija i permeacija kortikosteroida iz farmaceutskih preparata za primenu na kožu | sr |
dc.type | article | |
dc.rights.license | BY-SA | |
dcterms.abstract | Савић, Снежана; Вулета, Гордана; Пенетрација и пермеација кортикостероида из фармацеутских препарата за примену на кожу; Пенетрација и пермеација кортикостероида из фармацеутских препарата за примену на кожу; | |
dc.citation.volume | 58 | |
dc.citation.issue | 2-3 | |
dc.citation.spage | 153 | |
dc.citation.epage | 171 | |
dc.citation.other | 58(2-3): 153-171 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/126/1155.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_1157 | |
dc.type.version | publishedVersion |