Circulating sTWEAK improves the prediction of coronary artery disease
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2009
Authors
Jelić-Ivanović, ZoranaBujisić, Nada
Spasić, Slavica
Bogavac-Stanojević, Nataša
Spasojević-Kalimanovska, Vesna
Kotur-Stevuljević, Jelena
Article (Published version)
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Objectives: Decreased concentrations of circulating soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) were recently reported to be associated with atherosclerosis, but there are still no data concerning its predictive performance. Design and methods: The current cross-sectional study investigates the potential of the novel atherosclerotic biomarker for the prediction of coronary artery disease (CAD). Serum sTWEAK was measured by ELISA in 76 CAD patients and 82 CAD-free subjects. Results: Serum sTWEAK concentrations were significantly lower in the patients (534.5 +/- 110.9 mu g/L) than in the controls (688.1 +/- 150.0 mu g/L, p lt 0.001), even after adjusting for different confounders (p lt 0.001). The areas under ROC curves (AUC)s calculated for logistic regression models that included different known risk factors were significantly increased when sTWEAK was added to the corresponding model (p = 0.011-0.035). Conclusions: The measurement of serum sTWEAK concentr...ations improves the prediction of CAD based on existing biomarkers.
Keywords:
Atherosclerosis / Risk factors / Coronary artery disease / ROC curve analysis / Biomarkers / sTWEAKSource:
Clinical Biochemistry, 2009, 42, 13-14, 1381-1386Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
Funding / projects:
- Ispitivanje biohemijskih i genetičkih faktora rizika kao uzročnika i markera ateroskleroze i drugih oboljenja: analitički i klinički aspekti (RS-MESTD-MPN2006-2010-145036)
DOI: 10.1016/j.clinbiochem.2009.06.001
ISSN: 0009-9120
PubMed: 19505454
WoS: 000272261800008
Scopus: 2-s2.0-69249205389
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Institution/Community
PharmacyTY - JOUR AU - Jelić-Ivanović, Zorana AU - Bujisić, Nada AU - Spasić, Slavica AU - Bogavac-Stanojević, Nataša AU - Spasojević-Kalimanovska, Vesna AU - Kotur-Stevuljević, Jelena PY - 2009 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1210 AB - Objectives: Decreased concentrations of circulating soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) were recently reported to be associated with atherosclerosis, but there are still no data concerning its predictive performance. Design and methods: The current cross-sectional study investigates the potential of the novel atherosclerotic biomarker for the prediction of coronary artery disease (CAD). Serum sTWEAK was measured by ELISA in 76 CAD patients and 82 CAD-free subjects. Results: Serum sTWEAK concentrations were significantly lower in the patients (534.5 +/- 110.9 mu g/L) than in the controls (688.1 +/- 150.0 mu g/L, p lt 0.001), even after adjusting for different confounders (p lt 0.001). The areas under ROC curves (AUC)s calculated for logistic regression models that included different known risk factors were significantly increased when sTWEAK was added to the corresponding model (p = 0.011-0.035). Conclusions: The measurement of serum sTWEAK concentrations improves the prediction of CAD based on existing biomarkers. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Clinical Biochemistry T1 - Circulating sTWEAK improves the prediction of coronary artery disease VL - 42 IS - 13-14 SP - 1381 EP - 1386 DO - 10.1016/j.clinbiochem.2009.06.001 ER -
@article{ author = "Jelić-Ivanović, Zorana and Bujisić, Nada and Spasić, Slavica and Bogavac-Stanojević, Nataša and Spasojević-Kalimanovska, Vesna and Kotur-Stevuljević, Jelena", year = "2009", abstract = "Objectives: Decreased concentrations of circulating soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) were recently reported to be associated with atherosclerosis, but there are still no data concerning its predictive performance. Design and methods: The current cross-sectional study investigates the potential of the novel atherosclerotic biomarker for the prediction of coronary artery disease (CAD). Serum sTWEAK was measured by ELISA in 76 CAD patients and 82 CAD-free subjects. Results: Serum sTWEAK concentrations were significantly lower in the patients (534.5 +/- 110.9 mu g/L) than in the controls (688.1 +/- 150.0 mu g/L, p lt 0.001), even after adjusting for different confounders (p lt 0.001). The areas under ROC curves (AUC)s calculated for logistic regression models that included different known risk factors were significantly increased when sTWEAK was added to the corresponding model (p = 0.011-0.035). Conclusions: The measurement of serum sTWEAK concentrations improves the prediction of CAD based on existing biomarkers.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Clinical Biochemistry", title = "Circulating sTWEAK improves the prediction of coronary artery disease", volume = "42", number = "13-14", pages = "1381-1386", doi = "10.1016/j.clinbiochem.2009.06.001" }
Jelić-Ivanović, Z., Bujisić, N., Spasić, S., Bogavac-Stanojević, N., Spasojević-Kalimanovska, V.,& Kotur-Stevuljević, J.. (2009). Circulating sTWEAK improves the prediction of coronary artery disease. in Clinical Biochemistry Pergamon-Elsevier Science Ltd, Oxford., 42(13-14), 1381-1386. https://doi.org/10.1016/j.clinbiochem.2009.06.001
Jelić-Ivanović Z, Bujisić N, Spasić S, Bogavac-Stanojević N, Spasojević-Kalimanovska V, Kotur-Stevuljević J. Circulating sTWEAK improves the prediction of coronary artery disease. in Clinical Biochemistry. 2009;42(13-14):1381-1386. doi:10.1016/j.clinbiochem.2009.06.001 .
Jelić-Ivanović, Zorana, Bujisić, Nada, Spasić, Slavica, Bogavac-Stanojević, Nataša, Spasojević-Kalimanovska, Vesna, Kotur-Stevuljević, Jelena, "Circulating sTWEAK improves the prediction of coronary artery disease" in Clinical Biochemistry, 42, no. 13-14 (2009):1381-1386, https://doi.org/10.1016/j.clinbiochem.2009.06.001 . .