Temoporfin-loaded liposomal gels: Viscoelastic properties and in vitro skin penetration
Само за регистроване кориснике
2009
Аутори
Dragičević-Curić, NinaWinter, Sven
Stupar, Mirjana
Milić, Jela
Krajišnik, Danina
Gitter, Burkhard
Fahr, Alfred
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Temoporfin (mTHPC) is a potent second-generation photosensitizer. The primary object of this study was to develop a topical mTHPC-loaded liposomal hydrogel able to deliver mTHPC into the stratum corneum (SC) and deeper skin layers. This study was conducted (1) to determine the effect of carbomer concentration, used as a gelling agent, and the effect of phosphatidylcholine (PC) content of lecithin, used for the liposome preparation. on viscoelastic properties and viscosity of liposomal gels and (2) to determine the relationship between theological properties of gels and the skin penetration of mTHPC. Liposomal hydrogels revealed plastic flow behaviour. The increase of carbomer concentration induced a domination of elastic over viscous behaviour of gels. There was an inverse relationship between the elasticity of gels and mTHPC-penetration. Viscosity also increased with the increment of carbomer concentration, reducing the mTHPC-penetration. Liposomal gels containing lecithin of smaller ...PC-content (i.e. smaller purity) exhibited a more elastic solid behaviour than gels containing lecithin with high PC-content, and showed smaller mTHPC-penetration. The gel containing 0.75%, w/w, carbomer and lecithin with high PC-content was considered to be the optimal formulation, since it delivered high amounts of mTHPC to the SC and deeper skin layers, and it possessed desirable theological properties.
Кључне речи:
Temoporfin / Liposome / Liposomal hydrogel / Carbomer / Skin penetration / Viscoelastic propertiesИзвор:
International Journal of Pharmaceutics, 2009, 373, 1-2, 77-84Издавач:
- Elsevier Science BV, Amsterdam
DOI: 10.1016/j.ijpharm.2009.02.010
ISSN: 0378-5173
PubMed: 19429291
WoS: 000266307100011
Scopus: 2-s2.0-67349134179
Институција/група
PharmacyTY - JOUR AU - Dragičević-Curić, Nina AU - Winter, Sven AU - Stupar, Mirjana AU - Milić, Jela AU - Krajišnik, Danina AU - Gitter, Burkhard AU - Fahr, Alfred PY - 2009 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1231 AB - Temoporfin (mTHPC) is a potent second-generation photosensitizer. The primary object of this study was to develop a topical mTHPC-loaded liposomal hydrogel able to deliver mTHPC into the stratum corneum (SC) and deeper skin layers. This study was conducted (1) to determine the effect of carbomer concentration, used as a gelling agent, and the effect of phosphatidylcholine (PC) content of lecithin, used for the liposome preparation. on viscoelastic properties and viscosity of liposomal gels and (2) to determine the relationship between theological properties of gels and the skin penetration of mTHPC. Liposomal hydrogels revealed plastic flow behaviour. The increase of carbomer concentration induced a domination of elastic over viscous behaviour of gels. There was an inverse relationship between the elasticity of gels and mTHPC-penetration. Viscosity also increased with the increment of carbomer concentration, reducing the mTHPC-penetration. Liposomal gels containing lecithin of smaller PC-content (i.e. smaller purity) exhibited a more elastic solid behaviour than gels containing lecithin with high PC-content, and showed smaller mTHPC-penetration. The gel containing 0.75%, w/w, carbomer and lecithin with high PC-content was considered to be the optimal formulation, since it delivered high amounts of mTHPC to the SC and deeper skin layers, and it possessed desirable theological properties. PB - Elsevier Science BV, Amsterdam T2 - International Journal of Pharmaceutics T1 - Temoporfin-loaded liposomal gels: Viscoelastic properties and in vitro skin penetration VL - 373 IS - 1-2 SP - 77 EP - 84 DO - 10.1016/j.ijpharm.2009.02.010 ER -
@article{ author = "Dragičević-Curić, Nina and Winter, Sven and Stupar, Mirjana and Milić, Jela and Krajišnik, Danina and Gitter, Burkhard and Fahr, Alfred", year = "2009", abstract = "Temoporfin (mTHPC) is a potent second-generation photosensitizer. The primary object of this study was to develop a topical mTHPC-loaded liposomal hydrogel able to deliver mTHPC into the stratum corneum (SC) and deeper skin layers. This study was conducted (1) to determine the effect of carbomer concentration, used as a gelling agent, and the effect of phosphatidylcholine (PC) content of lecithin, used for the liposome preparation. on viscoelastic properties and viscosity of liposomal gels and (2) to determine the relationship between theological properties of gels and the skin penetration of mTHPC. Liposomal hydrogels revealed plastic flow behaviour. The increase of carbomer concentration induced a domination of elastic over viscous behaviour of gels. There was an inverse relationship between the elasticity of gels and mTHPC-penetration. Viscosity also increased with the increment of carbomer concentration, reducing the mTHPC-penetration. Liposomal gels containing lecithin of smaller PC-content (i.e. smaller purity) exhibited a more elastic solid behaviour than gels containing lecithin with high PC-content, and showed smaller mTHPC-penetration. The gel containing 0.75%, w/w, carbomer and lecithin with high PC-content was considered to be the optimal formulation, since it delivered high amounts of mTHPC to the SC and deeper skin layers, and it possessed desirable theological properties.", publisher = "Elsevier Science BV, Amsterdam", journal = "International Journal of Pharmaceutics", title = "Temoporfin-loaded liposomal gels: Viscoelastic properties and in vitro skin penetration", volume = "373", number = "1-2", pages = "77-84", doi = "10.1016/j.ijpharm.2009.02.010" }
Dragičević-Curić, N., Winter, S., Stupar, M., Milić, J., Krajišnik, D., Gitter, B.,& Fahr, A.. (2009). Temoporfin-loaded liposomal gels: Viscoelastic properties and in vitro skin penetration. in International Journal of Pharmaceutics Elsevier Science BV, Amsterdam., 373(1-2), 77-84. https://doi.org/10.1016/j.ijpharm.2009.02.010
Dragičević-Curić N, Winter S, Stupar M, Milić J, Krajišnik D, Gitter B, Fahr A. Temoporfin-loaded liposomal gels: Viscoelastic properties and in vitro skin penetration. in International Journal of Pharmaceutics. 2009;373(1-2):77-84. doi:10.1016/j.ijpharm.2009.02.010 .
Dragičević-Curić, Nina, Winter, Sven, Stupar, Mirjana, Milić, Jela, Krajišnik, Danina, Gitter, Burkhard, Fahr, Alfred, "Temoporfin-loaded liposomal gels: Viscoelastic properties and in vitro skin penetration" in International Journal of Pharmaceutics, 373, no. 1-2 (2009):77-84, https://doi.org/10.1016/j.ijpharm.2009.02.010 . .