Combined Effects of Small Apolipoprotein (a) Isoforms and Small, Dense LDL on Coronary Artery Disease Risk
Само за регистроване кориснике
2009
Аутори
Zeljković, AleksandraBogavac-Stanojević, Nataša
Jelić-Ivanović, Zorana
Spasojević-Kalimanovska, Vesna
Vekić, Jelena
Spasić, Slavica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background and Aims. Lipoprotein (a) [Lp(a)] consists of low-density lipoprotein (LDL) and apolipoprotein (a) [apo(a)]. Both Lp(a) constituents are well-recognized risk factors for coronary artery disease (CAD). This study investigates the interrelationship of apo(a) and LDL size, as well as their possible synergistic effect on the increase of CAD risk. Methods. One hundred nine CAD patients and 102 apparently healthy subjects were included in the study. Lp(a) concentration was measured using immunoturbidimetry. The sizes of apo(a) isoforms were determined by SDS-agarose gel electrophoresis followed by immunoblotting. LDL particle size was determined by gradient gel electrophoresis. Results. We found an inverse correlation between apo(a) size and Lp(a) concentration (r(2) = 31% p lt 0.001 in the control group and r(2) = 35%. p lt 0.001 in the CAD group). Individuals with smaller apo(a) isoforms and small, dense LDL (sdLDL) > 50% had the highest risk of CAD development (OR = 4.23, p =... 0.017). The synergy index (SIM) for the combination of smaller apo(a) isoforms and sdLDL > 50% was 1.2. Adjustment for Lp(a) and triacylglycerol concentrations eliminated smaller apo(a)/sdLDL > 50% related risk (1) = 0.233 and p = 0.09, respectively). Conclusions. Smaller apo(a) isoforms appear to be superior to sdLDL for the assessment of CAD risk. Their combined effect is synergistic.
Кључне речи:
Apolipoprotein (a) / Small dense LDL / Coronary artery diseaseИзвор:
Archives of Medical Research, 2009, 40, 1, 29-35Издавач:
- Elsevier Science Inc, New York
Финансирање / пројекти:
- Испитивање биохемијских и генетичких фактора ризика као узрочника и маркера атеросклерозе и других обољења: аналитички и клинички аспекти (RS-MESTD-MPN2006-2010-145036)
DOI: 10.1016/j.arcmed.2008.10.010
ISSN: 0188-4409
PubMed: 19064124
WoS: 000261964400005
Scopus: 2-s2.0-57149107816
Институција/група
PharmacyTY - JOUR AU - Zeljković, Aleksandra AU - Bogavac-Stanojević, Nataša AU - Jelić-Ivanović, Zorana AU - Spasojević-Kalimanovska, Vesna AU - Vekić, Jelena AU - Spasić, Slavica PY - 2009 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1235 AB - Background and Aims. Lipoprotein (a) [Lp(a)] consists of low-density lipoprotein (LDL) and apolipoprotein (a) [apo(a)]. Both Lp(a) constituents are well-recognized risk factors for coronary artery disease (CAD). This study investigates the interrelationship of apo(a) and LDL size, as well as their possible synergistic effect on the increase of CAD risk. Methods. One hundred nine CAD patients and 102 apparently healthy subjects were included in the study. Lp(a) concentration was measured using immunoturbidimetry. The sizes of apo(a) isoforms were determined by SDS-agarose gel electrophoresis followed by immunoblotting. LDL particle size was determined by gradient gel electrophoresis. Results. We found an inverse correlation between apo(a) size and Lp(a) concentration (r(2) = 31% p lt 0.001 in the control group and r(2) = 35%. p lt 0.001 in the CAD group). Individuals with smaller apo(a) isoforms and small, dense LDL (sdLDL) > 50% had the highest risk of CAD development (OR = 4.23, p = 0.017). The synergy index (SIM) for the combination of smaller apo(a) isoforms and sdLDL > 50% was 1.2. Adjustment for Lp(a) and triacylglycerol concentrations eliminated smaller apo(a)/sdLDL > 50% related risk (1) = 0.233 and p = 0.09, respectively). Conclusions. Smaller apo(a) isoforms appear to be superior to sdLDL for the assessment of CAD risk. Their combined effect is synergistic. PB - Elsevier Science Inc, New York T2 - Archives of Medical Research T1 - Combined Effects of Small Apolipoprotein (a) Isoforms and Small, Dense LDL on Coronary Artery Disease Risk VL - 40 IS - 1 SP - 29 EP - 35 DO - 10.1016/j.arcmed.2008.10.010 ER -
@article{ author = "Zeljković, Aleksandra and Bogavac-Stanojević, Nataša and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Vekić, Jelena and Spasić, Slavica", year = "2009", abstract = "Background and Aims. Lipoprotein (a) [Lp(a)] consists of low-density lipoprotein (LDL) and apolipoprotein (a) [apo(a)]. Both Lp(a) constituents are well-recognized risk factors for coronary artery disease (CAD). This study investigates the interrelationship of apo(a) and LDL size, as well as their possible synergistic effect on the increase of CAD risk. Methods. One hundred nine CAD patients and 102 apparently healthy subjects were included in the study. Lp(a) concentration was measured using immunoturbidimetry. The sizes of apo(a) isoforms were determined by SDS-agarose gel electrophoresis followed by immunoblotting. LDL particle size was determined by gradient gel electrophoresis. Results. We found an inverse correlation between apo(a) size and Lp(a) concentration (r(2) = 31% p lt 0.001 in the control group and r(2) = 35%. p lt 0.001 in the CAD group). Individuals with smaller apo(a) isoforms and small, dense LDL (sdLDL) > 50% had the highest risk of CAD development (OR = 4.23, p = 0.017). The synergy index (SIM) for the combination of smaller apo(a) isoforms and sdLDL > 50% was 1.2. Adjustment for Lp(a) and triacylglycerol concentrations eliminated smaller apo(a)/sdLDL > 50% related risk (1) = 0.233 and p = 0.09, respectively). Conclusions. Smaller apo(a) isoforms appear to be superior to sdLDL for the assessment of CAD risk. Their combined effect is synergistic.", publisher = "Elsevier Science Inc, New York", journal = "Archives of Medical Research", title = "Combined Effects of Small Apolipoprotein (a) Isoforms and Small, Dense LDL on Coronary Artery Disease Risk", volume = "40", number = "1", pages = "29-35", doi = "10.1016/j.arcmed.2008.10.010" }
Zeljković, A., Bogavac-Stanojević, N., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Vekić, J.,& Spasić, S.. (2009). Combined Effects of Small Apolipoprotein (a) Isoforms and Small, Dense LDL on Coronary Artery Disease Risk. in Archives of Medical Research Elsevier Science Inc, New York., 40(1), 29-35. https://doi.org/10.1016/j.arcmed.2008.10.010
Zeljković A, Bogavac-Stanojević N, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Vekić J, Spasić S. Combined Effects of Small Apolipoprotein (a) Isoforms and Small, Dense LDL on Coronary Artery Disease Risk. in Archives of Medical Research. 2009;40(1):29-35. doi:10.1016/j.arcmed.2008.10.010 .
Zeljković, Aleksandra, Bogavac-Stanojević, Nataša, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Vekić, Jelena, Spasić, Slavica, "Combined Effects of Small Apolipoprotein (a) Isoforms and Small, Dense LDL on Coronary Artery Disease Risk" in Archives of Medical Research, 40, no. 1 (2009):29-35, https://doi.org/10.1016/j.arcmed.2008.10.010 . .