Chemometrical evaluation of ropinirole and its impurity's chromatographic behavior
Abstract
The aim of this study was the chemometrical evaluation of ropinirole and its impurity's (4-[2(dipropylamino)ethyl]-1H-indol-2,3-dione) chromatographic behavior in systematic and the most efficient way. For that purpose, as very descriptive, response surface designs are most preferable. Face-centered central composite design (CCD) with 2(3) full factorial design, +/- 1 star design and four replication in central point was applied for a response surface study, in order to examine in depth the effects of the most important factors. Factors-independent variables (acetonitrile content, pH of the mobile phase and concentration of sodium heptane sulfonate in water phase) were extracted from the preliminary study and as dependent variables five responses (retention factor of ropinirole, retentin factor of its impurity, resolution, symmetry of ropinirole peak and symmetry of impurity peak) were selected. For the improvement of method development and optimization step, Derringer's desirability f...unction was applied to simultaneously optimize the five chosen responses. The procedure allowed deduction of optimal conditions and the predicted optimum was acetonitrile-5 mM of sodium heptane sulfonate (21.6:78.4, v/v), pH of the mobile phase adjusted at 2.0 with ortho phosphoric acid. By calculating global desirability's determination coefficients (R-D(2)), as well as by the visual inspection of 3D graphs for global desirability, robustness of the proposed method was also estimated.
Keywords:
Ropinirole and its impurity / Central composite design / Multicriteria decision making / Derringer's desirability function / Robustness testingSource:
Journal of Chromatography A, 2009, 1216, 8, 1263-1269Publisher:
- Elsevier Science BV, Amsterdam
Funding / projects:
- Formulisanje i Karakterizacija separacionih sistema za modelovanje retencionog ponašanja lekovitih supstancija uz hemometrijsku evaluaciju (RS-MESTD-MPN2006-2010-142077)
DOI: 10.1016/j.chroma.2008.10.059
ISSN: 0021-9673
PubMed: 18976771
WoS: 000263740300007
Scopus: 2-s2.0-58949097539
Collections
Institution/Community
PharmacyTY - JOUR AU - Jančić-Stojanović, Biljana AU - Malenović, Anđelija AU - Ivanović, D. AU - Rakić, Tijana AU - Medenica, Mirjana PY - 2009 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1250 AB - The aim of this study was the chemometrical evaluation of ropinirole and its impurity's (4-[2(dipropylamino)ethyl]-1H-indol-2,3-dione) chromatographic behavior in systematic and the most efficient way. For that purpose, as very descriptive, response surface designs are most preferable. Face-centered central composite design (CCD) with 2(3) full factorial design, +/- 1 star design and four replication in central point was applied for a response surface study, in order to examine in depth the effects of the most important factors. Factors-independent variables (acetonitrile content, pH of the mobile phase and concentration of sodium heptane sulfonate in water phase) were extracted from the preliminary study and as dependent variables five responses (retention factor of ropinirole, retentin factor of its impurity, resolution, symmetry of ropinirole peak and symmetry of impurity peak) were selected. For the improvement of method development and optimization step, Derringer's desirability function was applied to simultaneously optimize the five chosen responses. The procedure allowed deduction of optimal conditions and the predicted optimum was acetonitrile-5 mM of sodium heptane sulfonate (21.6:78.4, v/v), pH of the mobile phase adjusted at 2.0 with ortho phosphoric acid. By calculating global desirability's determination coefficients (R-D(2)), as well as by the visual inspection of 3D graphs for global desirability, robustness of the proposed method was also estimated. PB - Elsevier Science BV, Amsterdam T2 - Journal of Chromatography A T1 - Chemometrical evaluation of ropinirole and its impurity's chromatographic behavior VL - 1216 IS - 8 SP - 1263 EP - 1269 DO - 10.1016/j.chroma.2008.10.059 ER -
@article{ author = "Jančić-Stojanović, Biljana and Malenović, Anđelija and Ivanović, D. and Rakić, Tijana and Medenica, Mirjana", year = "2009", abstract = "The aim of this study was the chemometrical evaluation of ropinirole and its impurity's (4-[2(dipropylamino)ethyl]-1H-indol-2,3-dione) chromatographic behavior in systematic and the most efficient way. For that purpose, as very descriptive, response surface designs are most preferable. Face-centered central composite design (CCD) with 2(3) full factorial design, +/- 1 star design and four replication in central point was applied for a response surface study, in order to examine in depth the effects of the most important factors. Factors-independent variables (acetonitrile content, pH of the mobile phase and concentration of sodium heptane sulfonate in water phase) were extracted from the preliminary study and as dependent variables five responses (retention factor of ropinirole, retentin factor of its impurity, resolution, symmetry of ropinirole peak and symmetry of impurity peak) were selected. For the improvement of method development and optimization step, Derringer's desirability function was applied to simultaneously optimize the five chosen responses. The procedure allowed deduction of optimal conditions and the predicted optimum was acetonitrile-5 mM of sodium heptane sulfonate (21.6:78.4, v/v), pH of the mobile phase adjusted at 2.0 with ortho phosphoric acid. By calculating global desirability's determination coefficients (R-D(2)), as well as by the visual inspection of 3D graphs for global desirability, robustness of the proposed method was also estimated.", publisher = "Elsevier Science BV, Amsterdam", journal = "Journal of Chromatography A", title = "Chemometrical evaluation of ropinirole and its impurity's chromatographic behavior", volume = "1216", number = "8", pages = "1263-1269", doi = "10.1016/j.chroma.2008.10.059" }
Jančić-Stojanović, B., Malenović, A., Ivanović, D., Rakić, T.,& Medenica, M.. (2009). Chemometrical evaluation of ropinirole and its impurity's chromatographic behavior. in Journal of Chromatography A Elsevier Science BV, Amsterdam., 1216(8), 1263-1269. https://doi.org/10.1016/j.chroma.2008.10.059
Jančić-Stojanović B, Malenović A, Ivanović D, Rakić T, Medenica M. Chemometrical evaluation of ropinirole and its impurity's chromatographic behavior. in Journal of Chromatography A. 2009;1216(8):1263-1269. doi:10.1016/j.chroma.2008.10.059 .
Jančić-Stojanović, Biljana, Malenović, Anđelija, Ivanović, D., Rakić, Tijana, Medenica, Mirjana, "Chemometrical evaluation of ropinirole and its impurity's chromatographic behavior" in Journal of Chromatography A, 1216, no. 8 (2009):1263-1269, https://doi.org/10.1016/j.chroma.2008.10.059 . .