An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design
Само за регистроване кориснике
2009
Аутори
Petrović, AleksandraIbrić, Svetlana
Trajković, Svetlana
Popović, Radmila
Đurić, Zorica
Popadić, Dragica
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The purpose of this study was to investigate the effect of various in vitro test conditions, on the release properties of theophylline (TP) from aminophylline (AP) matrices based on different hydroxypropylmethylcellulose (HPMC) ratio and viscosity grades. The General full factorial experimental design 3 x 3 x 3 was used, based on three independent variables: applied in vitro test (X1), HPMC/drug ratio (X2) and polymer viscosity grade (X3). The drug release percent at 2h (Y-2h), 4h (Y-4h) and 8 h (Y-8h) and time for 50% of TP release from matrices (Y-T50%) were response variables. Three in vitro tests were used: Test 1 and Test 4 (Theophylline Extended-release Capsules, USP 30) and Half-change method. According to factorial design analyses, in vitro test was the most significant factor influencing mechanism and amount of drug release. For Half Change method erosion was the predominant mechanism indicating Case - II transport, while for Test 1 the release mechanism were followed by both ...diffusion and erosion. The lowest release exponent n values, obtained from Ritger-Pepass equation, for Test 4 indicate diffusion process inclining from Fickian diffusion to Anomalous transport. Therefore, it is in the stage of development, useful to consider the influence of various in vitro test conditions on the formulation, in order to choose an optimal test for the purpose of future drug release examination.
Кључне речи:
Sustained release dosage form / In vitro tests / General experimental design / Dissolution / Diffusion-erosion kineticsИзвор:
Archives of Pharmacal Research, 2009, 32, 7, 1087-1096Издавач:
- Pharmaceutical Soc Korea, Seoul
Финансирање / пројекти:
- Ministry of Science and Environmental Protection, Republic of Serbia - 6719B
DOI: 10.1007/s12272-009-1715-y
ISSN: 0253-6269
PubMed: 19641891
WoS: 000268511000017
Scopus: 2-s2.0-68649103530
Институција/група
PharmacyTY - JOUR AU - Petrović, Aleksandra AU - Ibrić, Svetlana AU - Trajković, Svetlana AU - Popović, Radmila AU - Đurić, Zorica AU - Popadić, Dragica PY - 2009 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1284 AB - The purpose of this study was to investigate the effect of various in vitro test conditions, on the release properties of theophylline (TP) from aminophylline (AP) matrices based on different hydroxypropylmethylcellulose (HPMC) ratio and viscosity grades. The General full factorial experimental design 3 x 3 x 3 was used, based on three independent variables: applied in vitro test (X1), HPMC/drug ratio (X2) and polymer viscosity grade (X3). The drug release percent at 2h (Y-2h), 4h (Y-4h) and 8 h (Y-8h) and time for 50% of TP release from matrices (Y-T50%) were response variables. Three in vitro tests were used: Test 1 and Test 4 (Theophylline Extended-release Capsules, USP 30) and Half-change method. According to factorial design analyses, in vitro test was the most significant factor influencing mechanism and amount of drug release. For Half Change method erosion was the predominant mechanism indicating Case - II transport, while for Test 1 the release mechanism were followed by both diffusion and erosion. The lowest release exponent n values, obtained from Ritger-Pepass equation, for Test 4 indicate diffusion process inclining from Fickian diffusion to Anomalous transport. Therefore, it is in the stage of development, useful to consider the influence of various in vitro test conditions on the formulation, in order to choose an optimal test for the purpose of future drug release examination. PB - Pharmaceutical Soc Korea, Seoul T2 - Archives of Pharmacal Research T1 - An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design VL - 32 IS - 7 SP - 1087 EP - 1096 DO - 10.1007/s12272-009-1715-y ER -
@article{ author = "Petrović, Aleksandra and Ibrić, Svetlana and Trajković, Svetlana and Popović, Radmila and Đurić, Zorica and Popadić, Dragica", year = "2009", abstract = "The purpose of this study was to investigate the effect of various in vitro test conditions, on the release properties of theophylline (TP) from aminophylline (AP) matrices based on different hydroxypropylmethylcellulose (HPMC) ratio and viscosity grades. The General full factorial experimental design 3 x 3 x 3 was used, based on three independent variables: applied in vitro test (X1), HPMC/drug ratio (X2) and polymer viscosity grade (X3). The drug release percent at 2h (Y-2h), 4h (Y-4h) and 8 h (Y-8h) and time for 50% of TP release from matrices (Y-T50%) were response variables. Three in vitro tests were used: Test 1 and Test 4 (Theophylline Extended-release Capsules, USP 30) and Half-change method. According to factorial design analyses, in vitro test was the most significant factor influencing mechanism and amount of drug release. For Half Change method erosion was the predominant mechanism indicating Case - II transport, while for Test 1 the release mechanism were followed by both diffusion and erosion. The lowest release exponent n values, obtained from Ritger-Pepass equation, for Test 4 indicate diffusion process inclining from Fickian diffusion to Anomalous transport. Therefore, it is in the stage of development, useful to consider the influence of various in vitro test conditions on the formulation, in order to choose an optimal test for the purpose of future drug release examination.", publisher = "Pharmaceutical Soc Korea, Seoul", journal = "Archives of Pharmacal Research", title = "An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design", volume = "32", number = "7", pages = "1087-1096", doi = "10.1007/s12272-009-1715-y" }
Petrović, A., Ibrić, S., Trajković, S., Popović, R., Đurić, Z.,& Popadić, D.. (2009). An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design. in Archives of Pharmacal Research Pharmaceutical Soc Korea, Seoul., 32(7), 1087-1096. https://doi.org/10.1007/s12272-009-1715-y
Petrović A, Ibrić S, Trajković S, Popović R, Đurić Z, Popadić D. An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design. in Archives of Pharmacal Research. 2009;32(7):1087-1096. doi:10.1007/s12272-009-1715-y .
Petrović, Aleksandra, Ibrić, Svetlana, Trajković, Svetlana, Popović, Radmila, Đurić, Zorica, Popadić, Dragica, "An investigation into effects of In Vitro Test condition on the release properties of theophylline from HPMC matrices using factorial design" in Archives of Pharmacal Research, 32, no. 7 (2009):1087-1096, https://doi.org/10.1007/s12272-009-1715-y . .