Forced degradation studies of simvastatin using microemulsion liquid chromatography
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2010
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
In this paper, the definition of simvastatin degradation profile by microemulsion liquid chromatography (MELC) is presented. The aim of the study was to investigate simvastatin stability after various stress tests, such as: acid and base hydrolysis, oxidation, and heat. The kinetics of acid and oxidative degradation was also studied. The complex retention mechanism occurring when microemulsion is used as eluent enabled the successful separation of a large number of degradants in prepared stress samples. The existence of a second partitioning site due to microstructural and interfacial characteristics of o/w microemulsion eluent facilitated HPLC separation. All the expected capabilities of MELC method were realized, demonstrating the advantage and value of the MELC method for a wide area of pharmaceutical analysis. For acid degradation the second order rate constant and half-life were calculated. Oxidative decomposition proved to be the first order reaction for which the rate constant a...nd half-life were also determined.
Ključne reči:
forced degradation studies / kinetic study / microemulsion liquid chromatography / simvastatinIzvor:
Journal of Liquid Chromatography & Related Technologies, 2010, 33, 4, 536-547Izdavač:
- Taylor & Francis Inc, Philadelphia
Finansiranje / projekti:
DOI: 10.1080/10826070903574576
ISSN: 1082-6076
WoS: 000274536100011
Scopus: 2-s2.0-76749098168
Institucija/grupa
PharmacyTY - JOUR AU - Malenović, Anđelija AU - Jančić-Stojanović, Biljana AU - Ivanović, Darko AU - Medenica, Mirjana PY - 2010 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1389 AB - In this paper, the definition of simvastatin degradation profile by microemulsion liquid chromatography (MELC) is presented. The aim of the study was to investigate simvastatin stability after various stress tests, such as: acid and base hydrolysis, oxidation, and heat. The kinetics of acid and oxidative degradation was also studied. The complex retention mechanism occurring when microemulsion is used as eluent enabled the successful separation of a large number of degradants in prepared stress samples. The existence of a second partitioning site due to microstructural and interfacial characteristics of o/w microemulsion eluent facilitated HPLC separation. All the expected capabilities of MELC method were realized, demonstrating the advantage and value of the MELC method for a wide area of pharmaceutical analysis. For acid degradation the second order rate constant and half-life were calculated. Oxidative decomposition proved to be the first order reaction for which the rate constant and half-life were also determined. PB - Taylor & Francis Inc, Philadelphia T2 - Journal of Liquid Chromatography & Related Technologies T1 - Forced degradation studies of simvastatin using microemulsion liquid chromatography VL - 33 IS - 4 SP - 536 EP - 547 DO - 10.1080/10826070903574576 ER -
@article{ author = "Malenović, Anđelija and Jančić-Stojanović, Biljana and Ivanović, Darko and Medenica, Mirjana", year = "2010", abstract = "In this paper, the definition of simvastatin degradation profile by microemulsion liquid chromatography (MELC) is presented. The aim of the study was to investigate simvastatin stability after various stress tests, such as: acid and base hydrolysis, oxidation, and heat. The kinetics of acid and oxidative degradation was also studied. The complex retention mechanism occurring when microemulsion is used as eluent enabled the successful separation of a large number of degradants in prepared stress samples. The existence of a second partitioning site due to microstructural and interfacial characteristics of o/w microemulsion eluent facilitated HPLC separation. All the expected capabilities of MELC method were realized, demonstrating the advantage and value of the MELC method for a wide area of pharmaceutical analysis. For acid degradation the second order rate constant and half-life were calculated. Oxidative decomposition proved to be the first order reaction for which the rate constant and half-life were also determined.", publisher = "Taylor & Francis Inc, Philadelphia", journal = "Journal of Liquid Chromatography & Related Technologies", title = "Forced degradation studies of simvastatin using microemulsion liquid chromatography", volume = "33", number = "4", pages = "536-547", doi = "10.1080/10826070903574576" }
Malenović, A., Jančić-Stojanović, B., Ivanović, D.,& Medenica, M.. (2010). Forced degradation studies of simvastatin using microemulsion liquid chromatography. in Journal of Liquid Chromatography & Related Technologies Taylor & Francis Inc, Philadelphia., 33(4), 536-547. https://doi.org/10.1080/10826070903574576
Malenović A, Jančić-Stojanović B, Ivanović D, Medenica M. Forced degradation studies of simvastatin using microemulsion liquid chromatography. in Journal of Liquid Chromatography & Related Technologies. 2010;33(4):536-547. doi:10.1080/10826070903574576 .
Malenović, Anđelija, Jančić-Stojanović, Biljana, Ivanović, Darko, Medenica, Mirjana, "Forced degradation studies of simvastatin using microemulsion liquid chromatography" in Journal of Liquid Chromatography & Related Technologies, 33, no. 4 (2010):536-547, https://doi.org/10.1080/10826070903574576 . .