Cadmium toxicity revisited: Focus on oxidative stress induction and interactions with zinc and magnesium
Abstract
Discovered in late 1817, Cadmium is currently one of the most important occupational and environmental pollutants. It is associated with renal, neurological, skeletal and other toxic effects, including reproductive toxicity, genotoxicity, and carcinogenicity. There is still much to find out about its mechanisms of action, biomarkers of critical effects, and ways to reduce health risks. At present, there is no clinically efficient agent to treat cadmium poisoning due to predominantly intracellular location of cadmium ions. This article gives a brief review of cadmium-induced oxidative stress and its interactions with essential elements zinc and magnesium as relevant mechanisms of cadmium toxicity. It draws on available literature data and our own results, which indicate that dietary supplementation of either essential element has beneficial effect under condition of cadmium. exposure. We have also tackled the reasons why magnesium addition prevails over zinc and discussed the protective... role of magnesium during cadmium exposure. These findings could help to solve the problem of prophylaxis and therapy of increased cadmium body burden.
Keywords:
carcinogenicity chelation therapy / dietary supplementation / essential elementsSource:
Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 2011, 62, 1, 65-76Publisher:
- Inst Medical Research & Occupational Health, Zagreb
Funding / projects:
DOI: 10.2478/10004-1254-62-2011-2075
ISSN: 0004-1254
PubMed: 21421535
WoS: 000288884000009
Scopus: 2-s2.0-79953062331
Collections
Institution/Community
PharmacyTY - JOUR AU - Matović, Vesna AU - Buha, Aleksandra AU - Bulat, Zorica AU - Đukić-Ćosić, Danijela PY - 2011 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1451 AB - Discovered in late 1817, Cadmium is currently one of the most important occupational and environmental pollutants. It is associated with renal, neurological, skeletal and other toxic effects, including reproductive toxicity, genotoxicity, and carcinogenicity. There is still much to find out about its mechanisms of action, biomarkers of critical effects, and ways to reduce health risks. At present, there is no clinically efficient agent to treat cadmium poisoning due to predominantly intracellular location of cadmium ions. This article gives a brief review of cadmium-induced oxidative stress and its interactions with essential elements zinc and magnesium as relevant mechanisms of cadmium toxicity. It draws on available literature data and our own results, which indicate that dietary supplementation of either essential element has beneficial effect under condition of cadmium. exposure. We have also tackled the reasons why magnesium addition prevails over zinc and discussed the protective role of magnesium during cadmium exposure. These findings could help to solve the problem of prophylaxis and therapy of increased cadmium body burden. PB - Inst Medical Research & Occupational Health, Zagreb T2 - Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology T1 - Cadmium toxicity revisited: Focus on oxidative stress induction and interactions with zinc and magnesium VL - 62 IS - 1 SP - 65 EP - 76 DO - 10.2478/10004-1254-62-2011-2075 ER -
@article{ author = "Matović, Vesna and Buha, Aleksandra and Bulat, Zorica and Đukić-Ćosić, Danijela", year = "2011", abstract = "Discovered in late 1817, Cadmium is currently one of the most important occupational and environmental pollutants. It is associated with renal, neurological, skeletal and other toxic effects, including reproductive toxicity, genotoxicity, and carcinogenicity. There is still much to find out about its mechanisms of action, biomarkers of critical effects, and ways to reduce health risks. At present, there is no clinically efficient agent to treat cadmium poisoning due to predominantly intracellular location of cadmium ions. This article gives a brief review of cadmium-induced oxidative stress and its interactions with essential elements zinc and magnesium as relevant mechanisms of cadmium toxicity. It draws on available literature data and our own results, which indicate that dietary supplementation of either essential element has beneficial effect under condition of cadmium. exposure. We have also tackled the reasons why magnesium addition prevails over zinc and discussed the protective role of magnesium during cadmium exposure. These findings could help to solve the problem of prophylaxis and therapy of increased cadmium body burden.", publisher = "Inst Medical Research & Occupational Health, Zagreb", journal = "Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology", title = "Cadmium toxicity revisited: Focus on oxidative stress induction and interactions with zinc and magnesium", volume = "62", number = "1", pages = "65-76", doi = "10.2478/10004-1254-62-2011-2075" }
Matović, V., Buha, A., Bulat, Z.,& Đukić-Ćosić, D.. (2011). Cadmium toxicity revisited: Focus on oxidative stress induction and interactions with zinc and magnesium. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology Inst Medical Research & Occupational Health, Zagreb., 62(1), 65-76. https://doi.org/10.2478/10004-1254-62-2011-2075
Matović V, Buha A, Bulat Z, Đukić-Ćosić D. Cadmium toxicity revisited: Focus on oxidative stress induction and interactions with zinc and magnesium. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology. 2011;62(1):65-76. doi:10.2478/10004-1254-62-2011-2075 .
Matović, Vesna, Buha, Aleksandra, Bulat, Zorica, Đukić-Ćosić, Danijela, "Cadmium toxicity revisited: Focus on oxidative stress induction and interactions with zinc and magnesium" in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 62, no. 1 (2011):65-76, https://doi.org/10.2478/10004-1254-62-2011-2075 . .