Study of the Influence of Primary Packaging on Photostability of Tablets Containing Carvedilol
Apstrakt
The aim of this work was to select an appropriate primary packaging and analysis of its influence on stability, of tablets containing Carvedilol (Karvileks, Zdravlje-Actavis, Serbia). The influence of different primary packaging materials and doses radiation was investigated. Karvileks tablets were put in an opaque plastic container, red and white blister packs, composed of polyvinyl chloride and aluminum foil (PVC/Al). After radiation, the content was estimated using a validated HPLC method. Tablets, packaged in different primary packaging materials, were exposed at different doses of UV and VIS radiation. In case of blister packs, the content of active substance was lower than 85% compared with an initial content. Tablets packaged in the opaque plastic containers, the content of carvedilol was not lower than 90%, after radiation. The study showed that the opaque plastic containers provide better photo protection than red and white blister packs for solid oral dosage forms of Karvilek...s.
Ključne reči:
Karvileks / photostability / HPLC / packaging / tabletsIzvor:
Indian Journal of Pharmaceutical Education and Research, 2011, 45, 4, 353-359Izdavač:
- Assoc Pharmaceutical Teachers India, Bangalore
Finansiranje / projekti:
- Biljni i sintetički bioaktivni proizvodi novije generacije (RS-MESTD-Technological Development (TD or TR)-34012)
Institucija/grupa
PharmacyTY - JOUR AU - Savić, Ivan AU - Marinković, Valentina AU - Savić, Ivana AU - Sibinović, Predrag PY - 2011 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1498 AB - The aim of this work was to select an appropriate primary packaging and analysis of its influence on stability, of tablets containing Carvedilol (Karvileks, Zdravlje-Actavis, Serbia). The influence of different primary packaging materials and doses radiation was investigated. Karvileks tablets were put in an opaque plastic container, red and white blister packs, composed of polyvinyl chloride and aluminum foil (PVC/Al). After radiation, the content was estimated using a validated HPLC method. Tablets, packaged in different primary packaging materials, were exposed at different doses of UV and VIS radiation. In case of blister packs, the content of active substance was lower than 85% compared with an initial content. Tablets packaged in the opaque plastic containers, the content of carvedilol was not lower than 90%, after radiation. The study showed that the opaque plastic containers provide better photo protection than red and white blister packs for solid oral dosage forms of Karvileks. PB - Assoc Pharmaceutical Teachers India, Bangalore T2 - Indian Journal of Pharmaceutical Education and Research T1 - Study of the Influence of Primary Packaging on Photostability of Tablets Containing Carvedilol VL - 45 IS - 4 SP - 353 EP - 359 UR - https://hdl.handle.net/21.15107/rcub_farfar_1498 ER -
@article{ author = "Savić, Ivan and Marinković, Valentina and Savić, Ivana and Sibinović, Predrag", year = "2011", abstract = "The aim of this work was to select an appropriate primary packaging and analysis of its influence on stability, of tablets containing Carvedilol (Karvileks, Zdravlje-Actavis, Serbia). The influence of different primary packaging materials and doses radiation was investigated. Karvileks tablets were put in an opaque plastic container, red and white blister packs, composed of polyvinyl chloride and aluminum foil (PVC/Al). After radiation, the content was estimated using a validated HPLC method. Tablets, packaged in different primary packaging materials, were exposed at different doses of UV and VIS radiation. In case of blister packs, the content of active substance was lower than 85% compared with an initial content. Tablets packaged in the opaque plastic containers, the content of carvedilol was not lower than 90%, after radiation. The study showed that the opaque plastic containers provide better photo protection than red and white blister packs for solid oral dosage forms of Karvileks.", publisher = "Assoc Pharmaceutical Teachers India, Bangalore", journal = "Indian Journal of Pharmaceutical Education and Research", title = "Study of the Influence of Primary Packaging on Photostability of Tablets Containing Carvedilol", volume = "45", number = "4", pages = "353-359", url = "https://hdl.handle.net/21.15107/rcub_farfar_1498" }
Savić, I., Marinković, V., Savić, I.,& Sibinović, P.. (2011). Study of the Influence of Primary Packaging on Photostability of Tablets Containing Carvedilol. in Indian Journal of Pharmaceutical Education and Research Assoc Pharmaceutical Teachers India, Bangalore., 45(4), 353-359. https://hdl.handle.net/21.15107/rcub_farfar_1498
Savić I, Marinković V, Savić I, Sibinović P. Study of the Influence of Primary Packaging on Photostability of Tablets Containing Carvedilol. in Indian Journal of Pharmaceutical Education and Research. 2011;45(4):353-359. https://hdl.handle.net/21.15107/rcub_farfar_1498 .
Savić, Ivan, Marinković, Valentina, Savić, Ivana, Sibinović, Predrag, "Study of the Influence of Primary Packaging on Photostability of Tablets Containing Carvedilol" in Indian Journal of Pharmaceutical Education and Research, 45, no. 4 (2011):353-359, https://hdl.handle.net/21.15107/rcub_farfar_1498 .