Evaluation of the compression behavior of paracetamol tablets produced by dispersion in beta-cyclodextrin .1. Scanning electron microscopic study of tablets
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1997
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The compression behaviour of three powder products of Paracetamol-beta-cyclodextrin solid dispersions (PAR-beta-CD SD) and PAR alone were evaluated using the method of scanning electron microscopy (SEM). The four powder products were: PAR, PAR-beta-CD physical mixture, kneaded solid dispersion of PAR-beta-CD and spray dried solid dispersion of PAR-beta-CD (PAR-beta-CD ratio of 1:1 w/w). By observing the surface, side and broken surface of each tablet sample under different magnifications the compression behaviour, mechanism of consolidation and deformability of particles were evaluated. PAR alone and the PAR-beta-CD physical mixture were compressed by the brittle fracture mechanism; the PAR-beta-CD kneaded solid dispersion showed a good plastical deformation. With PAR-beta-CD spray dried solid dispersion a good plastic deformation and mechanism of cool sintering were postulated. The influence of beta-CD on the compression behavior of the PAR was proved. The results obtained by the SEM ...method are well correlated with physicopharmaceutical parameters (crushing strength, disintegration time, friability, elastic recovery and tensile strength) of the tablets.
Izvor:
Journal of Inclusion Phenomena and Molecular Recognition in Chemistry, 1997, 28, 4, 299-314Izdavač:
- Kluwer Academic Publ, Dordrecht
DOI: 10.1023/A:1007924212334
ISSN: 0923-0750
WoS: A1997XQ28100003
Scopus: 2-s2.0-0031206583
Institucija/grupa
PharmacyTY - JOUR AU - Tasić, Ljiljana AU - PintyeHodi, K AU - SzaboRevesz, P PY - 1997 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/150 AB - The compression behaviour of three powder products of Paracetamol-beta-cyclodextrin solid dispersions (PAR-beta-CD SD) and PAR alone were evaluated using the method of scanning electron microscopy (SEM). The four powder products were: PAR, PAR-beta-CD physical mixture, kneaded solid dispersion of PAR-beta-CD and spray dried solid dispersion of PAR-beta-CD (PAR-beta-CD ratio of 1:1 w/w). By observing the surface, side and broken surface of each tablet sample under different magnifications the compression behaviour, mechanism of consolidation and deformability of particles were evaluated. PAR alone and the PAR-beta-CD physical mixture were compressed by the brittle fracture mechanism; the PAR-beta-CD kneaded solid dispersion showed a good plastical deformation. With PAR-beta-CD spray dried solid dispersion a good plastic deformation and mechanism of cool sintering were postulated. The influence of beta-CD on the compression behavior of the PAR was proved. The results obtained by the SEM method are well correlated with physicopharmaceutical parameters (crushing strength, disintegration time, friability, elastic recovery and tensile strength) of the tablets. PB - Kluwer Academic Publ, Dordrecht T2 - Journal of Inclusion Phenomena and Molecular Recognition in Chemistry T1 - Evaluation of the compression behavior of paracetamol tablets produced by dispersion in beta-cyclodextrin .1. Scanning electron microscopic study of tablets VL - 28 IS - 4 SP - 299 EP - 314 DO - 10.1023/A:1007924212334 ER -
@article{ author = "Tasić, Ljiljana and PintyeHodi, K and SzaboRevesz, P", year = "1997", abstract = "The compression behaviour of three powder products of Paracetamol-beta-cyclodextrin solid dispersions (PAR-beta-CD SD) and PAR alone were evaluated using the method of scanning electron microscopy (SEM). The four powder products were: PAR, PAR-beta-CD physical mixture, kneaded solid dispersion of PAR-beta-CD and spray dried solid dispersion of PAR-beta-CD (PAR-beta-CD ratio of 1:1 w/w). By observing the surface, side and broken surface of each tablet sample under different magnifications the compression behaviour, mechanism of consolidation and deformability of particles were evaluated. PAR alone and the PAR-beta-CD physical mixture were compressed by the brittle fracture mechanism; the PAR-beta-CD kneaded solid dispersion showed a good plastical deformation. With PAR-beta-CD spray dried solid dispersion a good plastic deformation and mechanism of cool sintering were postulated. The influence of beta-CD on the compression behavior of the PAR was proved. The results obtained by the SEM method are well correlated with physicopharmaceutical parameters (crushing strength, disintegration time, friability, elastic recovery and tensile strength) of the tablets.", publisher = "Kluwer Academic Publ, Dordrecht", journal = "Journal of Inclusion Phenomena and Molecular Recognition in Chemistry", title = "Evaluation of the compression behavior of paracetamol tablets produced by dispersion in beta-cyclodextrin .1. Scanning electron microscopic study of tablets", volume = "28", number = "4", pages = "299-314", doi = "10.1023/A:1007924212334" }
Tasić, L., PintyeHodi, K.,& SzaboRevesz, P.. (1997). Evaluation of the compression behavior of paracetamol tablets produced by dispersion in beta-cyclodextrin .1. Scanning electron microscopic study of tablets. in Journal of Inclusion Phenomena and Molecular Recognition in Chemistry Kluwer Academic Publ, Dordrecht., 28(4), 299-314. https://doi.org/10.1023/A:1007924212334
Tasić L, PintyeHodi K, SzaboRevesz P. Evaluation of the compression behavior of paracetamol tablets produced by dispersion in beta-cyclodextrin .1. Scanning electron microscopic study of tablets. in Journal of Inclusion Phenomena and Molecular Recognition in Chemistry. 1997;28(4):299-314. doi:10.1023/A:1007924212334 .
Tasić, Ljiljana, PintyeHodi, K, SzaboRevesz, P, "Evaluation of the compression behavior of paracetamol tablets produced by dispersion in beta-cyclodextrin .1. Scanning electron microscopic study of tablets" in Journal of Inclusion Phenomena and Molecular Recognition in Chemistry, 28, no. 4 (1997):299-314, https://doi.org/10.1023/A:1007924212334 . .