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Investigation of Solvolysis Kinetics of New Synthesized Fluocinolone Acetonide C-21 Esters-An In Vitro Model for Prodrug Activation
dc.creator | Marković, Bojan | |
dc.creator | Dobričić, Vladimir | |
dc.creator | Vladimirov, Sote | |
dc.creator | Čudina, Olivera | |
dc.creator | Savić, Vladimir | |
dc.creator | Karljiković-Rajić, Katarina | |
dc.date.accessioned | 2019-09-02T11:24:35Z | |
dc.date.available | 2019-09-02T11:24:35Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1420-3049 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1524 | |
dc.description.abstract | In this study the solvolysis of newly synthesized fluocinolone acetonide C-21 esters was analysed in comparison with fluocinonide during a 24-hour period of time. The solvolysis was performed in an ethanol-water (90:10 v/v) mixture using the excess of NaHCO(3). The solvolytic mixtures of each investigated ester have been assayed by a RP-HPLC method using isocratic elution with methanol-water (75:25 v/v); flow rate 1 mL/min; detection at 238 nm; temperature 25 degrees C. Solvolytic rate constants were calculated from the obtained data. Geometry optimizations and charges calculations were carried out by Gaussian W03 software. A good correlation (R = 0.9924) was obtained between solvolytic rate constants and the polarity of the C-O2 bond of those esters. The established relation between solvolytic rate constant (K) and lipophilicity (cLogP) with experimental anti-inflammatory activity could be indicative for topical corticosteroid prodrug activation. | en |
dc.publisher | MDPI, Basel | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172041/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Molecules | |
dc.subject | prodrug | en |
dc.subject | fluocinolone acetonide esters | en |
dc.subject | solvolysis | en |
dc.subject | descriptor | en |
dc.subject | in vitro model | en |
dc.title | Investigation of Solvolysis Kinetics of New Synthesized Fluocinolone Acetonide C-21 Esters-An In Vitro Model for Prodrug Activation | en |
dc.type | article | |
dc.rights.license | BY | |
dcterms.abstract | Чудина, Оливера; Добричић, Владимир; Владимиров, Соте; Марковић, Бојан; Карљиковић-Рајић, Катарина; Савић, Владимир; | |
dc.citation.volume | 16 | |
dc.citation.issue | 3 | |
dc.citation.spage | 2658 | |
dc.citation.epage | 2671 | |
dc.citation.other | 16(3): 2658-2671 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000288853400053 | |
dc.identifier.doi | 10.3390/molecules16032658 | |
dc.identifier.pmid | 21441868 | |
dc.identifier.scopus | 2-s2.0-79953090073 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/383/1522.pdf | |
dc.type.version | publishedVersion |