Gender-Specific Oxidative Stress Parameters
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2011
Authors
Dopsaj, VioletaMartinović, J.
Dopsaj, Milivoj
Kotur-Stevuljević, Jelena
Bogavac-Stanojević, Nataša
Article (Published version)
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The aim of the present study was to examine the association of proteins that regulate iron transport/storage content and acute phase response with oxidative stress in male and female athletes. Serum ferritin, transferrin, soluble transferrin receptor, C-reactive protein, interleukin-6 and oxidative stress parameters (reactive oxygen metabolites, superoxide anion, advanced oxidation protein products, lipid hydroperoxides, superoxide-dismutase and pro-oxidant-antioxidant balance) were determined in 138 athletes (73 females and 65 males). A general linear model indicated significant gender differences between athletes in terms of reactive oxygen metabolites (307.48 +/- 61.02 vs. 276.98 +/- 50.08; P = 0.030), superoxide-dismutase (114.60 +/- 41.64 vs. 101.42 +/- 38.76; P = 0.001), lipid hydroperoxides (149.84 +/- 38.95 vs. 101.43 +/- 39.26; P lt 0.001), pro-oxidant-antioxidant balance (512.40 +/- 148.67 vs. 413.09 +/- 120.30; P = 0.002), advanced oxidation protein products (1.49 +/- 0.30... vs. 0.91 +/- 0.25; P lt 0.001) and superoxide (2.61 +/- 0.36 vs. 2.22 +/- 0.35; P = 0.001), which were all significantly higher in females. Multivariate analysis of covariance indicated gender (P lt 0.001), training experience (P = 0.004), Creactive protein (P = 0.002), soluble transferrin receptor (P = 0.004) and transferrin (P lt 0.001) as significant covariates. Gender accounted for the largest proportion of variability for all oxidative stress parameters (46.3%) and female athletes were more susceptible to oxidative stress. Iron transport and storage proteins (transferrin and ferritin), but also acute phase reactants, were negatively related factors for oxidative stress. In conclusion, variation in the ferritin level may contribute to the different oxidative stress level between the sexes.
Keywords:
free radicals / ferritin / transferrin / acute phase response / superoxide-dismutaseSource:
International Journal of Sports Medicine, 2011, 32, 1, 14-19Publisher:
- Georg Thieme Verlag Kg, Stuttgart
Funding / projects:
- Ispitivanje biohemijskih i genetičkih faktora rizika kao uzročnika i markera ateroskleroze i drugih oboljenja: analitički i klinički aspekti (RS-MESTD-MPN2006-2010-145036)
DOI: 10.1055/s-0030-1267930
ISSN: 0172-4622
PubMed: 21086243
WoS: 000286657900003
Scopus: 2-s2.0-79551509743
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Institution/Community
PharmacyTY - JOUR AU - Dopsaj, Violeta AU - Martinović, J. AU - Dopsaj, Milivoj AU - Kotur-Stevuljević, Jelena AU - Bogavac-Stanojević, Nataša PY - 2011 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1539 AB - The aim of the present study was to examine the association of proteins that regulate iron transport/storage content and acute phase response with oxidative stress in male and female athletes. Serum ferritin, transferrin, soluble transferrin receptor, C-reactive protein, interleukin-6 and oxidative stress parameters (reactive oxygen metabolites, superoxide anion, advanced oxidation protein products, lipid hydroperoxides, superoxide-dismutase and pro-oxidant-antioxidant balance) were determined in 138 athletes (73 females and 65 males). A general linear model indicated significant gender differences between athletes in terms of reactive oxygen metabolites (307.48 +/- 61.02 vs. 276.98 +/- 50.08; P = 0.030), superoxide-dismutase (114.60 +/- 41.64 vs. 101.42 +/- 38.76; P = 0.001), lipid hydroperoxides (149.84 +/- 38.95 vs. 101.43 +/- 39.26; P lt 0.001), pro-oxidant-antioxidant balance (512.40 +/- 148.67 vs. 413.09 +/- 120.30; P = 0.002), advanced oxidation protein products (1.49 +/- 0.30 vs. 0.91 +/- 0.25; P lt 0.001) and superoxide (2.61 +/- 0.36 vs. 2.22 +/- 0.35; P = 0.001), which were all significantly higher in females. Multivariate analysis of covariance indicated gender (P lt 0.001), training experience (P = 0.004), Creactive protein (P = 0.002), soluble transferrin receptor (P = 0.004) and transferrin (P lt 0.001) as significant covariates. Gender accounted for the largest proportion of variability for all oxidative stress parameters (46.3%) and female athletes were more susceptible to oxidative stress. Iron transport and storage proteins (transferrin and ferritin), but also acute phase reactants, were negatively related factors for oxidative stress. In conclusion, variation in the ferritin level may contribute to the different oxidative stress level between the sexes. PB - Georg Thieme Verlag Kg, Stuttgart T2 - International Journal of Sports Medicine T1 - Gender-Specific Oxidative Stress Parameters VL - 32 IS - 1 SP - 14 EP - 19 DO - 10.1055/s-0030-1267930 ER -
@article{ author = "Dopsaj, Violeta and Martinović, J. and Dopsaj, Milivoj and Kotur-Stevuljević, Jelena and Bogavac-Stanojević, Nataša", year = "2011", abstract = "The aim of the present study was to examine the association of proteins that regulate iron transport/storage content and acute phase response with oxidative stress in male and female athletes. Serum ferritin, transferrin, soluble transferrin receptor, C-reactive protein, interleukin-6 and oxidative stress parameters (reactive oxygen metabolites, superoxide anion, advanced oxidation protein products, lipid hydroperoxides, superoxide-dismutase and pro-oxidant-antioxidant balance) were determined in 138 athletes (73 females and 65 males). A general linear model indicated significant gender differences between athletes in terms of reactive oxygen metabolites (307.48 +/- 61.02 vs. 276.98 +/- 50.08; P = 0.030), superoxide-dismutase (114.60 +/- 41.64 vs. 101.42 +/- 38.76; P = 0.001), lipid hydroperoxides (149.84 +/- 38.95 vs. 101.43 +/- 39.26; P lt 0.001), pro-oxidant-antioxidant balance (512.40 +/- 148.67 vs. 413.09 +/- 120.30; P = 0.002), advanced oxidation protein products (1.49 +/- 0.30 vs. 0.91 +/- 0.25; P lt 0.001) and superoxide (2.61 +/- 0.36 vs. 2.22 +/- 0.35; P = 0.001), which were all significantly higher in females. Multivariate analysis of covariance indicated gender (P lt 0.001), training experience (P = 0.004), Creactive protein (P = 0.002), soluble transferrin receptor (P = 0.004) and transferrin (P lt 0.001) as significant covariates. Gender accounted for the largest proportion of variability for all oxidative stress parameters (46.3%) and female athletes were more susceptible to oxidative stress. Iron transport and storage proteins (transferrin and ferritin), but also acute phase reactants, were negatively related factors for oxidative stress. In conclusion, variation in the ferritin level may contribute to the different oxidative stress level between the sexes.", publisher = "Georg Thieme Verlag Kg, Stuttgart", journal = "International Journal of Sports Medicine", title = "Gender-Specific Oxidative Stress Parameters", volume = "32", number = "1", pages = "14-19", doi = "10.1055/s-0030-1267930" }
Dopsaj, V., Martinović, J., Dopsaj, M., Kotur-Stevuljević, J.,& Bogavac-Stanojević, N.. (2011). Gender-Specific Oxidative Stress Parameters. in International Journal of Sports Medicine Georg Thieme Verlag Kg, Stuttgart., 32(1), 14-19. https://doi.org/10.1055/s-0030-1267930
Dopsaj V, Martinović J, Dopsaj M, Kotur-Stevuljević J, Bogavac-Stanojević N. Gender-Specific Oxidative Stress Parameters. in International Journal of Sports Medicine. 2011;32(1):14-19. doi:10.1055/s-0030-1267930 .
Dopsaj, Violeta, Martinović, J., Dopsaj, Milivoj, Kotur-Stevuljević, Jelena, Bogavac-Stanojević, Nataša, "Gender-Specific Oxidative Stress Parameters" in International Journal of Sports Medicine, 32, no. 1 (2011):14-19, https://doi.org/10.1055/s-0030-1267930 . .