An investigation of formulation factors affecting feasibility of alginate-chitosan microparticles for oral delivery of naproxen
Samo za registrovane korisnike
2011
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
In the present work we investigated the feasibility of chitosan treated Ca-alginate microparticles for delivery of naproxen in lower parts of GIT and evaluated influence of formulation factors on their physicochemical characteristics and drug release profiles. Investigated factors were drug/polymer ratio, chitosan molecular weight, chitosan concentration in hardening medium, and hardening time. Sixteen microparticle formulations were prepared utilizing 24 full factorial design (each factor was varied at two levels). Microparticles size varied between 262.3 +/- 14.9 and 358.4 +/- 21.7 mu m with slightly deformed spherical shape. Low naproxen solubility and rapid reaction of ionotropic gelation resulted in high encapsulation efficiency (> 75.19%). Under conditions mimicking those in the stomach, after two hours, less than 6.18% of naproxen was released. Significant influence of all investigated factors on drug release rate was observed in simulated small intestinal fluid. Furthermore, ex...perimental design analysis revealed that chitosan molecular weight and its concentration had the most pronounced effect on naproxen release. Release data kinetics indicated predominant influence of a pH-dependent relaxation mechanism on drug release from microparticles.
Ključne reči:
Naproxen / Alginate-chitosan microparticles / Experimental design / Sustained releaseIzvor:
Archives of Pharmacal Research, 2011, 34, 6, 919-929Izdavač:
- Pharmaceutical Soc Korea, Seoul
Finansiranje / projekti:
- Razvoj i karakterizacija koloidnih nosača za antiinflamatorne lekove (RS-MESTD-MPN2006-2010-19058)
DOI: 10.1007/s12272-011-0609-y
ISSN: 0253-6269
PubMed: 21725813
WoS: 000292306000011
Scopus: 2-s2.0-79960227585
Institucija/grupa
PharmacyTY - JOUR AU - Čalija, Bojan AU - Cekić, Nebojša AU - Savić, Snežana AU - Krajišnik, Danina AU - Daniels, Rolf AU - Milić, Jela PY - 2011 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1558 AB - In the present work we investigated the feasibility of chitosan treated Ca-alginate microparticles for delivery of naproxen in lower parts of GIT and evaluated influence of formulation factors on their physicochemical characteristics and drug release profiles. Investigated factors were drug/polymer ratio, chitosan molecular weight, chitosan concentration in hardening medium, and hardening time. Sixteen microparticle formulations were prepared utilizing 24 full factorial design (each factor was varied at two levels). Microparticles size varied between 262.3 +/- 14.9 and 358.4 +/- 21.7 mu m with slightly deformed spherical shape. Low naproxen solubility and rapid reaction of ionotropic gelation resulted in high encapsulation efficiency (> 75.19%). Under conditions mimicking those in the stomach, after two hours, less than 6.18% of naproxen was released. Significant influence of all investigated factors on drug release rate was observed in simulated small intestinal fluid. Furthermore, experimental design analysis revealed that chitosan molecular weight and its concentration had the most pronounced effect on naproxen release. Release data kinetics indicated predominant influence of a pH-dependent relaxation mechanism on drug release from microparticles. PB - Pharmaceutical Soc Korea, Seoul T2 - Archives of Pharmacal Research T1 - An investigation of formulation factors affecting feasibility of alginate-chitosan microparticles for oral delivery of naproxen VL - 34 IS - 6 SP - 919 EP - 929 DO - 10.1007/s12272-011-0609-y ER -
@article{ author = "Čalija, Bojan and Cekić, Nebojša and Savić, Snežana and Krajišnik, Danina and Daniels, Rolf and Milić, Jela", year = "2011", abstract = "In the present work we investigated the feasibility of chitosan treated Ca-alginate microparticles for delivery of naproxen in lower parts of GIT and evaluated influence of formulation factors on their physicochemical characteristics and drug release profiles. Investigated factors were drug/polymer ratio, chitosan molecular weight, chitosan concentration in hardening medium, and hardening time. Sixteen microparticle formulations were prepared utilizing 24 full factorial design (each factor was varied at two levels). Microparticles size varied between 262.3 +/- 14.9 and 358.4 +/- 21.7 mu m with slightly deformed spherical shape. Low naproxen solubility and rapid reaction of ionotropic gelation resulted in high encapsulation efficiency (> 75.19%). Under conditions mimicking those in the stomach, after two hours, less than 6.18% of naproxen was released. Significant influence of all investigated factors on drug release rate was observed in simulated small intestinal fluid. Furthermore, experimental design analysis revealed that chitosan molecular weight and its concentration had the most pronounced effect on naproxen release. Release data kinetics indicated predominant influence of a pH-dependent relaxation mechanism on drug release from microparticles.", publisher = "Pharmaceutical Soc Korea, Seoul", journal = "Archives of Pharmacal Research", title = "An investigation of formulation factors affecting feasibility of alginate-chitosan microparticles for oral delivery of naproxen", volume = "34", number = "6", pages = "919-929", doi = "10.1007/s12272-011-0609-y" }
Čalija, B., Cekić, N., Savić, S., Krajišnik, D., Daniels, R.,& Milić, J.. (2011). An investigation of formulation factors affecting feasibility of alginate-chitosan microparticles for oral delivery of naproxen. in Archives of Pharmacal Research Pharmaceutical Soc Korea, Seoul., 34(6), 919-929. https://doi.org/10.1007/s12272-011-0609-y
Čalija B, Cekić N, Savić S, Krajišnik D, Daniels R, Milić J. An investigation of formulation factors affecting feasibility of alginate-chitosan microparticles for oral delivery of naproxen. in Archives of Pharmacal Research. 2011;34(6):919-929. doi:10.1007/s12272-011-0609-y .
Čalija, Bojan, Cekić, Nebojša, Savić, Snežana, Krajišnik, Danina, Daniels, Rolf, Milić, Jela, "An investigation of formulation factors affecting feasibility of alginate-chitosan microparticles for oral delivery of naproxen" in Archives of Pharmacal Research, 34, no. 6 (2011):919-929, https://doi.org/10.1007/s12272-011-0609-y . .