Route-dependent effects of cadmium/cadmium and magnesium acute treatment on parameters of oxidative stress in rat liver
Samo za registrovane korisnike
2012
Autori
Matović, VesnaBuha, Aleksandra
Bulat, Zorica
Đukić-Ćosić, Danijela
Miljković, Milica
Ivanišević, Jasmina
Kotur-Stevuljević, Jelena
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The study was designed to evaluate and compare the effects of single oral (or) and intraperitoneal (i.p.) cadmium (Cd) administration on parameters of oxidative stress in liver of rats. Furthermore, investigation on protective effects of magnesium (Mg) or and i.p. pretreatment on the same parameters was performed. Wistar rats were administrated oral dose of Cd (30 mg Cd/kg b.w.)/Cd + Mg (30 mg Cd/kg b.w., 50 mg Mg/kg b.w.) or i.p. dose of Cd (1.5 mg Cd/kg b.w.)/Cd + Mg (1.5 mg Cd/kg b.w., 3 mg Mg/kg b.w.) and sacrificed after 24 h. In liver homogenates superoxide anion, malondialdehyde, non-protein sulfhydryl groups, total sulfhydryl groups content, and superoxide dismutase activity were determined. Cadmium intoxication caused the increase of superoxide anion and malondialdehyde levels and had negative effect on investigated parameters of antioxidant defense system, except on total sulfhydryl groups. The negative effect was more emphasized after i.p. Cd administration. Oral Mg pretreat...ment induced more pronounced positive effect than Mg given intraperitoneally that can be attributed, at least partly, to Cd and Mg interactions on the level of GIT. On the basis of the obtained results it can be concluded that both Cd and Cd + Mg effects on parameters of oxidative stress in rats liver are route-dependent.
Ključne reči:
Cadmium / Magnesium / Oxidative stress / Oral / Intraperitoneal / RatsIzvor:
Food and Chemical Toxicology, 2012, 50, 3-4, 552-557Izdavač:
- Pergamon-Elsevier Science Ltd, Oxford
Finansiranje / projekti:
DOI: 10.1016/j.fct.2011.12.035
ISSN: 0278-6915
PubMed: 22240416
WoS: 000303284600016
Scopus: 2-s2.0-84857932466
Institucija/grupa
PharmacyTY - JOUR AU - Matović, Vesna AU - Buha, Aleksandra AU - Bulat, Zorica AU - Đukić-Ćosić, Danijela AU - Miljković, Milica AU - Ivanišević, Jasmina AU - Kotur-Stevuljević, Jelena PY - 2012 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1761 AB - The study was designed to evaluate and compare the effects of single oral (or) and intraperitoneal (i.p.) cadmium (Cd) administration on parameters of oxidative stress in liver of rats. Furthermore, investigation on protective effects of magnesium (Mg) or and i.p. pretreatment on the same parameters was performed. Wistar rats were administrated oral dose of Cd (30 mg Cd/kg b.w.)/Cd + Mg (30 mg Cd/kg b.w., 50 mg Mg/kg b.w.) or i.p. dose of Cd (1.5 mg Cd/kg b.w.)/Cd + Mg (1.5 mg Cd/kg b.w., 3 mg Mg/kg b.w.) and sacrificed after 24 h. In liver homogenates superoxide anion, malondialdehyde, non-protein sulfhydryl groups, total sulfhydryl groups content, and superoxide dismutase activity were determined. Cadmium intoxication caused the increase of superoxide anion and malondialdehyde levels and had negative effect on investigated parameters of antioxidant defense system, except on total sulfhydryl groups. The negative effect was more emphasized after i.p. Cd administration. Oral Mg pretreatment induced more pronounced positive effect than Mg given intraperitoneally that can be attributed, at least partly, to Cd and Mg interactions on the level of GIT. On the basis of the obtained results it can be concluded that both Cd and Cd + Mg effects on parameters of oxidative stress in rats liver are route-dependent. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Food and Chemical Toxicology T1 - Route-dependent effects of cadmium/cadmium and magnesium acute treatment on parameters of oxidative stress in rat liver VL - 50 IS - 3-4 SP - 552 EP - 557 DO - 10.1016/j.fct.2011.12.035 ER -
@article{ author = "Matović, Vesna and Buha, Aleksandra and Bulat, Zorica and Đukić-Ćosić, Danijela and Miljković, Milica and Ivanišević, Jasmina and Kotur-Stevuljević, Jelena", year = "2012", abstract = "The study was designed to evaluate and compare the effects of single oral (or) and intraperitoneal (i.p.) cadmium (Cd) administration on parameters of oxidative stress in liver of rats. Furthermore, investigation on protective effects of magnesium (Mg) or and i.p. pretreatment on the same parameters was performed. Wistar rats were administrated oral dose of Cd (30 mg Cd/kg b.w.)/Cd + Mg (30 mg Cd/kg b.w., 50 mg Mg/kg b.w.) or i.p. dose of Cd (1.5 mg Cd/kg b.w.)/Cd + Mg (1.5 mg Cd/kg b.w., 3 mg Mg/kg b.w.) and sacrificed after 24 h. In liver homogenates superoxide anion, malondialdehyde, non-protein sulfhydryl groups, total sulfhydryl groups content, and superoxide dismutase activity were determined. Cadmium intoxication caused the increase of superoxide anion and malondialdehyde levels and had negative effect on investigated parameters of antioxidant defense system, except on total sulfhydryl groups. The negative effect was more emphasized after i.p. Cd administration. Oral Mg pretreatment induced more pronounced positive effect than Mg given intraperitoneally that can be attributed, at least partly, to Cd and Mg interactions on the level of GIT. On the basis of the obtained results it can be concluded that both Cd and Cd + Mg effects on parameters of oxidative stress in rats liver are route-dependent.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Food and Chemical Toxicology", title = "Route-dependent effects of cadmium/cadmium and magnesium acute treatment on parameters of oxidative stress in rat liver", volume = "50", number = "3-4", pages = "552-557", doi = "10.1016/j.fct.2011.12.035" }
Matović, V., Buha, A., Bulat, Z., Đukić-Ćosić, D., Miljković, M., Ivanišević, J.,& Kotur-Stevuljević, J.. (2012). Route-dependent effects of cadmium/cadmium and magnesium acute treatment on parameters of oxidative stress in rat liver. in Food and Chemical Toxicology Pergamon-Elsevier Science Ltd, Oxford., 50(3-4), 552-557. https://doi.org/10.1016/j.fct.2011.12.035
Matović V, Buha A, Bulat Z, Đukić-Ćosić D, Miljković M, Ivanišević J, Kotur-Stevuljević J. Route-dependent effects of cadmium/cadmium and magnesium acute treatment on parameters of oxidative stress in rat liver. in Food and Chemical Toxicology. 2012;50(3-4):552-557. doi:10.1016/j.fct.2011.12.035 .
Matović, Vesna, Buha, Aleksandra, Bulat, Zorica, Đukić-Ćosić, Danijela, Miljković, Milica, Ivanišević, Jasmina, Kotur-Stevuljević, Jelena, "Route-dependent effects of cadmium/cadmium and magnesium acute treatment on parameters of oxidative stress in rat liver" in Food and Chemical Toxicology, 50, no. 3-4 (2012):552-557, https://doi.org/10.1016/j.fct.2011.12.035 . .