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Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy
dc.creator | Simić-Ogrizović, Sanja | |
dc.creator | Bojić, Suzana | |
dc.creator | Basta-Jovanović, Gordana | |
dc.creator | Radojević, Sanja | |
dc.creator | Pavlović, Jelena | |
dc.creator | Kotur-Stevuljević, Jelena | |
dc.creator | Dopsaj, Violeta | |
dc.creator | Naumović, Radomir | |
dc.date.accessioned | 2019-09-02T11:32:22Z | |
dc.date.available | 2019-09-02T11:32:22Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0278-0240 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1842 | |
dc.description.abstract | Objectives. Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 +/- 12.23 years with different kidney diseases over three years after kidney biopsy. Materials and Methods. Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later Results. Significantly positive correlations between tissue KIM-1 expression and age (r = 0.313), TIN inflammation (r = 0.456), fibrosis (r = 0.317), and proteinuria at 6 months (r = 0.394) as well as negative correlations with GFR0 (r = -0.572), GFR6 (r = -0.442), GFR24 (r = -0.398), and GFR36 (r = -0.412) were found. Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression (p = 0.016) was a predictor only at 6 months after biopsy. Conclusion. Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest. | en |
dc.publisher | Hindawi Publishing Corporation, New York | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175089/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Disease Markers | |
dc.title | Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy | en |
dc.type | article | |
dc.rights.license | BY | |
dcterms.abstract | Допсај, Виолета; Павловић, Јелена; Котур-Стевуљевић, Јелена; Симић-Огризовић, Сања; Наумовић, Радомир; Бојић, Сузана; Баста-Јовановић, Гордана; Радојевић, Сања; | |
dc.citation.spage | 567 | |
dc.citation.epage | 572 | |
dc.citation.other | : 567-572 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000326537100001 | |
dc.identifier.doi | 10.1155/2013/183246 | |
dc.identifier.pmid | 24282337 | |
dc.identifier.scopus | 2-s2.0-84890422684 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/640/1840.pdf | |
dc.type.version | publishedVersion |