An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets
Само за регистроване кориснике
1998
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The purpose of this study was to investigate the possibility of developing different levels of in vitro-in vivo correlation for immediate-release paracetamol tablets using in vitro dissolution data obtained under various experimental conditions. The influence of agitation intensity and pH value of the dissolution media was investigated. The level B approach, using statistical moment analysis led to poor correlation results. The results obtained by numerical deconvolution in order to study level A correlation indicated that good correlation should be sought with moderate levels of agitation (beyond 50 rpm in rotating basket apparatus). Results obtained by numerical convolution showed the highest level of correlation, level A, with one-to-one relationship between observed and predicted in vivo profiles.
Извор:
European Journal of Drug Metabolism and Pharmacokinetics, 1998, 23, 1, 33-40Издавач:
- Medecine Et Hygiene, Geneva 4
DOI: 10.1007/BF03189824
ISSN: 0378-7966
PubMed: 9625270
WoS: 000073649000006
Scopus: 2-s2.0-0031972196
Институција/група
PharmacyTY - JOUR AU - Radovanović, J AU - Đurić, Zorica AU - Jovanović, M AU - Ibrić, Svetlana AU - Petrović, M PY - 1998 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/185 AB - The purpose of this study was to investigate the possibility of developing different levels of in vitro-in vivo correlation for immediate-release paracetamol tablets using in vitro dissolution data obtained under various experimental conditions. The influence of agitation intensity and pH value of the dissolution media was investigated. The level B approach, using statistical moment analysis led to poor correlation results. The results obtained by numerical deconvolution in order to study level A correlation indicated that good correlation should be sought with moderate levels of agitation (beyond 50 rpm in rotating basket apparatus). Results obtained by numerical convolution showed the highest level of correlation, level A, with one-to-one relationship between observed and predicted in vivo profiles. PB - Medecine Et Hygiene, Geneva 4 T2 - European Journal of Drug Metabolism and Pharmacokinetics T1 - An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets VL - 23 IS - 1 SP - 33 EP - 40 DO - 10.1007/BF03189824 ER -
@article{ author = "Radovanović, J and Đurić, Zorica and Jovanović, M and Ibrić, Svetlana and Petrović, M", year = "1998", abstract = "The purpose of this study was to investigate the possibility of developing different levels of in vitro-in vivo correlation for immediate-release paracetamol tablets using in vitro dissolution data obtained under various experimental conditions. The influence of agitation intensity and pH value of the dissolution media was investigated. The level B approach, using statistical moment analysis led to poor correlation results. The results obtained by numerical deconvolution in order to study level A correlation indicated that good correlation should be sought with moderate levels of agitation (beyond 50 rpm in rotating basket apparatus). Results obtained by numerical convolution showed the highest level of correlation, level A, with one-to-one relationship between observed and predicted in vivo profiles.", publisher = "Medecine Et Hygiene, Geneva 4", journal = "European Journal of Drug Metabolism and Pharmacokinetics", title = "An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets", volume = "23", number = "1", pages = "33-40", doi = "10.1007/BF03189824" }
Radovanović, J., Đurić, Z., Jovanović, M., Ibrić, S.,& Petrović, M.. (1998). An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets. in European Journal of Drug Metabolism and Pharmacokinetics Medecine Et Hygiene, Geneva 4., 23(1), 33-40. https://doi.org/10.1007/BF03189824
Radovanović J, Đurić Z, Jovanović M, Ibrić S, Petrović M. An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets. in European Journal of Drug Metabolism and Pharmacokinetics. 1998;23(1):33-40. doi:10.1007/BF03189824 .
Radovanović, J, Đurić, Zorica, Jovanović, M, Ibrić, Svetlana, Petrović, M, "An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets" in European Journal of Drug Metabolism and Pharmacokinetics, 23, no. 1 (1998):33-40, https://doi.org/10.1007/BF03189824 . .