Evaluation of in vivo effects on surfactant-irritated human skin, antioxidant properties and phenolic composition of five Ericaceae species extracts
Autori
Pavlović, Dragana R.Tasić-Kostov, Marija
Marčetić, Mirjana
Lakušić, Branislava
Kitić, Dušanka
Savić, Snežana
Kovačević, Nada
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Arbutus unedo, Bruckentalia spiculifolia, Calluna vulgaris, Erica arborea and Erica carnea possess strong antioxidant activity and they are traditionally used for the treatment of various skin diseases. The present study investigated the total phenylpropanoid content, antioxidant properties and phenolic composition of dry leaf ethanol extracts of these species. Furthermore, the in vivo effects of gels, each containing 2% of a single extract were tested on the artificially irritated human skin using the objective methods of skin biophysical measurements (erythema index (EI), pH of the skin and electrical capacitance (EC) as a measure of skin hydration level were assessed). In total, 13 components were identified by RP-HPLC coupled with DAD detection; quercitrin, quercetin 3-O-glucoside and gallic acid were detected in all investigated samples while chlorogenic acid and quercetin were present in 4 samples. Regarding the in vivo study, all investigated gels significantly decreased the ski...n irritation level and reversed the pH of the skin disturbed by preirritation, while results were contradictory regarding skin hydration measurements. In conclusion, the assessed in vivo topical effects of investigated extracts matched well with their phenylpropanoid content as well as with assessed antioxidant activities.
Ključne reči:
Ericaceae / skin biophysical measurements / irritated human skin / antioxidant / phenylpropanoid / RP-HPLCIzvor:
RSC Advances, 2013, 90, 4, 255-264Izdavač:
- Innovhub Ssi-Area Ssog, Milano
Finansiranje / projekti:
- Preventivni, terapijski i etički pristup prekliničkim i kliničkim istraživanjima gena i modulatora redoks ćelijske signalizacije u imunskom, inflamatornom i proliferativnom odgovoru ćelije (RS-41018)
- Ispitivanje lekovitog potencijala biljaka: morfološka, hemijska i farmakološka karakterizacija (RS-173021)
Institucija/grupa
PharmacyTY - JOUR AU - Pavlović, Dragana R. AU - Tasić-Kostov, Marija AU - Marčetić, Mirjana AU - Lakušić, Branislava AU - Kitić, Dušanka AU - Savić, Snežana AU - Kovačević, Nada PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1885 AB - Arbutus unedo, Bruckentalia spiculifolia, Calluna vulgaris, Erica arborea and Erica carnea possess strong antioxidant activity and they are traditionally used for the treatment of various skin diseases. The present study investigated the total phenylpropanoid content, antioxidant properties and phenolic composition of dry leaf ethanol extracts of these species. Furthermore, the in vivo effects of gels, each containing 2% of a single extract were tested on the artificially irritated human skin using the objective methods of skin biophysical measurements (erythema index (EI), pH of the skin and electrical capacitance (EC) as a measure of skin hydration level were assessed). In total, 13 components were identified by RP-HPLC coupled with DAD detection; quercitrin, quercetin 3-O-glucoside and gallic acid were detected in all investigated samples while chlorogenic acid and quercetin were present in 4 samples. Regarding the in vivo study, all investigated gels significantly decreased the skin irritation level and reversed the pH of the skin disturbed by preirritation, while results were contradictory regarding skin hydration measurements. In conclusion, the assessed in vivo topical effects of investigated extracts matched well with their phenylpropanoid content as well as with assessed antioxidant activities. PB - Innovhub Ssi-Area Ssog, Milano T2 - RSC Advances T1 - Evaluation of in vivo effects on surfactant-irritated human skin, antioxidant properties and phenolic composition of five Ericaceae species extracts VL - 90 IS - 4 SP - 255 EP - 264 UR - https://hdl.handle.net/21.15107/rcub_farfar_1885 ER -
@article{ author = "Pavlović, Dragana R. and Tasić-Kostov, Marija and Marčetić, Mirjana and Lakušić, Branislava and Kitić, Dušanka and Savić, Snežana and Kovačević, Nada", year = "2013", abstract = "Arbutus unedo, Bruckentalia spiculifolia, Calluna vulgaris, Erica arborea and Erica carnea possess strong antioxidant activity and they are traditionally used for the treatment of various skin diseases. The present study investigated the total phenylpropanoid content, antioxidant properties and phenolic composition of dry leaf ethanol extracts of these species. Furthermore, the in vivo effects of gels, each containing 2% of a single extract were tested on the artificially irritated human skin using the objective methods of skin biophysical measurements (erythema index (EI), pH of the skin and electrical capacitance (EC) as a measure of skin hydration level were assessed). In total, 13 components were identified by RP-HPLC coupled with DAD detection; quercitrin, quercetin 3-O-glucoside and gallic acid were detected in all investigated samples while chlorogenic acid and quercetin were present in 4 samples. Regarding the in vivo study, all investigated gels significantly decreased the skin irritation level and reversed the pH of the skin disturbed by preirritation, while results were contradictory regarding skin hydration measurements. In conclusion, the assessed in vivo topical effects of investigated extracts matched well with their phenylpropanoid content as well as with assessed antioxidant activities.", publisher = "Innovhub Ssi-Area Ssog, Milano", journal = "RSC Advances", title = "Evaluation of in vivo effects on surfactant-irritated human skin, antioxidant properties and phenolic composition of five Ericaceae species extracts", volume = "90", number = "4", pages = "255-264", url = "https://hdl.handle.net/21.15107/rcub_farfar_1885" }
Pavlović, D. R., Tasić-Kostov, M., Marčetić, M., Lakušić, B., Kitić, D., Savić, S.,& Kovačević, N.. (2013). Evaluation of in vivo effects on surfactant-irritated human skin, antioxidant properties and phenolic composition of five Ericaceae species extracts. in RSC Advances Innovhub Ssi-Area Ssog, Milano., 90(4), 255-264. https://hdl.handle.net/21.15107/rcub_farfar_1885
Pavlović DR, Tasić-Kostov M, Marčetić M, Lakušić B, Kitić D, Savić S, Kovačević N. Evaluation of in vivo effects on surfactant-irritated human skin, antioxidant properties and phenolic composition of five Ericaceae species extracts. in RSC Advances. 2013;90(4):255-264. https://hdl.handle.net/21.15107/rcub_farfar_1885 .
Pavlović, Dragana R., Tasić-Kostov, Marija, Marčetić, Mirjana, Lakušić, Branislava, Kitić, Dušanka, Savić, Snežana, Kovačević, Nada, "Evaluation of in vivo effects on surfactant-irritated human skin, antioxidant properties and phenolic composition of five Ericaceae species extracts" in RSC Advances, 90, no. 4 (2013):255-264, https://hdl.handle.net/21.15107/rcub_farfar_1885 .