Selenium, Zinc, and Copper Plasma Levels in Patients with Schizophrenia: Relationship with Metabolic Risk Factors
Samo za registrovane korisnike
2013
Autori
Vidović, BojanaĐorđević, Brižita
Milovanović, Srđan
Skrivanj, Sandra
Pavlović, Zoran
Stefanović, Aleksandra
Kotur-Stevuljević, Jelena
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The aim of this study was to determine the plasma selenium (Se), copper (Cu), and zinc (Zn) levels and to evaluate their possible association with metabolic syndrome (MetS) components in patients with schizophrenia. The study group consisted of 60 patients with schizophrenia and 60 sex- and age-matched healthy controls. Anthropometric measurements, blood pressure, and biochemical analysis of fasting blood were performed in all subjects. Patients with schizophrenia had significantly higher plasma Cu concentrations compared with controls (0.97 +/- 0.31 vs. 0.77 +/- 0.32 mg/L, p = 0.001). The plasma Cu concentration showed a positive correlation with plasma glucose and diastolic blood pressure in the patient groups (r (s) = 0.263, p lt 0.05 and r (s) = 0.272, p lt 0.05, respectively). The plasma Se level correlated positive with MetS score (r (s) = 0.385, p lt 0.01), waist circumference (r (s) = 0.344, p lt 0.05), plasma glucose (r (s) = 0.319, p lt 0.05), and triglyceride conce...ntrations (r (s) = 0.462, p lt 0.001) in patients with schizophrenia. Plasma Zn did not correlate with any of the MetS components. These results suggest that alterations in plasma Cu and Se levels in medicated patients with schizophrenia could be associated with metabolic risk factors.
Ključne reči:
Selenium / Copper / Zinc / Metabolic syndrome / SchizophreniaIzvor:
Biological Trace Element Research, 2013, 156, 1-3, 22-28Izdavač:
- Humana Press Inc, Totowa
Finansiranje / projekti:
DOI: 10.1007/s12011-013-9842-1
ISSN: 0163-4984
PubMed: 24150923
WoS: 000327897800004
Scopus: 2-s2.0-84890803241
Institucija/grupa
PharmacyTY - JOUR AU - Vidović, Bojana AU - Đorđević, Brižita AU - Milovanović, Srđan AU - Skrivanj, Sandra AU - Pavlović, Zoran AU - Stefanović, Aleksandra AU - Kotur-Stevuljević, Jelena PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1906 AB - The aim of this study was to determine the plasma selenium (Se), copper (Cu), and zinc (Zn) levels and to evaluate their possible association with metabolic syndrome (MetS) components in patients with schizophrenia. The study group consisted of 60 patients with schizophrenia and 60 sex- and age-matched healthy controls. Anthropometric measurements, blood pressure, and biochemical analysis of fasting blood were performed in all subjects. Patients with schizophrenia had significantly higher plasma Cu concentrations compared with controls (0.97 +/- 0.31 vs. 0.77 +/- 0.32 mg/L, p = 0.001). The plasma Cu concentration showed a positive correlation with plasma glucose and diastolic blood pressure in the patient groups (r (s) = 0.263, p lt 0.05 and r (s) = 0.272, p lt 0.05, respectively). The plasma Se level correlated positive with MetS score (r (s) = 0.385, p lt 0.01), waist circumference (r (s) = 0.344, p lt 0.05), plasma glucose (r (s) = 0.319, p lt 0.05), and triglyceride concentrations (r (s) = 0.462, p lt 0.001) in patients with schizophrenia. Plasma Zn did not correlate with any of the MetS components. These results suggest that alterations in plasma Cu and Se levels in medicated patients with schizophrenia could be associated with metabolic risk factors. PB - Humana Press Inc, Totowa T2 - Biological Trace Element Research T1 - Selenium, Zinc, and Copper Plasma Levels in Patients with Schizophrenia: Relationship with Metabolic Risk Factors VL - 156 IS - 1-3 SP - 22 EP - 28 DO - 10.1007/s12011-013-9842-1 ER -
@article{ author = "Vidović, Bojana and Đorđević, Brižita and Milovanović, Srđan and Skrivanj, Sandra and Pavlović, Zoran and Stefanović, Aleksandra and Kotur-Stevuljević, Jelena", year = "2013", abstract = "The aim of this study was to determine the plasma selenium (Se), copper (Cu), and zinc (Zn) levels and to evaluate their possible association with metabolic syndrome (MetS) components in patients with schizophrenia. The study group consisted of 60 patients with schizophrenia and 60 sex- and age-matched healthy controls. Anthropometric measurements, blood pressure, and biochemical analysis of fasting blood were performed in all subjects. Patients with schizophrenia had significantly higher plasma Cu concentrations compared with controls (0.97 +/- 0.31 vs. 0.77 +/- 0.32 mg/L, p = 0.001). The plasma Cu concentration showed a positive correlation with plasma glucose and diastolic blood pressure in the patient groups (r (s) = 0.263, p lt 0.05 and r (s) = 0.272, p lt 0.05, respectively). The plasma Se level correlated positive with MetS score (r (s) = 0.385, p lt 0.01), waist circumference (r (s) = 0.344, p lt 0.05), plasma glucose (r (s) = 0.319, p lt 0.05), and triglyceride concentrations (r (s) = 0.462, p lt 0.001) in patients with schizophrenia. Plasma Zn did not correlate with any of the MetS components. These results suggest that alterations in plasma Cu and Se levels in medicated patients with schizophrenia could be associated with metabolic risk factors.", publisher = "Humana Press Inc, Totowa", journal = "Biological Trace Element Research", title = "Selenium, Zinc, and Copper Plasma Levels in Patients with Schizophrenia: Relationship with Metabolic Risk Factors", volume = "156", number = "1-3", pages = "22-28", doi = "10.1007/s12011-013-9842-1" }
Vidović, B., Đorđević, B., Milovanović, S., Skrivanj, S., Pavlović, Z., Stefanović, A.,& Kotur-Stevuljević, J.. (2013). Selenium, Zinc, and Copper Plasma Levels in Patients with Schizophrenia: Relationship with Metabolic Risk Factors. in Biological Trace Element Research Humana Press Inc, Totowa., 156(1-3), 22-28. https://doi.org/10.1007/s12011-013-9842-1
Vidović B, Đorđević B, Milovanović S, Skrivanj S, Pavlović Z, Stefanović A, Kotur-Stevuljević J. Selenium, Zinc, and Copper Plasma Levels in Patients with Schizophrenia: Relationship with Metabolic Risk Factors. in Biological Trace Element Research. 2013;156(1-3):22-28. doi:10.1007/s12011-013-9842-1 .
Vidović, Bojana, Đorđević, Brižita, Milovanović, Srđan, Skrivanj, Sandra, Pavlović, Zoran, Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, "Selenium, Zinc, and Copper Plasma Levels in Patients with Schizophrenia: Relationship with Metabolic Risk Factors" in Biological Trace Element Research, 156, no. 1-3 (2013):22-28, https://doi.org/10.1007/s12011-013-9842-1 . .