Radioprotectors - the Evergreen Topic
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2013
Authors
Kuntić, VesnaStanković, Miroslava
Vujić, Zorica
Brborić, Jasmina
Uskoković-Marković, Snežana
Article (Published version)
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Show full item recordAbstract
To protect organisms from ionizing radiation (IR), and to reduce morbidity or mortality, various agents, called radioprotectors, have been utilized. Because radiation-induced cellular damage is attributed primarily to the harmful effects of free radicals, molecules with radical-scavenging properties are particularly promising as radioprotectors. Early development of such agents focused on thiol synthetic compounds, known as WR protectors, but only amifostine (WR-2721) has been used in clinical trials as an officially approved radioprotector. Besides thiol compounds, various compounds with different chemical structure were investigated, but an ideal radioprotector has not been found yet. Plants and natural products have been evaluated as promising sources of radioprotectors because of their low toxicity, although they exhibit an inferior protection level compared to synthetic thiol compounds. Active plant constituents seem to exert the radioprotection through antioxidant and free radica...l-scavenging activities. Our research established that plants containing polyphenolic compounds (raspberry, blueberry, strawberry, grape, etc.) exhibit antioxidative activities and protect genetic material from IR.
Keywords:
Radioprotectors / Ionizing radiation / Antioxidant activity / Radical-scavenging activity / PolyphenolsSource:
Chemistry & Biodiversity, 2013, 10, 10, 1791-1803Publisher:
- Wiley-VCH Verlag GMBH, Weinheim
Funding / projects:
- Development of molecules with antiinflammatory and cardioprotective activity: structural modifications, modelling, physicochemical characterization and formulation investigations (RS-MESTD-Basic Research (BR or ON)-172041)
DOI: 10.1002/cbdv.201300054
ISSN: 1612-1872
PubMed: 24130023
WoS: 000328134400004
Scopus: 2-s2.0-84886001080
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Institution/Community
PharmacyTY - JOUR AU - Kuntić, Vesna AU - Stanković, Miroslava AU - Vujić, Zorica AU - Brborić, Jasmina AU - Uskoković-Marković, Snežana PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1910 AB - To protect organisms from ionizing radiation (IR), and to reduce morbidity or mortality, various agents, called radioprotectors, have been utilized. Because radiation-induced cellular damage is attributed primarily to the harmful effects of free radicals, molecules with radical-scavenging properties are particularly promising as radioprotectors. Early development of such agents focused on thiol synthetic compounds, known as WR protectors, but only amifostine (WR-2721) has been used in clinical trials as an officially approved radioprotector. Besides thiol compounds, various compounds with different chemical structure were investigated, but an ideal radioprotector has not been found yet. Plants and natural products have been evaluated as promising sources of radioprotectors because of their low toxicity, although they exhibit an inferior protection level compared to synthetic thiol compounds. Active plant constituents seem to exert the radioprotection through antioxidant and free radical-scavenging activities. Our research established that plants containing polyphenolic compounds (raspberry, blueberry, strawberry, grape, etc.) exhibit antioxidative activities and protect genetic material from IR. PB - Wiley-VCH Verlag GMBH, Weinheim T2 - Chemistry & Biodiversity T1 - Radioprotectors - the Evergreen Topic VL - 10 IS - 10 SP - 1791 EP - 1803 DO - 10.1002/cbdv.201300054 ER -
@article{ author = "Kuntić, Vesna and Stanković, Miroslava and Vujić, Zorica and Brborić, Jasmina and Uskoković-Marković, Snežana", year = "2013", abstract = "To protect organisms from ionizing radiation (IR), and to reduce morbidity or mortality, various agents, called radioprotectors, have been utilized. Because radiation-induced cellular damage is attributed primarily to the harmful effects of free radicals, molecules with radical-scavenging properties are particularly promising as radioprotectors. Early development of such agents focused on thiol synthetic compounds, known as WR protectors, but only amifostine (WR-2721) has been used in clinical trials as an officially approved radioprotector. Besides thiol compounds, various compounds with different chemical structure were investigated, but an ideal radioprotector has not been found yet. Plants and natural products have been evaluated as promising sources of radioprotectors because of their low toxicity, although they exhibit an inferior protection level compared to synthetic thiol compounds. Active plant constituents seem to exert the radioprotection through antioxidant and free radical-scavenging activities. Our research established that plants containing polyphenolic compounds (raspberry, blueberry, strawberry, grape, etc.) exhibit antioxidative activities and protect genetic material from IR.", publisher = "Wiley-VCH Verlag GMBH, Weinheim", journal = "Chemistry & Biodiversity", title = "Radioprotectors - the Evergreen Topic", volume = "10", number = "10", pages = "1791-1803", doi = "10.1002/cbdv.201300054" }
Kuntić, V., Stanković, M., Vujić, Z., Brborić, J.,& Uskoković-Marković, S.. (2013). Radioprotectors - the Evergreen Topic. in Chemistry & Biodiversity Wiley-VCH Verlag GMBH, Weinheim., 10(10), 1791-1803. https://doi.org/10.1002/cbdv.201300054
Kuntić V, Stanković M, Vujić Z, Brborić J, Uskoković-Marković S. Radioprotectors - the Evergreen Topic. in Chemistry & Biodiversity. 2013;10(10):1791-1803. doi:10.1002/cbdv.201300054 .
Kuntić, Vesna, Stanković, Miroslava, Vujić, Zorica, Brborić, Jasmina, Uskoković-Marković, Snežana, "Radioprotectors - the Evergreen Topic" in Chemistry & Biodiversity, 10, no. 10 (2013):1791-1803, https://doi.org/10.1002/cbdv.201300054 . .