Relationship between bone resorption, oxidative stress and inflammation in severe COPD exacerbation
Samo za registrovane korisnike
2013
Autori
Stanojković, IvanaKotur-Stevuljević, Jelena
Spasić, Slavica
Milenković, Branislava
Vujić, Tatjana
Stefanović, Aleksandra
Ivanišević, Jasmina
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Background: The natural course of chronic obstructive pulmonary disease (COPD) is complicated by the development of systemic consequences and co-morbidities. Increasing evidence indicates that COPD and osteoporosis are strongly linked. The common features in COPD pathology, history of smoking, age, inactivity, systemic inflammation, and use of systemic corticosteroids, are important risk factors for osteoporosis. Methods: Pulmonary function, matrix metalloproteinase, tissue inhibitor of metalloproteinases, oxidative stress parameters, inflammatory markers and bone resorption marker were measured in 85 COPD patients and 47 healthy subjects. In patients, all parameters were assessed at two time points: one day after admission during exacerbation and about 30 days after, in the stable state of disease. Results: In patients, bone resorption marker collagen type I p-isomerized C-terminal telopeptide (beta CL) was increased during exacerbation: geometric mean 0.521, compared with stable pati...ents 0.408, p lt 0.01, and control subjects 0.362 ng/ml, p lt 0.001. During exacerbation high sensitivity C-reactive protein (hsCRP) and neutrophil count were significantly higher in COPD patients compared with the control group, p lt 0.001. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations were significantly higher in COPD patients, stable state or exacerbation, compared with control subjects, p lt 0.001. In patients during exacerbation, total oxidative status (TOS) was higher compared with the stable state, p lt 0.05 and control group, p lt 0.001. Multiple linear regression for the joint influence of inflammation, hypoxia and oxidative status during exacerbation showed almost 60% influence on the variability of beta CL concentrations. Conclusion: Intensification of disease characteristic symptoms such as inflammation, hypoxia, protease/antiprotease imbalance and oxidative stress, during exacerbation episodes in COPD patients may also contribute to increased bone resorption.
Ključne reči:
Bone resorption / Oxidative stress / Inflammation / COPD exacerbationIzvor:
Clinical Biochemistry, 2013, 46, 16-17, 1678-1682Izdavač:
- Pergamon-Elsevier Science Ltd, Oxford
Finansiranje / projekti:
- Interaktivna uloga dislipidemije, oksidativnog stresa i inflamacije u aterosklerozi i drugim bolestima: genetički i biohemijski markeri (RS-MESTD-Basic Research (BR or ON)-175035)
DOI: 10.1016/j.clinbiochem.2013.08.003
ISSN: 0009-9120
PubMed: 23954853
WoS: 000326362100012
Scopus: 2-s2.0-84886381846
Institucija/grupa
PharmacyTY - JOUR AU - Stanojković, Ivana AU - Kotur-Stevuljević, Jelena AU - Spasić, Slavica AU - Milenković, Branislava AU - Vujić, Tatjana AU - Stefanović, Aleksandra AU - Ivanišević, Jasmina PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1922 AB - Background: The natural course of chronic obstructive pulmonary disease (COPD) is complicated by the development of systemic consequences and co-morbidities. Increasing evidence indicates that COPD and osteoporosis are strongly linked. The common features in COPD pathology, history of smoking, age, inactivity, systemic inflammation, and use of systemic corticosteroids, are important risk factors for osteoporosis. Methods: Pulmonary function, matrix metalloproteinase, tissue inhibitor of metalloproteinases, oxidative stress parameters, inflammatory markers and bone resorption marker were measured in 85 COPD patients and 47 healthy subjects. In patients, all parameters were assessed at two time points: one day after admission during exacerbation and about 30 days after, in the stable state of disease. Results: In patients, bone resorption marker collagen type I p-isomerized C-terminal telopeptide (beta CL) was increased during exacerbation: geometric mean 0.521, compared with stable patients 0.408, p lt 0.01, and control subjects 0.362 ng/ml, p lt 0.001. During exacerbation high sensitivity C-reactive protein (hsCRP) and neutrophil count were significantly higher in COPD patients compared with the control group, p lt 0.001. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations were significantly higher in COPD patients, stable state or exacerbation, compared with control subjects, p lt 0.001. In patients during exacerbation, total oxidative status (TOS) was higher compared with the stable state, p lt 0.05 and control group, p lt 0.001. Multiple linear regression for the joint influence of inflammation, hypoxia and oxidative status during exacerbation showed almost 60% influence on the variability of beta CL concentrations. Conclusion: Intensification of disease characteristic symptoms such as inflammation, hypoxia, protease/antiprotease imbalance and oxidative stress, during exacerbation episodes in COPD patients may also contribute to increased bone resorption. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Clinical Biochemistry T1 - Relationship between bone resorption, oxidative stress and inflammation in severe COPD exacerbation VL - 46 IS - 16-17 SP - 1678 EP - 1682 DO - 10.1016/j.clinbiochem.2013.08.003 ER -
@article{ author = "Stanojković, Ivana and Kotur-Stevuljević, Jelena and Spasić, Slavica and Milenković, Branislava and Vujić, Tatjana and Stefanović, Aleksandra and Ivanišević, Jasmina", year = "2013", abstract = "Background: The natural course of chronic obstructive pulmonary disease (COPD) is complicated by the development of systemic consequences and co-morbidities. Increasing evidence indicates that COPD and osteoporosis are strongly linked. The common features in COPD pathology, history of smoking, age, inactivity, systemic inflammation, and use of systemic corticosteroids, are important risk factors for osteoporosis. Methods: Pulmonary function, matrix metalloproteinase, tissue inhibitor of metalloproteinases, oxidative stress parameters, inflammatory markers and bone resorption marker were measured in 85 COPD patients and 47 healthy subjects. In patients, all parameters were assessed at two time points: one day after admission during exacerbation and about 30 days after, in the stable state of disease. Results: In patients, bone resorption marker collagen type I p-isomerized C-terminal telopeptide (beta CL) was increased during exacerbation: geometric mean 0.521, compared with stable patients 0.408, p lt 0.01, and control subjects 0.362 ng/ml, p lt 0.001. During exacerbation high sensitivity C-reactive protein (hsCRP) and neutrophil count were significantly higher in COPD patients compared with the control group, p lt 0.001. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations were significantly higher in COPD patients, stable state or exacerbation, compared with control subjects, p lt 0.001. In patients during exacerbation, total oxidative status (TOS) was higher compared with the stable state, p lt 0.05 and control group, p lt 0.001. Multiple linear regression for the joint influence of inflammation, hypoxia and oxidative status during exacerbation showed almost 60% influence on the variability of beta CL concentrations. Conclusion: Intensification of disease characteristic symptoms such as inflammation, hypoxia, protease/antiprotease imbalance and oxidative stress, during exacerbation episodes in COPD patients may also contribute to increased bone resorption.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Clinical Biochemistry", title = "Relationship between bone resorption, oxidative stress and inflammation in severe COPD exacerbation", volume = "46", number = "16-17", pages = "1678-1682", doi = "10.1016/j.clinbiochem.2013.08.003" }
Stanojković, I., Kotur-Stevuljević, J., Spasić, S., Milenković, B., Vujić, T., Stefanović, A.,& Ivanišević, J.. (2013). Relationship between bone resorption, oxidative stress and inflammation in severe COPD exacerbation. in Clinical Biochemistry Pergamon-Elsevier Science Ltd, Oxford., 46(16-17), 1678-1682. https://doi.org/10.1016/j.clinbiochem.2013.08.003
Stanojković I, Kotur-Stevuljević J, Spasić S, Milenković B, Vujić T, Stefanović A, Ivanišević J. Relationship between bone resorption, oxidative stress and inflammation in severe COPD exacerbation. in Clinical Biochemistry. 2013;46(16-17):1678-1682. doi:10.1016/j.clinbiochem.2013.08.003 .
Stanojković, Ivana, Kotur-Stevuljević, Jelena, Spasić, Slavica, Milenković, Branislava, Vujić, Tatjana, Stefanović, Aleksandra, Ivanišević, Jasmina, "Relationship between bone resorption, oxidative stress and inflammation in severe COPD exacerbation" in Clinical Biochemistry, 46, no. 16-17 (2013):1678-1682, https://doi.org/10.1016/j.clinbiochem.2013.08.003 . .