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Artificial neural networks in analysis of indinavir and its degradation products retention
(Elsevier Science BV, Amsterdam, 2009)
Artificial neural networks (ANN) are biologically inspired computer programs designed to simulate the way in which the human brain processes the information. In the past few years, coupling of experimental design (ED) and ...
Rational utilization of drugs in treatment of arterial hypertension
(Lippincott Williams & Wilkins, Philadelphia, 2008)
Kinetic determination of morphine by means of Bray-Liebhafsky oscillatory reaction system using analyte pulse perturbation technique
(Elsevier Science BV, Amsterdam, 2007)
A novel kinetic method for micro-quantitative determinations of morphine (MH) is proposed and validated. The method is based on the potentiometric monitoring of the concentration perturbations of the oscillatory reaction ...
Association of oxidative stress and paraoxonase status with PROCAM risk score
(Pergamon-Elsevier Science Ltd, Oxford, 2009)
Objectives: Oxidative stress and paraoxonase activity play a significant role in the pathogenesis of cardiovascular disease (CVD). The Prospective Cardiovascular Munster (PROCAM) study evaluated the prevalence of CVD risk ...
An Investigation into the Importance of "Very Rapid Dissolution" Criteria for Drug Bioequivalence Demonstration using Gastrointestinal Simulation Technology
(Springer, New York, 2009)
The Biopharmaceutics Classification System (BCS) is based on the mechanistic assumptions that the rate and extent of oral drug absorption are governed by drug solubility, intestinal permeability, and dissolution rate from ...
Topical Vehicles Based on Natural Surfactant/Fatty Alcohols Mixed Emulsifier: The Influence of Two Polyols on the Colloidal Structure and In Vitro/In Vivo Skin Performance
(Elsevier Science Inc, New York, 2009)
There is a growing need for in-depth research into new skill- and environment-friendly surfactants, such as alkylpolyglucosides. The aim of this study was to assess whether, to which extent and by what mechanism the two ...
Synthesis, characterization and antimicrobial activity of Co(II), Zn(II) and Cd(II) complexes with N-benzyloxycarbonyl-S-phenylalanine
(Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux, 2009)
In this paper the first complexes of M2+ ions (M2+ = Zn2+, Cd2+ and Co2+) with N-benzyloxycarbonyl-S-phenylalaninato ligand (1-3) are described. The new complexes were characterized by means of elemental analysis, IR and ...
Association of oxidative stress and PON1 with LDL and HDL particle size in middle-aged subjects
(Wiley, Hoboken, 2007)
Background Alterations in plasma lipoprotein subclass distributions affect atherosclerosis risk. Smaller, denser low-density lipoprotein (LDL) particles (sdLDL) are more susceptible to oxidation. In contrast, most of the ...
A Validated Enantiospecific Method for Determination and Purity Assay of Clopridogrel
(Wiley, Hoboken, 2009)
A new and accurate HPLC method using beta-cyclodextrin chemically bonded to spherical silica particles as chiral stationary phase (CSP) was developed and validated for determination of S-clopidogrel and its impurities ...
Apolipoprotein E polymorphism in the Serbian general population and effect on lipid parameters in the middle-aged subjects
(Elsevier Ireland Ltd, Clare, 2007)