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Sesquiterpene lactones from the extracts of two Balkan endemic Laserpitium species and their cytotoxic activity
(Pergamon-Elsevier Science Ltd, Oxford, 2013)
Chloroform extracts of the underground parts of two Balkan endemic Laserpitium species, Laserpitium zernyi Hayek and Laserpitium ochridanum Micevski, were chemically investigated. Five unknown guaianolides from the class ...
Population pharmacokinetics of topiramate in adult patients with epilepsy using nonlinear mixed effects modelling
(Elsevier Science BV, Amsterdam, 2013)
The objective of the study was to develop population pharmacokinetic model of topiramate (TPM) using nonlinear mixed effects modelling approach. Data were collected from 78 adult epileptic patients on mono- or co-therapy ...
Salivary IgA response to astaxanthin supplementation in young soccer players
(Cambridge Univ Press, Cambridge, 2013)
Habitual exercise at an intense level can cause suppression of mucosal immune parameters (1)
. We investigated the effect of astaxanthin
(Asx) supplementation on salivary IgA (sIgA) concentration and secretion rate in ...
Route, dose and duration of exposure to cadmium-relevance to oxidative stress induction
(Nova Science Publishers, Inc., 2013)
Cadmium (Cd) is a toxic metal currently ranked as seventh (out of 275) on ATSDR priority list of hazardous substances and it is considered as one of the most important occupational and environmental pollutants. This ...
The Pharmacokinetics of Recombinant Human Erythropoietin in Balkan Endemic Nephropathy Patients
(Soc Espanola Nefrologia Dr Rafael Matesanz, Madrid, 2013)
Background: Balkan endemic nephropathy (BEN) hemodialysis patients require a higher dose of recombinant human erythropoietin for maintaining target hemoglobin level than patients with other kidney diseases. Objectives: ...
Evaluation of Seven Chromatographic Response Functions on Simulated and Experimentally Obtained Chromatograms in Hydrophilic Interaction Liquid Chromatography System
(Taylor & Francis Inc, Philadelphia, 2013)
This paper investigates the ability of seven chromatographic response functions to measure the quality of chromatograms obtained in hydrophilic interaction liquid chromatography (HILIC). First, the functions were tested ...
TLC determination of glimepiride and its main impurities in pharmaceuticals
(Taylor & Francis Inc, Philadelphia, 2013)
A quantitative TLC method was developed for the simultaneous separation and quantification of glimepiride and its main degradation impurities, glimepiride-sulfonamide, and glimepiride-carbamate. Chromatographic analysis ...
The interface of hypothalamic-pituitary-adrenocortical axis and circulating brain natriuretic peptide in prediction of cardiopulmonary performance during physical stress
(Elsevier Science Inc, New York, 2013)
Brain natriuretic peptide (NT-pro-BNP) was implicated in the regulation of hypothalamic-pituitary-adrenocortical (HPA) responses to psychological stressors. However, HPA axis activation in different physical stress models ...
pH-sensitive microparticles for oral drug delivery based on alginate/oligochitosan/Eudragit (R) L100-55 "sandwich" polyelectrolyte complex
(Elsevier Science BV, Amsterdam, 2013)
The primary objective of this study was to investigate the influence of the oligochitosan-Eudragit (R) L100-55 polyelectrolyte complex (OCH-EL PEC) on the pH-sensitivity of Eudragit (R) L100-55-treated alginate-oligochitosan ...
Forced degradation study of torasemide: Characterization of its degradation products
(Taylor & Francis Inc, Philadelphia, 2013)
Torasemide was subjected to forced degradation studies. Stress conditions were varied concerning hydrolysis (acid, base, and neutral), oxidation, photolysis, and thermal degradation in order to identify the potential ...