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Theoretical investigation of the differences in the ionization and hydrophobicity of the MAO A active site with and without serotonin
(COST (European Cooperation in Science and Technology), 2015)
Monoamine oxidase (MAO) is a mitochondrial flavoenzyme which plays an essential role in
the regulation of levels of biogenic monoamines in the human body and exists in two forms,
MAO A and MAO B. Differences of two enzymes ...
RP-HPLC and DFT study on separation of enalapril and ramipril (Z)- and (E)-diastereomers
(National Institute of Chemistry, Slovenia, 2015)
Enalapril and ramipril are structuraly very similar compounds which belong to the class of angiotensin-converting enzyme (ACE) inhibitors and can be classified as proline peptide bond-containing dipeptides. Because of a ...
Parenteral nanoemulsions as promising carriers for brain delivery of risperidone: Design, characterization and in vivo pharmacokinetic evaluation
(Elsevier Science BV, Amsterdam, 2015)
This paper describes design and evaluation of parenteral lecithin-based nanoemulsions intended for brain delivery of risperidone, a poorly water-soluble psychopharmacological drug. The nanoemulsions were prepared through ...