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Viscosity-mediated negative food effect on oral absorption of poorly-permeable drugs with an absorption window in the proximal intestine: In vitro experimental simulation and computational verification
(Elsevier Science BV, Amsterdam, 2014)
Concomitant food intake can diminish oral absorption of drugs with limited permeability and an absorption window in the proximal intestine, due to viscosity-mediated decrease in dosage form disintegration time and drug ...
Total plasma protein effect on tacrolimus elimination in kidney transplant patients - Population pharmacokinetic approach
(Elsevier Science BV, Amsterdam, 2014)
Data from routine therapeutic drug monitoring of 105 adult kidney transplant recipients were used for population pharmacokinetic analysis which was performed using a non-linear mixed-effects modeling. The effect of demographic ...
Analysis of fluidized bed granulation process using conventional and novel modeling techniques
(Elsevier Science BV, Amsterdam, 2011)
Various modeling techniques have been applied to analyze fluidized-bed granulation process. Influence of various input parameters (product, inlet and outlet air temperature, consumption of liquid-binder, granulation ...
Population pharmacokinetics of topiramate in adult patients with epilepsy using nonlinear mixed effects modelling
(Elsevier Science BV, Amsterdam, 2013)
The objective of the study was to develop population pharmacokinetic model of topiramate (TPM) using nonlinear mixed effects modelling approach. Data were collected from 78 adult epileptic patients on mono- or co-therapy ...
Ex vivo skin permeation and penetration of nonivamide from and in vivo skin tolerability of film-forming formulations containing porous silica
(Elsevier Science BV, Amsterdam, 2017)
Aim: The purpose of this study was to evaluate skin permeation and penetration of nonivamide which has been formulated in novel film-forming formulations (FFFs). These formulations aim to prolong the availability of ...
Evaluation of powder, solution and suspension layering for the preparation of enteric coated pellets
(Elsevier Science BV, Amsterdam, 2016)
Gastro-resistant pellets were prepared by use of three different drug loading techniques (powder layering, solution layering and suspension layering) and two different enteric coating techniques (powder layering and ...
Assessing the potential of solid dispersions to improve dissolution rate and bioavailability of valsartan: In vitro-in silico approach
(Elsevier Science BV, Amsterdam, 2018)
This study aimed to improve dissolution rate of valsartan in an acidic environment and consequently its oral bioavailability by solid dispersion formulation. Valsartan was selected as a model drug due to its low oral ...
Application of biopartitioning micellar chromatography and QSRR modeling for prediction of gastrointestinal absorption and design of novel beta-hydroxy-beta-arylalkanoic acids
(Elsevier Science BV, Amsterdam, 2017)
Gastrointestinal absorption of thirteen novel beta-hydroxy-beta-arylalkanoic acids (HAA) with anti-inflammatory activity was predicted by use of biopartitioning micellar chromatography and compared to ibuprofen. All tested ...
Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method
(Elsevier Science BV, Amsterdam, 2017)
The preparation and characterization of films and nanofibers with carvedilol as a poorly water-soluble drug in poly (ethylene oxide) (PEO) polymer were investigated. Films are prepared by solution casting method, and ...
A contribution to biopharmaceutical characterization of drug substances: cefaclor case
(Elsevier Science BV, Amsterdam, 2013)