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International Union of Basic and Clinical Pharmacology. CVI: GABAA Receptor Subtype- and Function-selective Ligands: Key Issues in Translation to Humans
(Amer Soc Pharmacology Experimental Therapeutics, Bethesda, 2018)
GABAA receptors are themajor inhibitory transmitter receptors in the brain. They are ligand-gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive steroids, anesthetics, and convulsants. ...
Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the gamma-Aminobutyric Acid Type A Receptor (GABA(A)R) alpha 6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability
(Amer Chemical Soc, Washington, 2018)
Recent reports indicate that alpha 6/beta 2/3 gamma 2 GABA(A)R selective ligands may be important for the treatment of trigeminal activation-related pain and neuropsychiatric disorders with sensori-motor gating deficits. ...
Route-dependent effects of cadmium/cadmium and magnesium acute treatment on parameters of oxidative stress in rat liver
(Pergamon-Elsevier Science Ltd, Oxford, 2012)
The study was designed to evaluate and compare the effects of single oral (or) and intraperitoneal (i.p.) cadmium (Cd) administration on parameters of oxidative stress in liver of rats. Furthermore, investigation on ...
Sexual dimorphism in Th17/Treg axis in lymph nodes draining inflamed joints in rats with collagen-induced arthritis
(Academic Press Inc Elsevier Science, San Diego, 2019)
Collagen type II-induced arthritis (CIA) in Dark Agouti rats, a model of rheumatoid arthritis (RA), reproduces sexual dimorphism in the incidence and severity of the human disease. Th17 cells are central in the ...
Impact of CYP2C19 Genotype on Escitalopram Exposure and Therapeutic Failure: A Retrospective Study Based on 2,087 Patients
(Amer Psychiatric Publishing, Inc, Washington, 2018)
Objective: The antidepressant escitalopram is predominantly metabolized by the polymorphic CYP2C19 enzyme. The authors investigated the effect of CYP2C19 genotype on exposure and therapeutic failure of escitalopram in a ...
Soluble sPD-L1 plasma concentrations in a series of 95 lung cancer patients
(European Respiratory Soc Journals Ltd, Sheffield, 2018)
Influence of interaction delays on noise-induced coherence in excitable systems
(Amer Physical Soc, College Pk, 2010)
Influence of the interaction time delay on the noise-induced system size resonance in a system of all-to-all electrically coupled FitzHugh-Nagumo excitable neurons is studied. It is observed that small time lags decrease ...
Salivary IgA response to astaxanthin supplementation in young soccer players
(Cambridge Univ Press, Cambridge, 2013)
Habitual exercise at an intense level can cause suppression of mucosal immune parameters (1)
. We investigated the effect of astaxanthin
(Asx) supplementation on salivary IgA (sIgA) concentration and secretion rate in ...
Application of Design of Experiments and Multilayer Perceptron Neural Network in Optimization of the Spray-Drying Process
(Taylor & Francis Inc, Philadelphia, 2011)
The aim of this study was to investigate the effect of changing spray-drying parameters on the production of a naratriptan/maltodextrin/lactose composite, as well as to evaluate the application of design of experiments and ...