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Приказ резултата 31-40 од 74
Selective COX-2 inhibitors after bariatric surgery: Celecoxib, etoricoxib and etodolac post-bariatric solubility/dissolution and pharmacokinetics
(Elsevier B.V., 2023)
Anatomical/physiological gastrointestinal changes after bariatric surgery may influence the fate of orally administered drugs. Since non-selective NSAIDs are not well-tolerated post-surgery, selective cyclooxygenase-2 ...
Discovery of Novel Thiophene/Hydrazones: In Vitro and In Silico Studies against Pancreatic Cancer
(MDPI, 2023)
Cancer is the disease with the highest mortality. Drug studies contribute to promising treatments; however there is an urgent need for selective drug candidates. Pancreatic cancer is difficult to treat and the cancer ...
Synthesis, Evaluation of Enzyme Inhibition and Redox Properties of Potential Dual COX-2 and 5-LOX Inhibitors
(MDPI, 2023)
Various dual inhibitors of COX-2 and 5-LOX enzymes have been developed so far in order to obtain more effective and safer anti-inflammatory drugs. The aim of this study was to design and synthesize new dual COX-2 and 5-LOX ...
Development of Analytical Quality by Design Compliant Chaotropic Chromatography Method for Ziprasidone and Its Five Impurities Determination
(MDPI, 2023)
In this study, an AQbD-compliant chaotropic chromatography method for ziprasidone and the determination of its five impurities was developed. The influence of critical method parameters (initial and final methanol fraction ...
Nickel as a potential disruptor of thyroid function: benchmark modelling of human data
(Frontiers Media SA, 2023)
Introduction: Nickel (Ni) is one of the well-known toxic metals found in the environment. However, its influence on thyroid function is not explored enough. Hence, the aim of this study was to analyse the potential of Ni ...
Evaluating the pharmacokinetics of intrapulmonary administered ciprofloxacin solution for respiratory infections using in vivo and in silico PBPK rat model studies
(Elsevier B.V., 2023)
Respiratory antibiotics have been proven clinically beneficial for the treatment of severe lung infections such as Pseudomonas aeruginosa. Maintaining a high local concentration of inhaled antibiotics for an extended time ...
SIRT2i_Predictor: A Machine Learning-Based Tool to Facilitate the Discovery of Novel SIRT2 Inhibitors
(MDPI, 2023)
A growing body of preclinical evidence recognized selective sirtuin 2 (SIRT2) inhibitors as novel therapeutics for treatment of age-related diseases. However, none of the SIRT2 inhibitors have reached clinical trials yet. ...
Approximate treatment of noncommutative curvature in quartic matrix model
(Springer Science and Business Media Deutschland GmbH, 2023)
We study a Hermitian matrix model with the standard quartic potential amended by a tr(RΦ2) term for fixed external matrix R. This is motivated by a curvature term in the truncated Heisenberg algebra formulation of the ...
Carbonization of MOF-5/Polyaniline Composites to N,O-Doped Carbon/ZnO/ZnS and N,O-Doped Carbon/ZnO Composites with High Specific Capacitance, Specific Surface Area and Electrical Conductivity
(MDPI, 2023)
Composites of carbons with metal oxides and metal sulfides have attracted a lot of interest as materials for energy conversion and storage applications. Herein, we report on novel N,O-doped carbon/ZnO/ZnS and N,O-doped ...
The influence of bismuth participation on the morphological and electrochemical characteristics of gallium oxide for the detection of adrenaline
(Springer Science and Business Media, 2023)
In this work, we investigated the morphological and electrochemical properties of gallium/bismuth mixed oxide. The bismuth concentration was varied from 0 to 100%. The correct ratio was determined with inductively coupled ...