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Nanocrystal dispersion of DK-I-56–1, a poorly soluble pyrazoloquinolinone positive modulator of α6 GABAA receptors: Formulation approach toward improved in vivo performance
(Elsevier B.V., 2020)
DK-I-56–1 (7‑methoxy‑2-(4‑methoxy‑d3-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one), a recently developed deuterated pyrazoloquinolinone, has been recognized as a lead candidate for treatment of various neuropsychiatric ...
Application of nanofat for treatment of traumatic faecal incontinence after sphincteroplasty – A pilot study
(John Wiley and Sons Inc, 2022)
Aim: The aim of this study was to investigate whether the application of nanofat contain-ing stem cells improves continence in women who had previously undergone anal sphinc-teroplasty with unsatisfactory long-term ...
Encapsulation and release of vitamin C in double W/O/W emulsions followed by complex coacervation in gelatin-sodium caseinate system
(Elsevier Ltd, 2021)
The objective of this study was to produce and characterize microcapsules for simultaneous encapsulation hydrophilic and lipophilic active substances. For this purpose, double emulsification process was employed, followed ...
Comparative chemometric and quantitative structure-retention relationship analysis of anisotropic lipophilicity of 1-arylsuccinimide derivatives determined in high-performance thin-layer chromatography system with aprotic solvents
(Elsevier B.V., 2020)
Numerous structurally different amides and imides including succinimide derivatives exhibit diverse bioactive potential. The development of new compounds requires rationalization in the design in or- der to provide structural ...
Simultaneous oxidation of aniline and tannic acid with peroxydisulfate: Self-assembly of oxidation products from nanorods to microspheres
(Elsevier Science Sa, Lausanne, 2012)
The oxidation of aniline with ammonium peroxydisulfate (APS) in aqueous solution of the plant-derived polyphenol, tannic acid, is reported. The effect of initial mole ratios [tannic acid]/[aniline] and [APS]/[aniline] on ...
Analysis of fluidized bed granulation process using conventional and novel modeling techniques
(Elsevier Science BV, Amsterdam, 2011)
Various modeling techniques have been applied to analyze fluidized-bed granulation process. Influence of various input parameters (product, inlet and outlet air temperature, consumption of liquid-binder, granulation ...
Spectrophotometric assay of xanthine oxidase with 2,2'-azino-di(3-ethylbenzthiazoline-6-sulphonate) (ABTS) as chromogen
(Clinica Chimica Acta, 1987)
A new method for the determination of xanthine oxidase activity, based on the oxidation of 2, 2'-azino-di(3-ethylbenzthiazoline-6-sulphonate) (ABTS) by use of uricase and peroxidase, is described. The absorbance increase ...
Chaperone proteins associate with b-amyloid peptide (ab) as part of multicomponent complex
(Wiley-Blackwell, Malden, 2011)
Gestational diabetes mellitus modulates neonatal high-density lipoprotein composition and its functional heterogeneity
(Elsevier Science BV, Amsterdam, 2014)
Gestational diabetes mellitus (GDM) is related to neonatal macrosomia and an increased risk of vascular events. We hypothesized that GDM exerts qualitative effects on neonatal high-density lipoprotein (HDL). HDL was isolated ...
Chaotropic agents in liquid chromatographic method development for the simultaneous analysis of levodopa, carbidopa, entacapone and their impurities
(Elsevier Science BV, Amsterdam, 2013)
The simultaneous pharmaceutical analysis of multi-component drugs represents a challenge due to a large total number of analytes present in the sample. These analytes are not only the active pharmaceutical ingredients, but ...