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Gradient Boosted Tree model: A fast track tool for predicting the Atmospheric Pressure Chemical Ionization-Mass Spectrometry signal of antipsychotics based on molecular features and experimental settings
(Elsevier B.V., 2022)
Predicting the response signal in Atmospheric Pressure Chemical Ionization - Mass Spectrometry (APCI-MS) systems appears to be considerably challenging due to a gap in knowledge of governing factors and nature of their ...
Synthesis of the vitamin E amino acid esters with an enhanced anticancer activity and in silico screening for new antineoplastic drugs
(Elsevier Science BV, Amsterdam, 2016)
Tocopherols and tocotrienols belong to the family of vitamin E (VE) with the well-known antioxidant properties. For certain alpha-tocopherol and gamma-tocotrienol derivatives used as the lead compounds in this study, ...
Influence of different wild-garlic (Allium ursinum) extracts on the gastrointestinal system: spasmolytic, antimicrobial and antioxidant properties
(Wiley, Hoboken, 2017)
ObjectivesAs there are no previous studies of the European wild-garlic (Allium ursinum) effects on the gastrointestinal system, despite its traditional applications in gastrointestinal disorders' treatment and regular use ...
Application of the design of experiments in optimization of drug layering of pellets with an insight into drug polymer interactions
(Elsevier Science BV, Amsterdam, 2016)
This study consists of two experimental designs. Within the first one, suitable technique for application of model drug onto inactive pellets was evaluated and formulation and process parameters with greatest impact to ...
Development and validation of RP-HPLC method for cetrimonium bromide and lidocaine determination
(Elsevier Masson SAS, 2005)
The simple and rapid RP-HPLC method, for the simultaneous determination of lidocaine and cetrimonium bromide in the presence of pellet color corrigent, was developed. Separations were performed on a Beckman Ultrasphere ODS ...
Determination of all pK(a) values of some di- and tri-carboxylic unsaturated and epoxy acids and their polylinear correlation with the carboxylic group atomic charges
(Scientific Reviews Ltd., 2003)
For a series of seven unsaturated and seven epoxy di- and tricarboxylic acids, pK(a)(a) values were determined potentiometrically in aqueous media at 25 degreesC and an ionic strength of 0.1 M (NaCl). The thermodynamic ...
Evaluation of global haemostatic assays and fibrin structure in patients with pre-eclampsia
(Wiley-Blackwell, 2020)
Introduction: Haemostatic balance shifted towards hypercoagulability in normal pregnancy is even more pronounced in pre-eclampsia (P-EC). The aim of this study was to analyse haemostatic disturbances and fibrin clot ...
Identifying the CmbT substrates specificity by using a quantitative structure-activity relationship (QSAR) study
(Elsevier Science BV, Amsterdam, 2014)
The CmbT substrate specificity and its role as a proton motive force-driven drug efflux pump at a molecular level were investigated in the study. In that order, 3D-quantitative structure-activity relationship (3D-QSAR) ...
Optimization of the lyophilisation process for esomeprazole 40 mg powder for solution for injection/infusion using quality by design concept
(Elsevier, 2022)
The aim of this work was to apply the of Quality by Design concept in optimization of lyophilisation process in production of esomeprazole 40 mg powder for solution for injection/infusion. Optimization has been triggered ...
The examination of antinociceptive and toxic effects of oxcarbazepine and carbamazepine in mice
(Blackwell Publishing, Oxford, 2006)