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Ester to amide substitution improves selectivity, efficacy and kinetic behavior of a benzodiazepine positive modulator of GABA(A) receptors containing the alpha 5 subunit
(Elsevier Science BV, Amsterdam, 2016)
We have synthesized and characterized MP-III-022 ((R)-8-ethynyl 6 (2 fluorophenyl)-N,4-dimethyl4H-benzo[f]imidazo[1,5-alpha][1,4]diazepine-3-carboxamide) in vitro and in vivo as a binding- and efficacy selective positive ...
Sex differences in the clinical presentation and therapy of multiple sclerosis / Polne razlike u kliničkoj slici i terapiji multiple skleroze
(Savez farmaceutskih udruženja Srbije, Beograd, 2016)
Multiple sclerosis (MS) is more prevalent in women than in men, with the female to male ratio in the prevalence of MS constantly increasing. Besides, sex appears to affect the development, progression, clinical manifestation ...
Radioisotopes used as radiotracers for in vitro and in vivo diagnostics
(Chemical Publishing Co., 2016)
Many of modern diagnostic methods cannot be achieved without radioisotopes. In this review, an overview of the most common radioisotopes (radionuclides) used as markers for in vitro and in vivo studies is provided. To ...
Pancreatic Elastase Levels in Feces As A Marker of Exocrine Pancreatic Function in Patients With Diabetes Mellitus
(Oxford Univ Press, Oxford, 2016)
Objective: The measurement of pancreatic elastase (PE) in feces is used widely to screen for pancreatic exocrine insufficiency. The aim of our study was to evaluate the relationship of PE with residual beta cell secretion ...
Sex-Dependent Anti-Stress Effect of an alpha 5 Subunit Containing GABA(A) Receptor Positive Allosteric Modulator
(Frontiers Media Sa, Lausanne, 2016)
Rationale: Current first-line treatments for stress related disorders such as major depressive disorder (MDD) act on monoaminergic systems and take weeks to achieve a therapeutic effect with poor response and low remission ...
Ethical aspects of the stem cells' use as healthcare technologies in personalized medicine / Etički aspekti upotrebe matičnih ćelija kao zdravstvenih tehnologija u personalizovanoj medicini
(Klinički centar Srbije - Klinika za psihijatriju, Beograd i Udruženje psihijatara Srbije, Beograd, 2016)
Objective: Stem cells could be defined as cell with an extraordinary capacity for self-renewal and the ability to differentiate into different cell types. The aim of this study is to examine students' opinion about the use ...
Potential drug-drug interactions in kidney transplant patients.
(Wiley-Blackwell, Hoboken, 2016)
Multi-analytical study of techniques and palettes of wall paintings of the monastery of Zica, Serbia
(Pergamon-Elsevier Science Ltd, Oxford, 2016)
The present multi-analytical study concentrates on establishing the painting techniques and the identity of the wall painting materials used by the artists from the 13th and 14th centuries to decorate the Zica monastery, ...
Application of Analytical Quality by Design concept for bilastine and its degradation impurities determination by hydrophilic interaction liquid chromatographic method
(Elsevier Science BV, Amsterdam, 2016)
This paper deals with the development of hydrophilic interaction liquid chromatographic (HILIC) method for the analysis of bilastine and its degradation impurities following Analytical Quality by Design approach. It is the ...
Proinflammatory proteins in female and male patients with primary antiphospholipid syndrome: preliminary data
(Springer London Ltd, London, 2016)
The latest classification criteria for the diagnosis of the antiphospholipid syndrome (APS, an autoimmune disease characterized by thromboses, miscarriages and presence of antiphospholipid antibodies (Abs)) emphasized that ...