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In silico modeling of in situ fluidized bed melt granulation
(Elsevier Science BV, Amsterdam, 2014)
Fluidized bed melt granulation has recently been recognized as a promising technique with numerous advantages over conventional granulation techniques. The aim of this study was to evaluate the possibility of using response ...
Biocompatible microemulsions of a model NSAID for skin delivery: A decisive role of surfactants in skin penetration/irritation profiles and pharmacokinetic performance
(Elsevier Science BV, Amsterdam, 2015)
To elaborate the decisive role of surfactants in promotion of aceclofenac' skin absorption, potentially avoiding irritation, we developed non-ionic microemulsions varying natural or synthetic surfactants: sucrose esters ...
From smart materials to advanced drug delivery systems Preface
(Elsevier Science BV, Amsterdam, 2017)
An investigation into the effect of formulation variables and process parameters on characteristics of granules obtained by in situ fluidized hot melt granulation
(Elsevier Science BV, Amsterdam, 2012)
The aim of this study was to investigate the influence of binder content, binder particle size, granulation time and inlet air flow rate on granule size and size distribution, granule shape and flowability, as well as on ...
Optimization of matrix tablets controlled drug release using Elman dynamic neural networks and decision trees
(Elsevier Science BV, Amsterdam, 2012)
The main objective of the study was to develop artificial intelligence methods for optimization of drug release from matrix tablets regardless of the matrix type. Static and dynamic artificial neural networks of the same ...
Parenteral nanoemulsions of risperidone for enhanced brain delivery in acute psychosis: Physicochemical and in vivo performances
(Elsevier Science BV, Amsterdam, 2017)
This work aimed to deepen the lately acquired knowledge about parenteral nanoemulsions as carriers for brain delivery of risperidone, a poorly water-soluble antipsychotic drug, through establishing the prospective relationship ...
Solubility enhancement of desloratadine by solid dispersion in poloxamers
(Elsevier Science BV, Amsterdam, 2012)
The present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of the poorly water soluble drug substance desloratadine that can be used for the preparation of immediate ...
Critical quality attributes, in vitro release and correlated in vitro skin permeation-in vivo tape stripping collective data for demonstrating therapeutic (non) equivalence of topical semisolids: A case study of "ready-to-use" vehicles
(Elsevier Science BV, Amsterdam, 2017)
This work aimed to prove the ability of "ready-to-use" topical vehicles based on alkyl polyglucoside-mixed emulsifier (with/without co-solvent modifications) to replace the conventionally used pharmacopoeial bases (e.g., ...
Development of semisolid self-microemulsifying drug delivery systems (SMEDDSs) filled in hard capsules for oral delivery of aciclovir
(Elsevier Science BV, Amsterdam, 2017)
The study aimed to develop semisolid self-microemulsifying drug delivery systems (SMEDDSs) as carriers for oral delivery of aciclovir in hard hydroxypropylmethyl cellulose (HPMC) capsules. Six selfdispersing systems (SD1-SD6) ...
Characterization of gelation process and drug release profile of thermosensitive liquid lecithin/poloxamer 407 based gels as carriers for percutaneous delivery of ibuprofen
(Elsevier Science BV, Amsterdam, 2015)
Suitability of liquid lecithin (i.e., solution of lecithin in soy bean oil with similar to 60% w/w of phospholipids) for formation of gels, upon addition of water solution of poloxamer 407, was investigated, and formulated ...