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Artificial neural networks in analysis of indinavir and its degradation products retention
(Elsevier Science BV, Amsterdam, 2009)
Artificial neural networks (ANN) are biologically inspired computer programs designed to simulate the way in which the human brain processes the information. In the past few years, coupling of experimental design (ED) and ...
Quantitative structure retention relationships of azole antifungal agents in reversed-phase high performance liquid chromatography
(Elsevier Science BV, Amsterdam, 2012)
Artificial neural network (ANN) is a learning system based on a computational technique which can simulate the neurological processing ability of the human brain. It was employed for building of the quantitative ...
The influence of inorganic salts with chaotropic properties on the chromatographic behavior of ropinirole and its two impurities
(Elsevier Science BV, Amsterdam, 2014)
Chaotropic agents recently gained popularity as interesting and useful mobile phase additives in liquid chromatography due to their effect on analytes retention, peak symmetry and separation efficiency. They mimic the role ...
Improved chromatographic response function in HILIC analysis: Application to mixture of antidepressants
(Elsevier Science BV, Amsterdam, 2012)
This paper presents exploration of chromatographic behavior in HILIC system by experimental design and improved chromatographic response function denoted as N-CRF*. As a model mixture six antidepressants were chosen: ...
Effects of derivatization reagents consisting of n-alkyl chloroformate/n-alcohol combinations in LC-ESI-MS/MS analysis of zwitterionic antiepileptic drugs
(Elsevier Science BV, Amsterdam, 2013)
In the current study, three antiepileptic drugs with zwitterionic properties, namely vigabatrin, pregabalin and gabapentin, were chosen as model analytes to undergo derivatization by applying various n-alkyl chloroformat ...
Profiling differences in chemical composition of brain structures using Raman spectroscopy
(Elsevier Science BV, Amsterdam, 2013)
Raman spectroscopy enables non-invasive investigation of chemical composition of biological tissues. Due to similar chemical composition, the analysis of Raman spectra of brain structures and assignment of their spectral ...
Determination of metal content in some herbal drugs - Empirical and chemometric approach
(Elsevier Science BV, Amsterdam, 2005)
The concentrations of Cu, Zn, Mn, Fe, K, Ca, Mg, Al, Ba and B in 26 herbal drugs of special importance in phytopharmacywere studied. Flame atomic absorption and emission spectrometry (FAAS, FAES), as well as inductively ...
EDXRF spectrometry determination of tungsten in tobacco plants after antiviral treatment with 12-tungstophosphoric acid and its compounds
(Elsevier Science BV, Amsterdam, 2006)
In this study, we have developed a sensitive, rapid and simple procedure for the energy dispersive X-ray fluorescence (EDXRF) spectrometry measurement of tungsten in tobacco plant parts. Only 0.1 g of dried plant material ...
Simultaneous determination of cefotaxime and desacetylcefotaxime in real urine sample using voltammetric and high-performance liquid chromatographic methods
(Elsevier Science BV, Amsterdam, 2008)
Two rapid, accurate and sensitive methods are developed and validated for the quantitative simultaneous determination of cefotaxime (CFX) and its active metabolite desacetylcefotaxime (DCFX) in urine. Based on the previous ...
Advancement in optimization tactic achieved by newly developed chromatographic response function: Application to LC separation of raloxifene and its impurities
(Elsevier Science BV, Amsterdam, 2011)
In this paper a new chromatographic response function (CRF) is designed and proposed for utilization in the optimization strategies. The function capability to represent the overall quality of a experimentally obtained ...